Nutritional supplements in combination with chemotherapy or targeted therapy reduces tumor progression in mice bearing triple-negative breast cancer

Guo, Chih-Hung; Hsia, Simon; Chung, Chieh-Han; Lin, Yi‐Chun; Shih, Min-Yi; Chen, Pei-Chung; Peng, Chia-Lin; Henning, Susanne M.; Hsu, Guoo-Shyng Wang; Li, Zhaoping

doi:10.1016/j.jnutbio.2020.108504

Cited by 18 publications

(43 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, Se treatment of human breast cancer cells and ovarian cancer cells has been shown to inhibit VEGF and MMP expression [14,24]. TNBC tumor-bearing mice receiving FO/Se had significantly lower tumor VEGF protein expression [15]. Our present results show that treatment with low-dose Avastin combined with FO and Se exerts dose-dependent inhibitory effects on the activation of multiple proangiogenic growth factors/receptors in TNBC tumors.…”

Section: Fo/se and Pro-angiogenic Growth Factors In Tnbcsupporting

confidence: 51%

“…The anti-VEGF agent Avastin (Roche Diagnostics GmbH, Mannheim, Germany) was purchased from commercial sources. As described previously [15], a control-based powder that was free from FO and Se (127.5 mg carbohydrate, 30.0 mg fat, and 65.5 mg protein per Kcal) was purchased from Do Well Laboratories, Inc. (Irvine, CA, USA). The Supplemental marine-based FO and Se yeast (Do Well Laboratories) were mixed with the control powder because these components are generally insoluble in water under normal conditions.…”

Section: Anti-angiogenic Agent and Nutritional Supplementsmentioning

confidence: 99%

“…Nutritional mixtures containing FO and Se may increase the anticancer effects of antitumor agents through several anticancer molecular mechanisms [15]. This study aims at further determining the dose-dependent efficacy of combination treatment using FO and Se with low dose Avastin for improving antitumor effects and the mechanisms of anticancer activity in mice bearing triple-negative 4T1 mammary-carcinoma.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice

et al. 2021

Self Cite

View full text Add to dashboard Cite

Fish oil (FO) and selenium (Se) possess antiangiogenic potential in malignant tumors. This study aimed to determine whether combination of FO and Se enhanced treatment efficacy of low-dose antiangiogenic agent Avastin (bevacizumab) in a dose-dependent manner and targeted multiple signaling pathways in triple-negative breast cancer (TNBC)-bearing mice. Randomized into five groups, mice received treatment with either physiological saline (control), Avastin alone, or Avastin in combination with low, medium, and high doses of FO/Se. The target signaling molecules for anticancer were determined either by measuring protein or mRNA expression. Avastin-treated mice receiving FO/Se showed lower tumor growth and metastasis than did mice treated with Avastin alone. Combination-treated mice exhibited lower expressions in multiple proangiogenic (growth) factors and their membrane receptors, and altered cytoplasmic signaling molecules (PI3K-PTEN-AKT-TSC-mTOR-p70S6K-4EBP1, Ras-Raf-MEK-ERK, c-Src-JAK2-STAT3-TMEPAI-Smad, LKB1-AMPK, and GSK3β/β-catenin). Dose-dependent inhibition of down-stream targets including epithelial-to-mesenchymal transition transcription factors, nuclear cyclin and cyclin-dependent kinases, cancer stem cell markers, heat shock protein (HSP-90), hypoxia-inducible factors (HIF-1α/-2α), matrix metalloprotease (MMP-9), and increased apoptosis were observed. These results suggest that combination treatment with FO and Se increases the therapeutic efficacy of Avastin against TNBC in a dose-dependent manner through multiple signaling pathways in membrane, cytoplasmic, and nucleic targets.

show abstract

Section: Fo/se and Pro-angiogenic Growth Factors In Tnbcsupporting

confidence: 51%

Section: Anti-angiogenic Agent and Nutritional Supplementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The work of Moreno-Vega et al, where they showed the efficacy of I 2 supplementation (alone or combined with chemotherapy) in a 5-year pilot study, showed a 63% increase in disease-free time, a reduction in tumor size, and cytotoxic immune system activation [10]. In this direction, there are many works analyzing the combination of nutrients and chemotherapeutic therapies evidencing synergic interactions which can lead to better outcomes [179,180]. Moreover, guidelines with combinations of different nutrients for cancer patients were commissioned by ESPEN (European Society for Clinical Nutrition and Metabolism) and by the European Partnership for Action Against Cancer (EPAAC) [181].…”

Section: Discussionmentioning

confidence: 99%

Micronutrients and Breast Cancer Progression: A Systematic Review

Cuenca-Micó¹,

Aceves²

2020

Nutrients

View full text Add to dashboard Cite

Epidemiological studies on micronutrient consumption have reported protective associations in the incidence and/or progression of various cancer types. Supplementation with some of these micronutrients has been analyzed, showing chemoprotection, low toxicity, antiproliferation, and the ability to modify epigenetic signatures in various cancer models. This review investigates the reported effects of micronutrient intake or supplementation in breast cancer progression. A PubMed search was conducted with the keywords “micronutrients breast cancer progression”, and the results were analyzed. The selected micronutrients were vitamins (C, D, and E), folic acid, metals (Cu, Fe, Se, and Zn), fatty acids, polyphenols, and iodine. The majority of in vitro models showed antiproliferative, cell-cycle arrest, and antimetastatic effects for almost all the micronutrients analyzed, but these effects do not reflect animal or human studies. Only one clinical trial with vitamin D and one pilot study with molecular iodine showed favorable overall survival and disease-free interval.

show abstract

“…The anticancer effects of these ω3 PUFA have been also demonstrated in vivo. Dietary supplementation with EPA/DHA could contribute to reinforcement of the response to anticancer treatments (chemotherapy and immunotherapy) as in TNBC [32], and also in the basal-like model [33].…”

Section: Type Of Studiesmentioning

confidence: 99%

Link between Omega 3 Fatty Acids Carried by Lipoproteins and Breast Cancer Severity

et al. 2022

View full text Add to dashboard Cite

According to the International Agency for Research on Cancer (IARC) more than 10% of cancers can be explained by inadequate diet and excess body weight. Breast cancer is the most common cancer affecting women. The goal of our study is to clarify the relationship between ω3 fatty acids (FA) carried by different lipoproteins and breast cancer (BC) severity, according to two approaches: through clinic-biological data and through in vitro breast cancer cell models. The clinical study has been performed in sera from a cohort of BC women (n = 140, ICO, France) whose tumors differed by their hormone receptors status (HR− for tumors negative for estrogen receptors and progesterone receptors, HR+ for tumors positive for either estrogen receptors or progesterone receptors) and the level of proliferation markers (Ki-67 ≤ 20% Prolif− and Ki-67 ≥ 30% Prolif+). Lipids and ω3FA have been quantified in whole serum and in apoB-containing lipoproteins (Non-HDL)) or free of it (HDL). Differences between Prolif− and Prolif+ were compared by Wilcoxon test in each sub-group HR+ and HR−. Results are expressed as median [25th–75th percentile]. Plasma cholesterol, triglycerides, HDL-cholesterol and Non-HDL cholesterol did not differ between Prolif− and Prolif+ sub-groups of HR− and HR+ patients. Plasma EPA and DHA concentrations did not differ either. In the HR− group, the distribution of EPA and DHA between HDL and Non-HDL differed significantly, as assessed by a higher ratio between the FA concentration in Non-HDL and HDL in Prolif− vs. Prolif+ patients (0.20 [0.15–0.36] vs. 0.04 [0.02–0.08], p = 0.0001 for EPA and 0.08 [0.04–0.10] vs. 0.04 [0.01–0.07], p = 0.04 for DHA). In this HR− group, a significant increase in Non-HDL EPA concentration was also observed in Prolif− vs. Prolif+ (0.18 [0.13–0.40] vs. 0.05 [0.02–0.07], p = 0.001). A relative enrichment on Non-HDL in EPA and DHA was also observed in Prolif− patients vs. Prolif+ patients, as assessed by a higher molar ratio between FA and apoB (0.12 [0.09–0.18] vs. 0.02 [0.01–0.05], p < 0.0001 for EPA and 1.00 [0.73–1.69 vs. 0.52 [0.14–1.08], p = 0.04 for DHA). These data were partly confirmed by an in vitro approach of proliferation of isolated lipoproteins containing EPA and DHA on MDA-MB-231 (HR−) and MCF-7 (HR+) cell models. Indeed, among all the studied fractions, only the correlation between the EPA concentration of Non-HDL was confirmed in vitro, although with borderline statistical significance (p = 0.07), in MDA-MB-231 cells. Non-HDL DHA, in the same cells model was significantly correlated to proliferation (p = 0.04). This preliminary study suggests a protective effect on breast cancer proliferation of EPA and DHA carried by apo B-containing lipoproteins (Non-HDL), limited to HR− tumors.

show abstract

Nutritional supplements in combination with chemotherapy or targeted therapy reduces tumor progression in mice bearing triple-negative breast cancer

Cited by 18 publications

References 57 publications

Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice

Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice

Micronutrients and Breast Cancer Progression: A Systematic Review

Link between Omega 3 Fatty Acids Carried by Lipoproteins and Breast Cancer Severity

Contact Info

Product

Resources

About