Nutritional Intervention and Its Impact on the Inflammatory Process in Women with Polycystic Ovarian Syndrome

Abstract

Introduction: We aimed to investigate the impact of a diet in the inflammatory profile of overweight and/or obese women diagnosed with Polycystic Ovary Syndrome (PCOS). Methods: A study was conducted in Natal, Brazil selecting overweight/obese (BMI ≥25 and <39 kg/m 2) women (18-35 years old).). The inflammatory markers were dosed by chemiluminescence without immulitis equipment. Dietary recall questionnaires, repeated 24h. were collected at baseline and after twelve weeks of the intervention. Results: The Anthropometric indicators and clinical signs of Polycystic Ovarian Syndrome showed that women with PCOS 45% (n= 10) were overweight and 54.6% (n= 12) were obese. Regarding cardiovascular risk, 86.4% presented a risk of metabolic disorders and consequently an increase in cardiovascular disease After a 12-week intervention there was the improvement in the lipid profile weight, anthropometric, hormonal, and biochemical parameters. The Weight decreased 3.5% (~2 kg) was associated with significant reduction in BMI (28.9 ± 5.2 Kg/m 2), FSH (2.4 ± 0.9 mUI/mL), testosterone (129 ± 41 ng/dL), SHBG (115 ± 81.4 mmol/L) and a levels and ease in progesterone (1.89 ± 0.76). It was also noted a reduction of plasma insulin (5.5 ± 1.4 µUI/mL), HOMA-IR 0.9 ± 0.3 mol x µUI), QUICK (0.38 ± 0.02 and LDL-cholesterol levels (86 ± 0.01 mg/dL) as shown in table 4. The Profile of Inflammatory markers in the table 5 in women with polycystic ovarian syndrome. showed a decrease in hs-PCR (39.7 ± 7mg/L), TNF-α (5.3 ± 1.1 pg/mL) and IL-6 (2.3 ± 0.2 pg/mL). Conclusion: Inflammatory cytokines and inflammation indicators levels decreased after intervention in women with PCOS indicating the relevance of a nutritional approach in this group of patients.