NutriSim© Diminishes an Endotoxin-stimulated Proinflammatory Cytokine Production

Abstract

Lipopolysaccharide, a main co mponent of Gram-negative bacterial endotoxin is the lead ing cause of sepsis or endotoxic shock. This condition generates tissue hypoperfusion and leads to a state of acute metabolic-circulatory dysfunction and multio rgan systemic failure wh ich contributes to amplify the inflammatory response and resulting in the release of pro-inflammatory cytokines (TNF-α, IL-1 and IL-6). The effect of NutriSim© on serum pro-inflammatory cytokine concentrations were investigated in lipopolysaccharide-treated male W istar rats. Animals were rando mized into five groups: control groups receiv ing a single intraperitoneal in jection of physiologic saline solution or NutriSim© (10µl), respectively; LPS (20 mg/Kg, i.p.); NutriSim© treat ment 15 min before o r after LPS in the same aforementioned dose. The results showed that a single dose of NutriSim© prio r or before the endotoxic insult diminishes significantly the production of serum TNF-α, IL-1 and IL-6. Therefore NutriSim© can modulate an inflammatory response in experimental model of endotoxic shock.