Two field experiments were carried out at Wadi El-Noran Farm, Al-Abtal Village, Eastern Suez Canal, Ismailia Governorate (latitude of 30 0 18 N and longitude of 32 0 30 E) in 2013/2014 and 2014/2015 seasons to evaluate the performance of two mono-germ sugar beet varieties namely Nancy and Karim (Beta vulgaris var. saccharifera L.), as affected by the applications of boron, potassium and calcium fertilization whither as single element application or as a mixture of the three elements on growth, yield and quality of sugar beet under sandy soil settings. The treatments were arranged in split plots design with four replicates where varieties were arranged in main plots and the mineral spray applications were arranged in sub-plots. The present work included ten treatments represent the interactions between the two sugar beet varieties and five combinations of three elements including the following: 1. without application of elements (control), 2. Application of 150 ppm boron/fed (as boric acid 17% boron), 3. Application of 2 L potassium/fed (as potassien-P compound including 30% K 2 O + 8% P 2 O 5 /l), 4. Application of one liter of calcium/fed as form of compound Calso-x (8% chelated calcium as calcium carbamide, claw on humic acid 10% and free amino acid 3%), 5. Application of the combination of (potassium + boron + calcium) at the previously mentioned levels. The fertilization treatments were given as foliar application/400 liter water/fed, Results indicated that Karim variety had the highest values in Leaf area index, root and foliage fresh weighs (g/plant), total dry weight (g/plant), as well as root and extracted sugar yields(t/fed). Meantime, Nancy had surpassed Karim in sucrose%, extracted sugar% and quality index%.Foliar application of sole and combined applications of the three elements was significantly affected in leaf area index, root and foliage fresh weighs g/plant, and total dray weight g/plant compared to untreated. Fertilizing sugar beet by mixture of potassium +Boron + Calcium recorded a important increase in root and extracted sugar yields/fed and sucrose% as compared to untreated. Karim variety achieved the highest value of extracted sugar yield/fed when treated by mixture application of (B, K and Ca) while, untreated Nancy variety gave the lowest value. It could be recommend that fertilizing Karim variety by mixture of 150 ppm B+ 2 L potassien-P + one L Ca/400 L water/fed as foliar application to get the maximum of root and sugar yields/fed under this experimental conditions.