Nutritional composition, phytochemical extraction, and pharmacological potential of mulberry: A comprehensive review

Kattil, Adarsh; Hamid,; Dash, Kshirod Kumar; Shams, Rafeeya; Sharma, Shakshi

doi:10.1016/j.fufo.2024.100295

Cited by 9 publications

(2 citation statements)

References 83 publications

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“…10 M. alba is a native Chinese tree widely cultivated all over the world, and it has been utilized by local residents as both food and natural remedy for a very long history. 11 Almost all parts of this species, comprising fruits, leaves, twigs, and root bark, are collected in the National Pharmacopoeia of China for treating a variety of disorders. 12 In the present project, we have carried out an intensive chemical investigation into the ethanol extract of the root bark of M. alba, known as Sang-Bai-Pi in traditional Chinese medicine, leading to the isolation and identification of a panel of stilbenoid Diels−Alder adducts (1−15, Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…M. alba is a native Chinese tree widely cultivated all over the world, and it has been utilized by local residents as both food and natural remedy for a very long history . Almost all parts of this species, comprising fruits, leaves, twigs, and root bark, are collected in the National Pharmacopoeia of China for treating a variety of disorders .…”

Section: Introductionmentioning

confidence: 99%

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Structurally Diverse Stilbenoids as Potent α-Glucosidase Inhibitors with Antidiabetic Effect from Morus alba

Tian,

Bi,

Zhang

2024

J. Agric. Food Chem.

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Fifteen stilbenoid derivatives, including five previously undescribed ones (albaphenols A−E, 1−5) with diverse scaffolds, were obtained from the well-known agricultural economic tree Morus alba. Their structures, including absolute stereochemistries, were fully characterized by detailed interpretation of spectroscopic data and quantum chemical computational analyses of nuclear magnetic resonance (NMR) and electric circular dichroism (ECD). Albaphenol A (1) features an unprecedented rearranged carbon skeleton incorporating a novel 2-oxaspiro[bicyclo[3.2.1]octane-6,3′-furan] motif; albaphenol C (3) is likely derived from a cometabolite through an interesting intramolecular transesterification reaction; and albaphenol E (5) bears a cleavage-reconnection scaffold via a dioxane ring. All of the compounds exhibited significant inhibition against the diabetic target αglucosidase, with low to submicromole IC 50 values (0.70−8.27 μM), and the binding modes of selected molecules with the enzyme were further investigated by fluorescence quenching, kinetics, and molecular docking experiments. The antidiabetic effect of the most active and abundant mulberrofuran G (6) was further assessed in vivo in diabetic mice, revealing potent antihyperglycemic activity and comparable antidiabetic efficacy to the clinical drug acarbose.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structurally Diverse Stilbenoids as Potent α-Glucosidase Inhibitors with Antidiabetic Effect from Morus alba

Tian,

Bi,

Zhang

2024

J. Agric. Food Chem.

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Prenylated Flavanone Enantiomers with α‐Glucosidase Inhibitory Activity from the Root Bark of Morus alba

Bi,

Tian,

Bao

et al. 2024

Chemistry & Biodiversity

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A focused chemical investigation into the polar fractions of a well‐known traditional Chinese medicine called Sang‐Bai‐Pi (the root bark of Morus alba) yielded a panel of prenylated flavanones. The new compounds were identified as four pairs of enantiomers (1a/1b‐4a/4b) featuring the same constitution structure, on the basis of HRMS, NMR and ECD analyses. Several previously reported known racemic co‐metabolites were also analyzed and separated by HPLC on chiral columns, and the absolute configurations of pure enantiomers were established via ECD technique for the first time. The inhibition of these isolates against the antidiabetic target a‐glycosidase was further tested, with most of them showing decent inhibitory activity compared with the positive control acarbose. The interaction mechanism of two selected compounds (3a & 4b) was explored by kinetics experiment, which revealed a mixed type of inhibition pattern toward the enzyme.

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Influence of mulberry, pectin, rutin, and their combinations on α-amylase activity and glucose absorption during starch digestion

Jiang,

Gao,

Ming

et al. 2025

Food Chemistry

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Nutritional composition, phytochemical extraction, and pharmacological potential of mulberry: A comprehensive review

Cited by 9 publications

References 83 publications

Structurally Diverse Stilbenoids as Potent α-Glucosidase Inhibitors with Antidiabetic Effect from Morus alba

Structurally Diverse Stilbenoids as Potent α-Glucosidase Inhibitors with Antidiabetic Effect from Morus alba

Prenylated Flavanone Enantiomers with α‐Glucosidase Inhibitory Activity from the Root Bark of Morus alba

Influence of mulberry, pectin, rutin, and their combinations on α-amylase activity and glucose absorption during starch digestion

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