Nutritional deficiencies distribution in asymptomatic patients with pancreatic exocrine insufficiency due to chronic pancreatitis

Kovacheva-Slavova, Mila; Siminkovitch, Sylvie; Genov, Jordan; Golemanov, Branimir; Mitova, R; Gecov, Plamen; Vladimirov, Borislav

doi:10.1016/j.pan.2018.05.296

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mixed triglyceride breath test (¹³C-MTG-breath test) evaluates PEI with a sensitivity of over 90%, could diagnose mild and moderate PEI and can be used to monitor the effect of pancreatic enzyme replacement therapy (PERT). Secretin-enhanced MRCP (figure 3) has been already briefly reviewed (20). Patients with mild and moderate PEI are also at risk for developing nutritional deficiencies small meals with normal fat intake), fat-soluble vitamins and systemic follow-up, including BMI and nutrition parameters (prealbumin, RBP, fat-soluble vitamins, trace elements).…”

Section: Figurementioning

confidence: 99%

Pancreatic cancer as a complication of chronic pancreatitis – diagnostic approach

Getsov

2019

ijmsci

View full text Add to dashboard Cite

Patients with underlying chronic pancreatitis (CP) are at increased risk of pancreatic cancer (PC) development. The pathogenesis of the neoplastic transformation remains unclear. However, chronic inflammation, pancreatic stellate cells over-proliferation and genetic alterations play a major role in carcinogenesis progression. Early diagnosis and differentiation between benign and malignant disease is of a great importance. Better understanding the connection of the two entities could provide new therapeutic options.

show abstract

Section: Figurementioning

confidence: 99%

Pancreatic cancer as a complication of chronic pancreatitis – diagnostic approach

Getsov

2019

ijmsci

View full text Add to dashboard Cite

show abstract

Up-To-Date View on the Clinical Manifestations and Complications of Chronic Pancreatitis

Kovacheva-Slavova¹,

Getsov²,

Vladimirov³

et al. 2019

Pancreatitis

View full text Add to dashboard Cite

Chronic pancreatitis is an inflammatory disease that causes irreversible anatomical changes including infiltration of inflammatory cells, fibrosis and pancreatic calcification with destruction of the structure of the gland, leading to abdominal pain, endocrine and exocrine dysfunction. Pancreatic exocrine insufficiency (PEI) prevalence in chronic pancreatitis varies between 40 and 94%. PEI is diagnosed by direct and indirect tests. Nutritional status is assessed by anthropometric indicators; laboratory tests-hemoglobin, plasma proteins (albumin, prealbumin, retinol-binding protein, transferrin), fat-soluble vitamins A, D, E, K; micronutrients. Pancreatic enzyme replacement therapy (PERT) is a fundamental part of PEI treatment. An optimal PERT could prevent serious PEI complications such as metabolic bone disease, adverse cardiovascular events, cachexia, poor quality of life and mortality. A periodic screening for PEI complications with a respect to their primary and secondary prophylaxis is mandatory. Diabetes mellitus secondary to pancreatic disease is defined as pancreatogenic diabetes or type 3c diabetes mellitus. Patients with chronic pancreatitis are at increased risk for pancreatic cancer influenced by smoking, alcohol abuse, chronic inflammation and pancreatic stellate cells over-proliferation. However, chronic pancreatitis could be further complicated with splenic vein thrombosis, pseudocysts, duodenal or biliary obstruction, pseudoaneurysm and pancreatic duct stones which might require endoscopic or surgical treatment.

show abstract

Nutritional deficiencies distribution in asymptomatic patients with pancreatic exocrine insufficiency due to chronic pancreatitis

Cited by 2 publications

References 0 publications

Pancreatic cancer as a complication of chronic pancreatitis – diagnostic approach

Pancreatic cancer as a complication of chronic pancreatitis – diagnostic approach

Up-To-Date View on the Clinical Manifestations and Complications of Chronic Pancreatitis

Contact Info

Product

Resources

About