Nutmeg oil: Identification and quantitation of its most active constituents as inhibitors of platelet aggregation

Janssens, J.; Laekeman, Gert; Pieters, Luc; Totté, J.; Herman, Arnold G.; Vlietinck, A. J.

doi:10.1016/0378-8741(90)90054-w

Cited by 71 publications

(32 citation statements)

References 18 publications

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“…In particular, among botanicals, some essential oils were reported to affect hemostasis in various experimental models (Janssens et al, 1990;Kumagai et al, 1994;Whitaker et al, 2000). Formulations of garlic, containing alk(en)yl thiosulfates in particular, emerged as effective compounds in inhibiting platelet aggregation in human volunteers (Rahman, 2001 Moreover, onion and origanum displayed antiplatelet properties in human plasma by inhibiting arachidonate cascade and thrombin activity, respectively (Goun et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Comparative screening of plant essential oils: Phenylpropanoid moiety as basic core for antiplatelet activity

et al. 2006

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Section: Introductionmentioning

confidence: 99%

Comparative screening of plant essential oils: Phenylpropanoid moiety as basic core for antiplatelet activity

et al. 2006

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“…The fixed oil contains myristin and myristic acid. Nutmeg yields 5–15% of volatile oil, which contains pinene, sabinene, camphene, myristicin, elemicin, isoelemicin, eugenol, isoeugenol, methoxyeugenol, safrole, dimeric phenylpropanoids, lignas and neolignas [1,13,14] and by expression it yields a product known as nutmeg butter. Eugenol the major constituent inhibits lipid peroxidation and maintains activities of enzymes like superoxide dismutase, catalase, glutathione peroxidase, glutamine transferase and glucose-6-phosphate dehydrogenase [15], and has also been reported to have vasodilatory [16] and smooth muscle relaxant property [17].…”

Section: Introductionmentioning

confidence: 99%

An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg)

Tajuddin

Ahmad

Latif

et al. 2005

BMC Complement Altern Med

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BackgroundMyristica fragrans Houtt. (nutmeg) has been mentioned in Unani medicine to be of value in the management of male sexual disorders. The present study was undertaken to evaluate the aphrodisiac effect of 50% ethanolic extract of nutmeg along with its likely adverse effects and acute toxicity using various animal models.MethodsThe suspension of the extract was administered (100, 250 and 500 mg/kg, p.o.) to different groups of male rats daily for seven days. The female rats involved in mating were made receptive by hormonal treatment. The general mating behaviour, libido and potency were studied and compared with the standard reference drug sildenafil citrate. Likely adverse effects and acute toxicity of the extract were also evaluated.ResultsOral administration of the extract at the dose of 500 mg/kg, produced significant augmentation of sexual activity in male rats. It significantly increased the Mounting Frequency, Intromission Frequency, Intromission Latency and caused significant reduction in the Mounting Latency and Post Ejaculatory Interval. It also significantly increased Mounting Frequency with penile anaesthetisation as well as Erections, Quick Flips, Long Flips and the aggregate of penile reflexes with penile stimulation. The extract was also observed to be devoid of any adverse effects and acute toxicity.ConclusionThe resultant significant and sustained increase in the sexual activity of normal male rats without any conspicuous adverse effects indicates that the 50% ethanolic extract of nutmeg possesses aphrodisiac activity, increasing both libido and potency, which might be attributed to its nervous stimulating property. The present study thus provides a scientific rationale for the traditional use of nutmeg in the management of male sexual disorders.

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“…In the recent literature, MF has been investigated for its hypolipidemic, antithrombotic, antiplatelet aggregating, antifungal, aphrodisiac, anxiogenic, anti-ulcerogenic, antitumor, and anti-inflammatory activities (Ozaki et al, 1989;Park et al, 1998;Capasso et al, 2000;Sonavane et al, 2001Sonavane et al, , 2002Morita et al, 2003;Chung et al, 2006). MF has been reported to contain 25-30% fixed oils and 5-15% volatile oils such as camphene, elemicin, eugenol, isoelemicin, isoeugenol, methoxyeugenol, pinen, sabinene, safrol, and also chemical substances such as dihydroguaiaretic acid, myristic acid, myristicin, and ligan (Forrest & Heacock, 1972;Isogai et al, 1973;Janssen et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antihyperlipidemic Effects ofMyristica fragrans. in Animal Models

Arulmozhi

Kurian

Addepalli

et al. 2007

Pharmaceutical Biology

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The effect of the hydroalcoholic extract of fruits of Myristica fragrans Houtt. (Myristicaceae) was investigated on chlorpromazine-induced glucose and triglyceride elevations in male Swiss albino mice. After 7 days of oral administration, the extract, at doses of 150 and 450 mg=kg, ameliorated the metabolic abnormalities caused by chlorpromazine as evidenced by significant reduction of glucose and triglyceride (TG) levels (maximal effect of 41% and 53% reduction of glucose and TG, respectively, at 450 mg dose, p < 0.01). The standard antidiabetic rosiglitazone at 10 mg significantly (p < 0.01) reduced the TG (63%) and glucose (40%) levels in this model, while the standard antidiabetic glimepiride has exhibited 55% and 16% reduction in TG and glucose, respectively. In rats fed a high-cholesterol diet, Myristica fragrans extract significantly reduced the elevated TG (47% reduction at 450 mg, p < 0.01) and cholesterol (66.7% reduction at 450 mg, p < 0.01), and also exhibited a reduction in hepatic TG secretion after tyloxapol administration. These data suggest that Myristica fragrans extract ameliorates hyperglycemia and abnormal lipid metabolism in animal models.

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Nutmeg oil: Identification and quantitation of its most active constituents as inhibitors of platelet aggregation

Cited by 71 publications

References 18 publications

Comparative screening of plant essential oils: Phenylpropanoid moiety as basic core for antiplatelet activity

Comparative screening of plant essential oils: Phenylpropanoid moiety as basic core for antiplatelet activity

An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg)

Antidiabetic and Antihyperlipidemic Effects ofMyristica fragrans. in Animal Models

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