Nutritional status, metabolic changes and white blood cells in adolescents

Oliveira, Thatianne Moreira Silva; Faria, Franciane Rocha de; Faria, Eliane Rodrigues de; Pereira, Patrícia Feliciano; Franceschini, Sylvia C. C.; Priore, Sílvia Eloíza

doi:10.1590/s0103-05822014000400011

Cited by 10 publications

(9 citation statements)

References 16 publications

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“…Other studies with healthy adolescents not including CFRD patients have demonstrated the expected positive correlation between WCC and BMI. 55,56 Females have been shown to have higher complication rates in youth with T1D. [57][58][59] In our statistical analyses, gender was not associated with any significant differences in complication status or in inflammatory marker levels.…”

Section: Discussionmentioning

confidence: 53%

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Associations between circulating inflammatory markers, diabetes type and complications in youth

et al. 2019

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Background Inflammation is implicated in the pathogenesis of diabetes and its complications in adults. Little is known about the relative contribution of inflammation in common types of diabetes in youth: type 1 diabetes (T1D), type 2 diabetes (T2D), and cystic fibrosis‐related diabetes (CFRD). This study investigates inflammatory markers by diabetes type and complication status, and assesses indicators of inflammation and complications. Methods A cross‐sectional study of 134 T1D, 32 T2D, 32 CFRD and 48 subjects without diabetes (including 11 with CF and normal glucose tolerance) was undertaken. Inflammation was assessed by sE‐selectin by ELISA, hsCRP by turbidimetry, WCC and ESR. Nephropathy was defined by albuminuria, autonomic neuropathy by heart rate variability, and peripheral neuropathy by vibration and thermal threshold testing and retinopathy by seven‐field stereoscopic fundus photography. Descriptive statistics, parametric and non‐parametric ANOVA and regression analyses were performed, with significance at P < .05. Results Of 198 diabetic participants; 49% female, mean (SD) age, median diabetes duration and median HbA1c were 16 (2.5) and 6 (3–9) years, and 8.1 (6.9‐9.3)%, respectively. All inflammatory markers were lower in T1D than in other diabetes groups (P < .05) but higher than in non‐diabetic controls. T2D (n = 32) and CFRD (n = 32) subjects had comparable elevated levels of inflammation. Body mass index (BMI) was a strong independent explanatory variable of inflammation. In multivariate analysis, hsCRP and ESR were associated with complications in addition to HbA1c, BMI, and diastolic BP. Conclusions Circulating inflammatory markers are elevated in adolescents with diabetes, being higher and comparable in T2D and CFRD than in T1D. Inflammation is independently associated with diabetes complications, consistent with inflammation driving vascular pathology in diabetes.

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Section: Discussionmentioning

confidence: 53%

“…As most underweight subjects were in the CFRD group, this may reflect current and recurrent infections, which may also contribute to their low body weight. Other studies with healthy adolescents not including CFRD patients have demonstrated the expected positive correlation between WCC and BMI …”

Section: Discussionmentioning

confidence: 71%

Associations between circulating inflammatory markers, diabetes type and complications in youth

et al. 2019

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“…Sepsis is a high-risk disease caused by host reaction disorder and endangering the safety of life [ 54 ]. Eosinophils are components of white blood cells of the immune defense system, and play a role in evolution of inflammation and disease [ 55 , 56 ]. FCER1A (Fc fragment of IgE receptor Ia) is an IgE receptor (immunoglobulin receptor), which is the initiating factor of allergic reactions and plays a role in allergic inflammation [ 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Revealing potential diagnostic gene biomarkers of septic shock based on machine learning analysis

Fan

Qiu-feng

et al. 2022

BMC Infect Dis

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Background Sepsis is an inflammatory response caused by infection with pathogenic microorganisms. The body shock caused by it is called septic shock. In view of this, we aimed to identify potential diagnostic gene biomarkers of the disease. Material and methods Firstly, mRNAs expression data sets of septic shock were retrieved and downloaded from the GEO (Gene Expression Omnibus) database for differential expression analysis. Functional enrichment analysis was then used to identify the biological function of DEmRNAs (differentially expressed mRNAs). Machine learning analysis was used to determine the diagnostic gene biomarkers for septic shock. Thirdly, RT-PCR (real-time polymerase chain reaction) verification was performed. Lastly, GSE65682 data set was utilized to further perform diagnostic and prognostic analysis of identified superlative diagnostic gene biomarkers. Results A total of 843 DEmRNAs, including 458 up-regulated and 385 down-regulated DEmRNAs were obtained in septic shock. 15 superlative diagnostic gene biomarkers (such as RAB13, KIF1B, CLEC5A, FCER1A, CACNA2D3, DUSP3, HMGN3, MGST1 and ARHGEF18) for septic shock were identified by machine learning analysis. RF (random forests), SVM (support vector machine) and DT (decision tree) models were used to construct classification models. The accuracy of the DT, SVM and RF models were very high. Interestingly, the RF model had the highest accuracy. It is worth mentioning that ARHGEF18 and FCER1A were related to survival. CACNA2D3 and DUSP3 participated in MAPK signaling pathway to regulate septic shock. Conclusion Identified diagnostic gene biomarkers may be helpful in the diagnosis and therapy of patients with septic shock.

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“…Provavelmente é possível explicar o aumento destas células com base no fator pró-inflamatório que as células adiposas possuem. [15][16][17] A obesidade provoca, por intermédio dos adipócitos, a secreção de uma variedade de adipocinas e proteínas de fase aguda, que podem aumentar a produção e circulação de fatores relacionados à inflamação. Por se tratar de um processo de inflamação constante, as células brancas costumam estar aumentadas.…”

Section: Discussionunclassified

“…Sabe-se que este mecanismo ainda não é plenamente compreendido; no entanto a obesidade está relacionada ao aumento de citocinas circulantes que podem contribuir com o aumento das células brancas circulantes. 16 Nas mulheres, o consumo de proteínas em g/kg/dia apresentou menor associação com o percentual de gordura corporal, em conformidade com o posicionamento da International Society of Sports Nutrition (ISSN) para dietas e composição corporal, por Aragon et al 18 No entanto, trabalhos anteriores encontraram repercussões diferentes, como proposto por Correa-Rodríguez et al, 19 em que foi encontrada associação positiva do consumo proteico com o índice de massa corporal e massa magra, mas ao se avaliar a associação com a massa gorda, não se observaram diferenças estatisticamente significantes.…”

Section: Discussionunclassified

Fatores associados ao elevado percentual de gordura corporal em indivíduos fisicamente ativos

Silveira

Silva

Padilha³

et al. 2021

DEMETRA

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Introdução: O exercício físico é praticado com diversos objetivos, destacando-se a promoção na mudança da composição corporal, com a redução de gordura e aumento de massa magra. Assim, compreender os fatores que podem estar associados nesta modificação se torna relevante. Objetivo: Analisar os fatores demográficos, estilo de vida, bioquímico, alimentares e de treinamento associados ao percentual de gordura corporal em praticantes de exercício físico em academias. Materiais e Métodos: Estudo transversal com 143 praticantes de exercícios físicos saudáveis, de ambos os sexos. Características sociodemográficas e estilo de vida foram obtidas através da aplicação de questionário. O consumo alimentar foi obtido através de registros alimentares de 24h, considerando as médias de três dias. A composição corporal foi avaliada por meio de avaliação antropométrica e pelo teste de bioimpedância elétrica. A análise estatística contemplou o teste de Shapiro Wilk para verificação da normalidade; o qui-quadrado e exato de Fisher foram usados para avaliar a associação entre as variáveis categóricas e a variável resposta e os testes de Mann-Whitney e t de Student para as contínuas. A regressão de Poisson com variância robusta foi usada para determinar as associações entre variáveis estudadas. O software Stata versão 14.0 foi usado para análise estatística, tendo sido adotado o valor de p <0,05. Resultados: A prevalência de gordura corporal elevada foi de 49,3% nos homens e 79,2% nas mulheres. Os fatores associados foram o maior consumo de proteína e fibras nas mulheres e a concentração de monócitos nos homens. Conclusão: Apesar de se tratar de público fisicamente ativo, observou-se elevado percentual de gordura entre os participantes do estudo e os fatores associados reforçam o caráter multietiológico deste indicador.

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Nutritional status, metabolic changes and white blood cells in adolescents

Abstract: Nutritional status is related to an inflammatory process, and adolescents with excess weight or body fat presented higher amounts of white blood cells.

Cited by 10 publications

References 16 publications

Associations between circulating inflammatory markers, diabetes type and complications in youth

Associations between circulating inflammatory markers, diabetes type and complications in youth

Revealing potential diagnostic gene biomarkers of septic shock based on machine learning analysis

Fatores associados ao elevado percentual de gordura corporal em indivíduos fisicamente ativos

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