Nutritional Value of Raphia hookeri Fruit, Hematological Properties of Its Powder and Aqueous Extract in A Model of Aluminum Chloride Inducing Neurotoxicity by Using Rats

Doungue, Hermine Tsafack; Kengne, Anne Pascale Nouemsi; Djikeng, Fabrice Tonfack; Teboukeu, Gires Boungo; Womeni, Hilaire Macaire

doi:10.5539/jfr.v9n5p113

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…They had free access to water and food. The staple food (SF) for the animals was composed according to the food composition for animals of Doungue et al ( 2020 ) as follows: maize meal (68%), soybean meal (20%), fish meal (10%), bone meal (1%), cooking salt (0.8%), and vitamin complex (0.1%). The neutral control group received the staple food.…”

Section: Methodsmentioning

confidence: 99%

The effect of soursop‐flower‐enriched fried palm olein on some biochemical and hematological parameters of rats

Loungaing

Djikeng

Teboukeu

et al. 2023

Food Science & Nutrition

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This work set out to, first, assess the role of soursop flower extracts (SFE) in limiting palm olein oxidation during the production of plantain chips, before ascertaining the effect of these soursop‐flower‐enriched fried palm olein on some biochemical and hematological parameters of rats. The extracts were added to 1.5 kg of oil at 1000, 1400, and 1800 ppm, while BHT at 200 ppm served as a positive control (PO+BHT), and the oil without additives was the negative control (PO). The samples were subjected to 15 frying cycles. Total oxidation values varied between 5.94 ± 0.0 and 31.58 ± 0.37; 8.08 ± 0.25 and 28.24 ± 0.00 and 13.71 ± 0.24 and 42.71 ± 0.40 respectively for palm olein enriched with SFE, for PO+BHT and for PO. Twenty‐one groups each comprising five rats received, through dietary supplementation, oils subjected to 0, and 5, 10 and 15 frying cycles for a duration of 30 days. The alanine transaminase and aspartate transaminase of rats fed with oils enriched with SFE at fresh states and at 5 frying cycles was comparable to that of the neutral control group (23.45 ± 2.65 and 93.10 ± 3.53 U/L) and lower than that of the negative control group (52.15 ± 2.01 and 124.07 ± 1.89 U/L). The HDL cholesterol of these animals was also comparable to that of the neutral control group (67.82 ± 4.06 mg/dl) and higher than that of the negative control group (50.25 ± 5.20 mg/dl). White blood cells and mean corpuscular volume of rats fed with fried olein previously enriched with SFE were lower than those fed with fried olein without additives. These extracts are recommended as natural antioxidants for the stabilization of palm olein.

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Section: Methodsmentioning

confidence: 99%

The effect of soursop‐flower‐enriched fried palm olein on some biochemical and hematological parameters of rats

Loungaing

Djikeng

Teboukeu

et al. 2023

Food Science & Nutrition

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Botanical from the Fruits Mesocarp of Raphia vinifera Displays Antiproliferative Activity and Is Harmless as Evidenced by Toxicological Assessments

Nguenang

Mbaveng

Bonsou

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Raphia vinifera is widely used to treat several diseases including digestive disorders, dysentery, and genitourinary infections. In this study, the mineral contents, the cytotoxicity, and the toxicological effect of the crude CHCl3/MeOH extract (RVM) from the mesocarp of Raphia vinifera were evaluated. The mineral contents were evaluated using the method described by the Association of Official Analytical Chemists (AOAC). The cytotoxicity of both extract and chemical compounds from the plants was determined by a resazurin reduction assay (RRA). The toxicological studies were carried out using the experimental procedure of the Organization for Economic Cooperation and Development (OECD). After killing the rats, biochemical, histopathological, and hematological studies were performed. The result indicated that RVM is rich in zinc (6.52 mg/100 g of DM) and sodium (194.5 mg/100 g of DM). RVM had a cytotoxicity effect with IC50 values lower than 30 μg/mL in 18/18 cancer cell lines tested. These recorded IC50 values were between 12.35 µg/mL (toward CCRF-CEM leukemia cells) and 26.66 µg/mL (toward SKMel-505 BRAF wild-type melanoma cells). Raphvinin 4 displayed good cytotoxicity against MaMel-80aBRAF-V600E homozygous mutant with the IC50 of 10.42 μM. RVM was relatively nontoxic to rats, the median lethal dose (DL50) being above 5000 mg/kg body weight. However, during the oral administration period extending for 28 days, precautions should be taken due to the increase in urinary creatinine level and decrease in spleen weight in the male rats given the highest dose (1000 mg/kg) of extract. Conclusively, the extract of Raphia vinifera is weakly toxic in rats and could be further used in the development of anticancer phytomedicines.

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Physiologic Investigation of frequent Administration of Aqueous Extract of Raphia Hookeri Fruit Pulp on Selected Reproductive Hormones in Female Wistar Rats

Egbono, F.F,

Obomanu-Tamunotonjo, R,

Unakalamba E.C

2025

IJARSCT

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This research is aimed at evaluating the effect of frequent consumption of aqueous extract of raphia hookeri fruit pulp on selected reproductive hormones in female Wistar rats. A total of 32 apparently healthy rats weighing 130g to 180g grouped into 4, group1 as control fed with distilled water and feed, group 2 given 500mg/kg, group3 given 1000mg/kg, group 4 given 2000mg/kg body weight of the extract for 28days. Animals sacrificed and blood samples taken for laboratory analysis,results analyzed using statistical tool SPSS version 21.0, one-way ANOVA,P<0.05 considered significant, values expressed as mean, standard error of mean (SEM). Outcome displayed significant (P>0.05) reduction in Estrogenlevels in groups 2 (17.65±1.25) and 3 (23.00±0.00), but group 4 (43.15±3.85) showed a significant increase when compared to control (37.00±4.00). Follicle Stimulating Hormonelevels in all treated groups did not indicate significant (P>0.05) changes when compared to the control group (2.10±0.30), however, group 4 (3.45±1.15) showed a significant increase when compared to groups 2 (0.65±0.25) and 3 (1.00±0.10). No significant (P>0.05) variations in luteinizing hormone levels when treated groups compared to the control group (1.40±0.30), only group 4 (2.25±0.15) indicated significant (P<0.05) increase when compared to groups 2 (0.55±0.45) and 3 (1.35±0.15). Hence, it can be inferred that the frequent consumption of aqueous extract from Raphia Hookeri fruit pulp has the potential to alleviate female reproductive disorders associated with hormonal imbalances or dysfunctions

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Nutritional Value of Raphia hookeri Fruit, Hematological Properties of Its Powder and Aqueous Extract in A Model of Aluminum Chloride Inducing Neurotoxicity by Using Rats

Cited by 3 publications

References 25 publications

The effect of soursop‐flower‐enriched fried palm olein on some biochemical and hematological parameters of rats

The effect of soursop‐flower‐enriched fried palm olein on some biochemical and hematological parameters of rats

Botanical from the Fruits Mesocarp of Raphia vinifera Displays Antiproliferative Activity and Is Harmless as Evidenced by Toxicological Assessments

Physiologic Investigation of frequent Administration of Aqueous Extract of Raphia Hookeri Fruit Pulp on Selected Reproductive Hormones in Female Wistar Rats

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