Nutritional Interventions in Children with Brain Injuries: A Systematic Review

Colonetti, Tamy; Uggioni, Maria Laura Rodrigues; Ferraz, Sarah Dagostin; Rocha, Marina Campos; Cruz, Mateus; Rosa, Maria Inês da; Grande, Antônio José

doi:10.3390/nu13041130

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…These cognitive, sensory, behavioral, emotional, and physical disturbances following mTBI affect functioning of the brain and may lead to long-term impairments if not treated and managed correctly (3,6,(9)(10)(11)(12)(13). It may take time for injury symptoms to manifest, and severity will vary.…”

Section: Introductionmentioning

confidence: 99%

Nutritional interventions to support acute mTBI recovery

et al. 2022

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When mild traumatic brain injury (mTBI) occurs following an impact on the head or body, the brain is disrupted leading to a series of metabolic events that may alter the brain's ability to function and repair itself. These changes may place increased nutritional demands on the body. Little is known on whether nutritional interventions are safe for patients to implement post mTBI and whether they may improve recovery outcomes. To address this knowledge gap, we conducted a systematic review to determine what nutritional interventions have been prescribed to humans diagnosed with mTBI during its acute period (<14 days) to support, facilitate, and result in measured recovery outcomes.MethodsDatabases CINAHL, PubMed, SPORTDiscus, Web of Science, and the Cochrane Library were searched from inception until January 6, 2021; 4,848 studies were identified. After removing duplicates and applying the inclusion and exclusion criteria, this systematic review included 11 full papers.ResultsPatients that consumed enough food to meet calorie and macronutrient (protein) needs specific to their injury severity and sex within 96 h post mTBI had a reduced length of stay in hospital. In addition, patients receiving nutrients and non-nutrient support within 24–96 h post mTBI had positive recovery outcomes. These interventions included omega-3 fatty acids (DHA and EPA), vitamin D, mineral magnesium oxide, amino acid derivative N-acetyl cysteine, hyperosmolar sodium lactate, and nootropic cerebrolysin demonstrated positive recovery outcomes, such as symptom resolution, improved cognitive function, and replenished nutrient deficiencies (vitamin D) for patients post mTBI.ConclusionOur findings suggest that nutrition plays a positive role during acute mTBI recovery. Following mTBI, patient needs are unique, and this review presents the potential for certain nutritional therapies to support the brain in recovery, specifically omega-3 fatty acids. However, due to the heterogenicity nature of the studies available at present, it is not possible to make definitive recommendations.Systematic review registrationThe systematic review conducted following the PRISMA guidelines protocol was registered (CRD42021226819), on Prospero.

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Section: Introductionmentioning

confidence: 99%

Nutritional interventions to support acute mTBI recovery

et al. 2022

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Section: Introductionmentioning

confidence: 99%

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Nutrition Management in Pediatric Traumatic Brain Injury: An Exploration of Knowledge Gaps and Challenges

Chowdhury,

Sahu,

Bindra

2024

J Neuroanaesth Crit Care

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Traumatic brain injury (TBI) stands as the leading cause of morbidity and mortality among children, as evidenced by the most contemporary statistics. Undernutrition in pediatric TBI (PTBI) leads to increased mortality, heightened infectious complications, and more severe neurological consequences. Therefore, timely and effective nutritional therapy is crucial in managing PTBI to improve patient prognosis and outcomes. Limited investigations have been conducted on the nutritional requirements specific to these patients and management often relies on data from adults with TBI for guidance. We have meticulously searched different databases to compile a broad range of the most up-to-date clinical research. This review analyses the challenges associated with providing nutritional support to children with TBI and provides a clearer understanding of the current evidence-based recommendations for optimal nutritional therapy. The review primarily focuses on recommendations and suggestions for energy requirements, nutritional assessment, initiation of nutrition, various feeding methods offered, identification of malnutrition, the impact of malnutrition on patient outcomes, and areas of further research.

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Nutritional Interventions in Children with Brain Injuries: A Systematic Review

Cited by 4 publications

References 24 publications

Nutritional interventions to support acute mTBI recovery

Nutritional interventions to support acute mTBI recovery

Data_Sheet_2.docx

Nutrition Management in Pediatric Traumatic Brain Injury: An Exploration of Knowledge Gaps and Challenges

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