Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease

Choi, Ye Rin; Kim, Hyeong Seop; Yoon, Sang Jun; Lee, Na Young; Gupta, Haripriya; Ganesan, Raja; Gebru, Yoseph Asmelash; Youn, Gi Soo; Kim, Dong Joon; Ham, Young Lim; Suk, Ki Tae

doi:10.3390/nu13010185

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…The gut microbiota plays an ameliorative role in liver diseases. Liver diseases such as fatty liver, hepatitis, and cirrhosis are related to bile acid secretion disorder and metabolic syndrome ( 56 , 86 , 87 ). Table 3 lists the more important metabolites in the human gut microbiome.…”

Section: Gut Microbiota and One Carbon Metabolismsmentioning

confidence: 99%

Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver Disease

et al. 2022

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The gut microbiome and microbial metabolomic influences on liver diseases and their diagnosis, prognosis, and treatment are still controversial. Research studies have provocatively claimed that the gut microbiome, metabolomics understanding, and microbial metabolite screening are key approaches to understanding liver cancer and liver diseases. An advance of logical innovations in metabolomics profiling, the metabolome inclusion, challenges, and the reproducibility of the investigations at every stage are devoted to this domain to link the common molecules across multiple liver diseases, such as fatty liver, hepatitis, and cirrhosis. These molecules are not immediately recognizable because of the huge underlying and synthetic variety present inside the liver cellular metabolome. This review focuses on microenvironmental metabolic stimuli in the gut-liver axis. Microbial small-molecule profiling (i.e., semiquantitative monitoring, metabolic discrimination, target profiling, and untargeted profiling) in biological fluids has been incompletely addressed. Here, we have reviewed the differential expression of the metabolome of short-chain fatty acids (SCFAs), tryptophan, one-carbon metabolism and bile acid, and the gut microbiota effects are summarized and discussed. We further present proof-of-evidence for gut microbiota-based metabolomics that manipulates the host's gut or liver microbes, mechanosensitive metabolite reactions and potential metabolic pathways. We conclude with a forward-looking perspective on future attention to the “dark matter” of the gut microbiota and microbial metabolomics.

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Section: Gut Microbiota and One Carbon Metabolismsmentioning

confidence: 99%

Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver Disease

et al. 2022

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“…19,20 Some women with anemia have poor nutritional status. 21 Lack of energy intake is one of the factors associated with anemia. 7 A study in a school in the city of Padang showed that the prevalence of anemia among adolescents was 49.1%.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Hemoglobin Levels with Nutritional Status in Adolescent Girls: A Health Promotion Perspective

Sari

Silaban

Merry

2023

JPKI

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Background: Women during pregnancy, childbearing age, and adolescents are prone to anemia. The prevalence of anemia in adolescents in Indonesia in 2018 reached 32%. The objectives of this study were to determine the correlation between nutritional status with the incidence of anemia in adolescent girls.Method: Describe briefly the main methods or treatments applied. This study is an analytical survey with a cross-sectional design. The population in this study was student girls in Padang City in 2022.The instrument used to measure hemoglobin was a digital Hb measuring instrument. The nutritional status in this study used the measurement of the nutritional status of adolescents with the indicator of BMI according to age. Correlative analytic test with ordinal scale data used the Kendall's tau test.Results: Based on the results of this study, was known that most of the 71.9% of adolescent girls whose nutritional status is normal. Most of the adolesce girls (87.5%) had normal hemoglobin levels, and as many as 12.5% adolensce girls had anemia who were not menstruating. Nutritional status (BMI/age) and hemoglobin levels were not correlated. Nutritional status is not a factor causing anemia in adolescent girls. It is necessary to investigate the prevalence of anemia in adolescent girls during menstruation as a comparison.

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“…The intestines and liver are, thus, the main organs that are damaged by alcohol. The pathogenesis of ALD is complex, and the existing treatment methods of abstinence, diet, and drug therapy for ALD have some drawbacks [ 6 , 7 , 8 ]. Therefore, exploring the pathogenesis of ALD to identify a suitable treatment for the disease is essential.…”

Section: Introductionmentioning

confidence: 99%

Lonicera Caerulea Juice Alleviates Alcoholic Liver Disease by Regulating Intestinal Flora and the FXR-FGF15 Signaling Pathway

Zhang,

Niu,

Huang

2023

Nutrients

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Alcoholic liver disease (ALD) is a growing public health issue with high financial, social, and medical costs. Lonicera caerulea, which is rich in polyphenolic compounds, has been shown to exert anti-oxidative and anti–inflammatory effects. This study aimed to explore the effects and mechanisms of concentrated Lonicera caerulea juice (LCJ) on ALD in mice. ALD was established in mice via gradient alcohol feeding for 30 days. The mice in the experimental group were given LCJ by gavage. The reduction of aspartate transaminase (AST) and alanine transaminase (ALT) in the serum of mice indicated that LCJ has a liver-protective effect. LCJ improved the expression of AMPK, PPARα, and CPT1b in ALD mice to reduce the liver lipid content. Additionally, LCJ increased the expression of farnesoid X receptor (FXR), fibroblast growth factor 15 (FGF15), and fibroblast growth factor receptor 4 (FGFR4), which lowers the expression of cytochrome P450 7A1 (CYP7A1) and lessens bile acid deposition in the liver. In mice, LCJ improved the intestinal barrier by upregulating the expression of mucins and tight junction proteins in the small intestine. Moreover, it accelerated the restoration of microbial homeostasis in both the large and small intestines and increased short–chain fatty acids in the cecum. In conclusion, LCJ alleviates ALD by reducing liver and serum lipid accumulation and modulating the FXR–FGF15 signaling pathway mediated by gut microbes.

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Nutritional Status and Diet Style Affect Cognitive Function in Alcoholic Liver Disease

Cited by 7 publications

References 38 publications

Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver Disease

Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver Disease

Correlation of Hemoglobin Levels with Nutritional Status in Adolescent Girls: A Health Promotion Perspective

Lonicera Caerulea Juice Alleviates Alcoholic Liver Disease by Regulating Intestinal Flora and the FXR-FGF15 Signaling Pathway

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