Nutritional Status and Depression, Sleep Disorder, and Quality of Life in Hemodialysis Patients

Bilgic, Ayse; Akgul, A.; Sezer, Sıren; Arat, Z.; Özdemir, Fatma Nurhan; Haberal, Mehmet

doi:10.1053/j.jrn.2007.08.008

Cited by 73 publications

(65 citation statements)

References 33 publications

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“…A negative correlation was found between albumin level and brief arousal index and PLM in all the studied groups (r ¼ À0.6607, p50.0001 and r ¼ À0.581, p50.0001), respectively. These results were in agreement with the results of other investigators 12,13 who found that hypoalbuminemia reported to be associated with disturbed sleep insomnia and RLS. In our study there was positive correlation between Hb level and sleep efficiency and total sleep time in all the studied groups (r ¼ 0.371, p ¼ 0.0003 and r ¼ 0.531, p50.0001) respectively, but a negative correlation was found between Hb level and brief arousal index and PLM (r ¼ À0.543, p50.0001 and r ¼ À0.5087, p50.0001), respectively.…”

Section: Discussionsupporting

confidence: 94%

Prevalence of sleep disorders among ESRD patients

Ezzat

Mohab

2015

Renal Failure

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Sleep disorders are common among the patients undergoing dialysis in end stage renal disease (ESRD). Although variable, their prevalence has been reported to be higher when compared to the general population. The most frequently reported complaints are insomnia, restless leg syndrome (RLS), sleep-disordered breathing and excessive daytime sleepiness (EDS). The aim of this study was to assess the prevalence of sleep disorders in end stage renal disease patients on regular hemodialysis (group I with 30 patients) and CKD patients (group II with 30 patients) in comparison to 30 normal population (control group). In addition to laboratory investigations which included creatinine clearance using Cockroft and Gault formula, hemoglobin level (Hb), blood urea, serum creatinine, serum albumin, serum calcium and phosphorus and lipid profile, all subjects underwent one night of laboratory-based polysomnography (PSG) consisting of a standard montage of electroencephalography (EEG) (C3/A1 and O2/C3 or O1/C4), monopolar left and right electrooculography (EOG) referenced to the opposite mastoid, surface mentalis electromyography (EMG), respiratory airflow (measured by thermistor) and effort (piezoelectric sensors), electrocardiography (ECG), anterior tibialis EMG and pulse oximetry. For hemodialysis subjects, this study was performed on a night immediately following hemodialysis treatment. The results showed that patients on hemodialysis have sleep disorders, and that sleep disorders are common in group I and II than control group. The percentage of sleep disorders in hemodialysis patients were as follows: insomnia (69%), followed by obstructive sleep apnea syndrome OSAS (24%), RLS and periodic limb movement PLM (18%), nightmares (13%), EDS (12%), sleepwalking (2%), possible rapid eye movement behavior disorders RED (2%), possible narcolepsy (1.4%). While the percentage of sleep disorders in CKD patients were as follows: insomnia (54%), followed by RLS (19%), PLM (12%), OSAS (16%), nightmares (15%), EDS (15%), sleepwalking (4%), possible RBD (3%), possible narcolepsy (1%). There was inverse correlation between sleep disorders and Hb, albumin and creatinine clearance; also there was positive correlation between sleep disorder and phosphorus. We concluded that the sleep disorders are common in CKD patients either on conservative management or on regular hemodialysis. Treatment of anemia, hyperphosphatemia and hypoalbuminemia may improve sleep disorders among those patients.

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Section: Discussionsupporting

confidence: 94%

Prevalence of sleep disorders among ESRD patients

Ezzat

Mohab

2015

Renal Failure

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“…45 Likewise we also found significant positive correlation of protein energy wasting with Beck Depression Inventory scores. However, protein intake was positively associated with perceived stress in our study.…”

Section: Discussionsupporting

confidence: 67%

The role of adipocytokines on depressive symptoms of patients with chronic kidney disease

Kaynar

Özkorumak²,

Kural³

et al. 2013

Renal Failure

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“…Depending on these findings we think that depression and poor sleep quality are closely associated with inflammatory conditions and malnutrition. In fact, in previous studies it was reported that higher malnutrition-inflammation scores were associated with the presence of moderate-to-severe depression and poor sleep and life quality in hemodialysis patients (26) patients who are good sleepers (21,22). We did not find such a relationship between sleep quality and hemoglobin, PTH, calcium, or phosphorus values.…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Necontrasting

confidence: 75%

Association of Nutritional Status with Depression and Sleep Disorders in Elderly End Stage Renal Disease Patients - Does Chronic Inflammation Cause it all?

Bilgic¹,

Ibis²,

Tutal³

et al. 2012

Turk Neph Dial Transpl

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OBjEcTIvE: In our study we aimed to analyze the association between nutritional status and depression and sleep disturbance in elderly dialysis patients. mATErIAl and mEThOdS: Seventy-three patients receiving dialysis treatment older than 65 years of age were enrolled in this study. Nutritional status was determined by Subjective Global Assessment (SGA). Patients were also evaluated with Beck Depression Inventory and Pittsburg Sleep Quality Index. Demographic and laboratory data were recorded.rESulTS: According to SGA, 48 (65.8%) patients were well nourished and 25 (34.2%) patients had mild-moderate and severe malnutrition. When the well-nourished and malnourished patients were compared, the well-nourished group had higher albumin (p<.0001) and creatinine (p=.03) levels, higher body mass indices (p<.01), lower CRP levels (p<.0001), better quality of sleep (p<.0001) and lower depression scores (p<.0001) than the malnourished group. When we grouped patients as Group I (not depressive and good sleep quality), Group II (depressive but good sleep quality) and Group III (both depressive and poor sleep quality, we found that Group III had the lowest albumin (p < .0001) and highest CRP (p < .0001) values when compared to the other two groups.cOncluSIOn: Depression, sleep disorders, and the nutritional status are important factors which interact with each other and elderly dialysis patients with malnutrition should be well assessed for the presence of any inflammatory status and/or psychological-sleep disorders.KEy wOrdS: Elderly patients, Dialysis, Malnutrition, Depression, Sleep disorder Öz AmAç: Çalışmamızda yaşlı diyaliz hastalarında beslenme durumu ile depresyon ve uyku bozukluğu arasındaki ilişkiyi incelemeyi amaçladık. gErEç ve yÖnTEmlEr: Çalışmaya diyaliz tedavisi almakta olan 65 yaş üzerindeki 73 hasta alındı. Beslenme durumu "Subjektif Global Değerlendirme (SGD)" ile belirlendi. Hastalar ayrıca "Beck Depresyon Görüşmesi" ve "Pittsburg Uyku Kalitesi İndeksi" ile değerlendirildi. Hastaların demografik ve laboratuvar verileri kaydedildi.BulgulAr: SGD sonuçlarına göre, 48 (%65.8) hastanın beslenme durumu iyi düzeyde iken 25 (%34.2) hasta hafif-orta ve ciddi derecede beslenme bozukluğuna sahipti. Beslenme durumu iyi olan hastalar ile malnutrisyonu olan hastalar karşılaştırıldığında, beslenmesi iyi olan grubun daha yüksek albümin (p<0,0001) ve kreatinin (p=0,03) düzeyleri ile vücut kitle indeksine (p<0,01), daha düşük CRP düzeylerine (p<.0001), daha iyi uyku kalitesine (p<0,0001) ve daha düşük depresyon skorlarına (p<0,0001) sahip olduğu görüldü. Hastaları, Grup I (depresyonu olmayan ve iyi uyku kalitesine sahip), Grup II (depresyonu olan ancak iyi uyku kalitesine sahip), Grup III (depresyonu olan ve kötü uyku kalitesine sahip) şeklinde gruplandığımızda Grup III'ün diğer gruplara kıyasla en düşük albümin (p<0,0001) ve en yüksek CRP (p<0,0001) düzeylerine sahip olduğu bulundu.SOnuç: Depresyon, uyku bozuklukları ve beslenme durumu birbirleriyle ilişkili önemli etkenlerdir ve malnutrisyonu olan yaşlı diyaliz has...

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Nutritional Status and Depression, Sleep Disorder, and Quality of Life in Hemodialysis Patients

Cited by 73 publications

References 33 publications

Prevalence of sleep disorders among ESRD patients

Prevalence of sleep disorders among ESRD patients

The role of adipocytokines on depressive symptoms of patients with chronic kidney disease

Association of Nutritional Status with Depression and Sleep Disorders in Elderly End Stage Renal Disease Patients - Does Chronic Inflammation Cause it all?

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