O-48 Molecular markers in malignant pleural mesothelioma

Gaafar, Rabab; Mokhtar, Nadia; Ismail, Hoda; Elhosseiny, Somaya; Abdelhamid, Thoraya; Abdelrahman, Abdelrahman M.; Eldin, Nelly H. Ali

doi:10.1016/s0169-5002(03)91706-5

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Clinicopathological and Molecular Studies For Malignant Pleu1

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2005

2010

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“…The study concluded that overexpression of EGFR proved to be a poor prognostic marker as it was correlated with lack of clinical benefit, and poor survival. On the contrary, HER-2 does not seem to have role in tumorigenesis in MPM [15].…”

Section: Clinicopathological and Molecular Studies For Malignant Pleumentioning

confidence: 80%

Epidemic of mesothelioma in Egypt

Gaafar

El-Din

2005

Lung Cancer

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Section: Clinicopathological and Molecular Studies For Malignant Pleumentioning

confidence: 80%

Epidemic of mesothelioma in Egypt

Gaafar

El-Din

2005

Lung Cancer

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Epidemiology of mesothelioma in Egypt. A ten-year (1998-2007) multicentre study

Akl¹,

Kaddah²,

Abdelhafeez³

et al. 2010

aoms

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IntroductionMesothelioma is a cancer strongly linked to exposure to carcinogenic minerals, especially asbestos. The aim of the study was to detect the incidence of malignant pleural mesothelioma (MPM) in Egypt, to clarify the impact of occupational and environmental risk factors, and to characterise its demographic features.Material and methodsThey were 584 cases diagnosed as MPM detected in Cairo University Hospitals and National Cancer Institute from 1998 to 2007. Unfortunately, full epidemiological data were only available for 165 cases due to absence of a reliable registration system.ResultsA steady increase in the number of cases was detected, from 24 in 1998, peaking at 82 cases in 2005, followed by a gradual decline (though still high) with 68 cases in 2006 and 51 cases in 2007. Male/female ratio was 1.35/1 (p > 0.05). The occupational exposure to asbestos was 13.9%. Residential exposure plays a major role in two regions, Helwan and Shoubra (27.3% and 20.6% respectively), while in Upper and Lower Egypt the level was 12.7% and 17.5% respectively. Kaplan-Meier survival for sex, residence and the pathological types epithelioid, biphasic and sarcomatoid was insignificant. The median survival for different grades and treatment modalities was significant (P < 0.001).ConclusionsThere was a steady increase in the incidence of MPM from 1998 to 2005 followed by a decline during 2006-2007. Mesothelioma in Egypt is mainly concentrated in areas of high environmental pollution. The decline within the last 2 years may be attributed to recent strict industrial preventive measures. However, a better environmental control programme would benefit Egypt.

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O-48 Molecular markers in malignant pleural mesothelioma

Cited by 2 publications

References 0 publications

Epidemic of mesothelioma in Egypt

Epidemic of mesothelioma in Egypt

Epidemiology of mesothelioma in Egypt. A ten-year (1998-2007) multicentre study

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