Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents

Moreno, Fernando Salvador; Heidor, Renato; Pogribny, Igor P.

doi:10.1080/01635581.2016.1180410

Cited by 23 publications

(12 citation statements)

References 190 publications

(154 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been demonstrated that curcumin can reduce the occurrence and/or delay the development of HCC by epigenetic mechanisms such as DNA demethylation and histone deacetylases (HDAC)-inhibitory effect [ 126 ]. Furthermore, Curcumin can modulate miRs in liver diseases [ 127 ].…”

Section: Cellular and Molecular Mechanisms Of Curcumin In The Prevmentioning

confidence: 99%

Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective

et al. 2018

View full text Add to dashboard Cite

Oxidative stress has been considered a key causing factor of liver damage induced by a variety of agents, including alcohol, drugs, viral infections, environmental pollutants and dietary components, which in turn results in progression of liver injury, non-alcoholic steatohepatitis, non-alcoholic liver disease, liver fibrosis and cirrhosis. During the past 30 years and even after the major progress in the liver disease management, millions of people worldwide still suffer from an acute or chronic liver condition. Curcumin is one of the most commonly used indigenous molecules endowed by various shielding functionalities that protects the liver. The aim of the present study is to comprehensively review pharmacological effects and molecular mechanisms, as well as clinical evidence, of curcumin as a lead compound in the prevention and treatment of oxidative associated liver diseases. For this purpose, electronic databases including “Scopus,” “PubMed,” “Science Direct” and “Cochrane library” were extensively searched with the keywords “curcumin or curcuminoids” and “hepatoprotective or hepatotoxicity or liver” along with “oxidative or oxidant.” Results showed that curcumin exerts remarkable protective and therapeutic effects of oxidative associated liver diseases through various cellular and molecular mechanisms. Those mechanisms include suppressing the proinflammatory cytokines, lipid perodixation products, PI3K/Akt and hepatic stellate cells activation, as well as ameliorating cellular responses to oxidative stress such as the expression of Nrf2, SOD, CAT, GSH, GPx and GR. Taking together, curcumin itself acts as a free radical scavenger over the activity of different kinds of ROS via its phenolic, β-diketone and methoxy group. Further clinical studies are still needed in order to recognize the structure-activity relationships and molecular mechanisms of curcumin in oxidative associated liver diseases.

show abstract

Section: Cellular and Molecular Mechanisms Of Curcumin In The Prevmentioning

confidence: 99%

Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective

et al. 2018

View full text Add to dashboard Cite

show abstract

“…It showed anti-cancer effect on skin-, blood-, colon-, breast-, prostate-, pancreatic and other cancers 10 , 11 . In the case of HCC, SFN has shown chemopreventive 12 – 14 and chemotherapeutic effects. It was found to decrease cell viability, telomerase activity 15 , and to induce apoptosis in hepatocellular carcinoma cells 16 , 17 as well as in an orthotopic xenograft tumor model of HCC 18 .…”

Section: Introductionmentioning

confidence: 99%

Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling

Liu

Atkinson

Akbareian

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of which is explored for cancer prevention and treatment. The dietary phytochemical sulforaphane (SFN) is known for its anti-cancer properties in vitro and in vivo; but until now, no study has focused on the role of SFN in HCC tumor angiogenesis. In the present study, in vitro cell models using a HCC cell line, HepG2, and human endothelial cells, HUVECs, as well as ex vivo and in vivo models have been used to investigate the anti-tumor and anti-angiogenic effect of SFN. The results showed that SFN decreased HUVEC cell viability, migration and tube formation, all of which are important steps in angiogenesis. More importantly, SFN markedly supressed HepG2-stimulated HUVEC migration, adhesion and tube formation; which may be due to its inhibition on STAT3/HIF-1α/VEGF signalling in HepG2 cells. In addition, SFN significantly reduced HepG2 tumor growth in a modified chick embryo chorioallantoic membrane (CAM) assay, associated with a decrease of HIF-1α and VEGF expression within tumors. Collectively, these findings provide new insights into the inhibitory effect of SFN on HCC tumor angiogenesis as well as tumor growth, and indicate that SFN has potential for the prevention and treatment of HCC.

show abstract

“…Several anticancer drugs, such as vinblastine, teniposide, camptothecin, docetaxel, etoposide, and paclitaxel, have been either identified in natural sources or synthesized by modification of molecules having natural origins [6,7]. Numerous natural products, including phytochemicals of dietary and non-dietary origin, have been shown to modulate various signaling pathways linked to hepatocarcinogenesis in vitro and in vivo, which could be valuable for the prevention and treatment of HCC [8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Based on the analysis of the available literature presented here, polyphenols could be considered as potent autophagy modulators for HCC therapy. Although numerous in vitro and in vivo studies have reported the beneficial roles of polyphenols in treating HCC [8][9][10][11][12][13][14][15][16], there are hardly any clinical trials to realize the full potential of preclinical studies. For this purpose, it is worthwhile to explore polyphenols alone or in combination with approved drugs for the treatment of human HCC.…”

Section: Introductionmentioning

confidence: 99%

Autophagy: A Potential Therapeutic Target of Polyphenols in Hepatocellular Carcinoma

Kiruthiga

Devi

Nabavi

et al. 2020

Cancers

View full text Add to dashboard Cite

Autophagy is a conserved biological phenomenon that maintains cellular homeostasis through the clearing of damaged cellular components under cellular stress and offers the cell building blocks for cellular survival. Aberrations in autophagy subsidize to various human pathologies, such as dementia, cardiovascular diseases, leishmaniosis, influenza, hepatic diseases, and cancer, including hepatocellular carcinoma (HCC). HCC is the fifth common mortal type of liver cancer globally, with an inhomogeneous topographical distribution and highest incidence tripled in men than women. Existing treatment procedures with liver cancer patients result in variable success rates and poor prognosis due to their drug resistance and toxicity. One of the pathophysiological mechanisms that are targeted during the development of anti-liver cancer drugs is autophagy. Generally, overactivated autophagy may lead to a non-apoptotic form of programmed cell death (PCD) or autophagic cell death or type II PCD. Emerging evidence suggests that manipulation of autophagy could induce type II PCD in cancer cells, acting as a potential tumor suppressor. Hence, altering autophagic signaling offers new hope for the development of novel drugs for the therapy of resistant cancer cells. Natural polyphenolic compounds, including flavonoids and non-flavonoids, execute their anticarcinogenic mechanism through upregulating tumor suppressors and autophagy by modulating canonical (Beclin-1-dependent) and non-canonical (Beclin-1-independent) signaling pathways. Additionally, there is evidence signifying that plant polyphenols target angiogenesis and metastasis in HCC via interference with multiple intracellular signals and decrease the risk against HCC. The current review offers a comprehensive understanding of how natural polyphenolic compounds exhibit their anti-HCC effects through regulation of autophagy, the non-apoptotic mode of cell death.

show abstract

Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents

Cited by 23 publications

References 190 publications

Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective

Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective

Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling

Autophagy: A Potential Therapeutic Target of Polyphenols in Hepatocellular Carcinoma

Contact Info

Product

Resources

About