Nutritional aspects in patient undergoing liver resection

Ciuni, Roberto; Biondi, Antonio; Grosso, Giuseppe; Nunnari, Giuseppe; Panascia, E; Randisi, L.; Volpes, Riccardo; Arcadipane, Antonio; Burzotta, Francesco; Gridelli, Bruno; Gruttadauria, Salvatore

doi:10.1007/s13304-011-0121-4

Cited by 23 publications

(22 citation statements)

References 32 publications

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“…The CgA levels in the Barcelona staging of HCC was higher in stage D compared to stage C (p<0.01), to stage B (p<0.001), and to stage A (p<0.001). The most frequent site of neuroendocrine tumours is the gastrointestinal tract, accounting for approximately 70% [15] of the total neuroendocrine tumours in the body [16,17]. Neuroendocrine tumours frequently metastasize to the liver, but the liver itself seldom is the site of a primary tumour [18-20].…”

Section: Resultsmentioning

confidence: 99%

Elevated serum levels of Chromogranin A in hepatocellular carcinoma

et al. 2012

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BackgroundDuring the past three decades, the incidence of hepatocellular carcinoma in the United States has tripled. The neuroendocrine character has been observed in some tumor cells within some hepatocellular carcinoma nodules and elevated serum chromogranin A also been reported in patients with hepatocellular carcinoma. The aim of this work was to investigate the role of serum concentration of chromogranin A in patients with hepatocellular carcinoma at different stages.MethodsThe study population consisted of 96 patients (63 males and 33 females age range 52-84) at their first hospital admission for hepatocellular carcinoma. The control group consisted of 35 volunteers (20 males and 15 females age range 50-80). The hepatocellular carcinoma patients were stratified according the Barcelona-Clinic Liver Cancer classification. Venous blood samples were collected before treatment from each patients before surgery, centrifuged to obtain serum samples and stored at -80° C until assayed.ResultsThe chromogranin A serum levels were elevated (> 100 ng/ml) in 72/96 patients with hepatocellular carcinoma. The serum levels of chromogranin A were significantly correlated (p<0.05) with alpha-fetoprotein. In comparison with controls, the hepatocellular carcinoma patients showed a significant increase (p<0.001) vs controls. The chromogranin A levels in the Barcelona staging of hepatocellular carcinoma was higher in stage D compared to stage C (p<0.01), to stage B (p<0.001), and to stage A (p<0.001).ConclusionsMolecular markers, such as chromogranin A, could be very useful tools for hepatocellular carcinoma diagnosis. However the molecular classification should be incorporated into a staging scheme, which effectively separated patients into groups with homogeneous prognosis and response to treatment, and thus serves to aid in the selection of appropriate therapy.

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Section: Resultsmentioning

confidence: 99%

Elevated serum levels of Chromogranin A in hepatocellular carcinoma

et al. 2012

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“…Глюконеогенез, происходящий в печени, потребляет до 40-60% лактата. В случае повреждения печени, она вырабатывает лактат, а не метаболизирует его [103].…”

Section: оригинальные исследованияunclassified

Modern aspects of correction of disturbances arising from extended hemihepatectomy in children

Белоусова¹,

Сотников²,

Matinyan³

2018

Anesteziologiya I Reanimatologiya

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В последнее время в мире участились случаи выявления опухолевых образований печени. Наиболее распространенной опухолью печени у детей является гепатобластома (ГБЛ). Она выявляется чаще всего в течение первых 3 лет жизни. Заболеваемость составляет около 10,5 случая на 1 млн детей в возрасте до 1 года и 5,2 случая на 1 млн в возрасте от 1 до 4 лет, согласно данным SEER [1]. С 1992 по 2004 г. заболеваемость ГБЛ в США выросла на 4% [2], а в Европе в период с 1978 по 1997 г.-на 1%. ГБЛ часто ассоциируется с низкой массой тела при рождении, синдромом семейного аденоматозного полипоза, синдромом Беквит или генетическими аномалиями [3], такими как трисомия по 18-й хромосоме и синдром Беквит-Видеманна [4]. К негативным прогностическим факторам долгосрочной выживаемости при ГБЛ относятся наличие метастати

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“…In fact, there is relatively weak evidence to support the practice of carbohydrate loading in advance of surgery, but afterward it is clear that early introduction of enteral nutrition can reduce overall morbidity and specifically septic complications (39)(40)(41)(42). Following hepatic resections, patients are in a catabolic state characterized by glucose and electrolyte imbalances mitigated by increased metabolic demand (43). Some surgeons advocate the use of glucose containing fluids in the post-resection resuscitation algorithms in order to abrogate the catabolism.…”

Section: Nutritionmentioning

confidence: 99%