NUT midline carcinoma of the mediastinum showing two types of poorly differentiated tumor cells: A case report and a literature review

Retrospective analysis of nuclear protein in testis (NUT) midline carcinoma in the upper aerodigestive tract and mediastinum

“…Variable positivity of NMC tumors has been noted for markers including CD99, FLI1, CD45 RO, NSE, CD34 (50%), vimentin, and focally, p16, CD56, CD138, TTF1, S-100, CD117, and PLAP. 6,11,[15][16][17][18][19][20][21] The antibody created to diagnose NMC with IHC is a rabbit monoclonal raised against amino acids 450 to 700 of the human NUT protein. 13 The IHC staining pattern demonstrates a diffuse (>90%), speckled nuclear staining in the malignant tumor cells.…”

NUT carcinoma of the thorax: Case report and review of the literature

“…Overall survival was 6.9 months. Clinical symptoms of NC are non-specific and include dyspnea, hemoptysis, chronic coughing, nausea, pain from metastasis in bones, and chest/shoulder pain [8,11,14,16]. In all cases were tumor size was provided (n=21) NC measured more than 3 cm at initial diagnosis.…”

“…Although morphology and immunophenotype are suggestive for a squamous cell carcinoma, the prognosis is worse [11] Due to its morphological and immunohistochemical features NC diagnosis in biopsy material can be challenging. In the published literature initial diagnosis from biopsy material in 14 cases was a poorly or undifferentiated carcinoma, which points out that the well differentiated tumor cell population must not be necessarily evident in small biopsies or can be completely lacking.…”

“…Comprehensive summary of relevant clinicopathological data of thoracic NC published in the literature[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Nuclear protein in testis carcinoma of the mediastinum: a case report

“…The pathophysiology involves a rearrangement of the NUT gene on chromosome 15q14 with members of the BRD gene family ( BRD 4 and BRD 3) resulting in a BRD–NUT fusion product, which decreases histone acetylation and therefore suppresses squamous cell differentiation [4, 5]. Pathological examination may reveal positivity for cytokeratins (CKs) and p63, a squamous basal cell marker, leading to the incorrect diagnosis of squamous cell carcinoma [6]. We report a case of superior vena cava syndrome revealing a NUT carcinoma of the mediastinum.…”