Nutraceutical phycocyanin nanoformulation for efficient drug delivery of paclitaxel in human glioblastoma U87MG cell line

Agrawal, Madhunika; Yadav, Sanjeev Kumar; Agrawal, Sunil; Karmakar, Surajit

doi:10.1007/s11051-017-3972-x

Cited by 15 publications

(3 citation statements)

References 27 publications

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“…2I, and their initial weight reduction of 5-10% might be due to the loss of free and loosely bound water. 36 TGA curve of Phy showed a decreasing trend starting from 168 °C. Differently, the fabricated nanocarriers showed a relatively wide curve, and the weight loss was relatively low, suggesting that the stability of the synthesized NC-8 was enhanced compared to PCs and Phy.…”

Section: Food and Function Papermentioning

confidence: 94%

Facile synthesis of food-grade and size-controlled nanocarriers based on self-assembly of procyanidins and phycocyanin

et al. 2022

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Section: Food and Function Papermentioning

confidence: 94%

Facile synthesis of food-grade and size-controlled nanocarriers based on self-assembly of procyanidins and phycocyanin

et al. 2022

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“…In a study done by Agrawal et al phycocyanin encapsulated nanoforulation has been prepared for effective cancer chemotherapy in which researchers utilized phycocyanin as a photodynamic carrier for paclitaxel to develop a combined chemo-photo-nanotherapeutics for effective management of cancer. They prepared the nanoparticles by desolvation process and studied the developed formulation on glioblastoma U87MG cell line which revealed a potential as cytotoxic [20].…”

Section: Phycocyaninmentioning

confidence: 99%

Dig & Delve into Protein Based Nanoformulations

et al. 2020

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Past few decades have emerged as the era of nanotechnology worldwide leading to an extensive research in pharmaceutical science as well as other fields. Nanoformulations have shown a promising future in therapeutics and theronostics. Protein based nanoformulations attracting attention in research as it can be used as therapeutics as well as carrier. Carrier based protein nanoformulatios are capable of accommodating range of therapeutics such as dyes, drugs, contrast agents and inorganic nanoclusters makings its application vast. The nano size of formulation enables it to reach the desired places by some modification. This paper reviewed the various protein based nanoformulation. Human serum albumin, Bovine serum albumin, soy protein isolate, phycocyanin, casein, bromelein, collagen and sericin based nanoformulations are briefly discussed. Various limitations of these proteins can be diminished by developing it in nano form and emerged as promising candidate as carrier as well as therapeutics in drug delivery advancements.

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“…It has also been used as a sensitive and selective biosensor for Hg 2+ in the aquatic environment [ 15 ]. Recently, it has also been used in nanoformulation for effective delivery of paclitaxel in human glioma cells [ 16 ]. C-PC, being structurally similar to biliverdin, mammalian cells convert it into phycocyanorubin by enzyme biliverdin reductase.…”

Section: Introductionmentioning

confidence: 99%

Phycocyanin Extracted from Oscillatoria minima Shows Antimicrobial, Algicidal, and Antiradical Activities: In silico and In vitro Analysis

Venugopal

Thakur

Chennabasappa

et al. 2020

AIAAMC

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Background: Phycocyanin is an algae-derived protein, which binds to pigment for harvesting light. It has been reported in various different species, including that of red algae, dinoflagellates, and cryptophyta. Importantly, phycocyanin has enormous applications, including cosmetic colorant, food additive, biotechnology, diagnostics, fluorescence detection probe, an anticancer agent, anti-inflammatory, immune enhancer, etc. In addition, several different algae were utilized for the isolation of cyano-phycocyanin (C-PC), but most of the purification methods consist of several steps of crude extraction. Aim: To isolate C-PC from a new source of microalgae with better purity level and to evaluate its antimicrobial, algicidal, and antiradical activities. Methods: Biological activity, permeability, pharmacokinetics, and toxicity profile of C-PC were predicted by in silico studies. C-PC was purified and isolated by using ammonium sulphate precipitation, ion-exchange chromatography and gel-filtration chromatography. C-PC was characterized by SDS-PAGE and elution profile (purity ratio) analysis. Antimicrobial and algicial activities of C-PC were evaluated by the microtitre plate based assays. Antiradical activity of C-PC was evaluated by DPPH- and ABTS*+ radical scavenging assays. Conclusion: C-PC was extracted from Oscillatoria minima for the first time, followed by its quantitative as well qualitative evaluation, indicating a new alternative source of this important protein. Furthermore, the antimicrobial, algicidal, and antiradical activities of the isolated C-PC extract have been demonstrated by both in silico as well as in vitro methods.

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Nutraceutical phycocyanin nanoformulation for efficient drug delivery of paclitaxel in human glioblastoma U87MG cell line

Cited by 15 publications

References 27 publications

Facile synthesis of food-grade and size-controlled nanocarriers based on self-assembly of procyanidins and phycocyanin

Facile synthesis of food-grade and size-controlled nanocarriers based on self-assembly of procyanidins and phycocyanin

Dig & Delve into Protein Based Nanoformulations

Phycocyanin Extracted from Oscillatoria minima Shows Antimicrobial, Algicidal, and Antiradical Activities: In silico and In vitro Analysis

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