O Prolongamento do Intervalo QTc na Admissão está Associado ao Aumento da Mortalidade em Pacientes com SARS-COV-2 durante a Hospitalização

Abstract

Fundamento: O envolvimento cardiovascular associado à infecção por SARS-COV-2 está relacionado a desfechos desfavoráveis durante a internação. Portanto, a medida na admissão do intervalo QTc no eletrocardiograma de 12 derivações pode ser um marcador prognóstico. Objetivo: Identificar a relação entre o prolongamento do QTc na admissão durante a hospitalização e a mortalidade por SARS-COV-2. Método: Estudo observacional baseado em uma coorte retrospectiva de pacientes com infecção confirmada por SARS-COV-2 do

Frequent Cardiovascular Manifestations Associated With SARS Cov-2 Infection: Experience at a Tertiary Hospital In Cali, Colombia

“…Knowledge of cardiovascular involvement is increasing every day, including information recently described in Latin America and Colombia on the identification of arrhythmias or electrocardiographic findings as risk predictors, 30 such as identification of prolonged QT interval in up to 10% of patients at hospital admission, associated with almost double the risk of mortality. 8 In this sense, a 12-lead electrocardiogram enables early detection of findings, which are representative of cardiovascular system dysfunction. Besides, it constitutes an accessible, rapid, and cost-effective test for the care of patients with COVID-19.…”

“…Early electrocardiographic findings are increasingly described as markers of poor prognosis, such as correlations of QT interval prolongation, higher incidence of recent sustained arrhythmias, and the presence of myocardial injury, all of which are associated with worse outcomes. 8,9 Highlighting these findings, this study aimed to identify the frequency of electrocardiographic changes and cardiac arrhythmias, sociodemographic and clinical characteristics, and factors associated with mortality in patients hospitalized with COVID-19 infection in a tertiary care hospital. hospital stay of <24 h, or evidence of cardiorespiratory arrest during their initial care were excluded from the study.…”

Pathophysiological effects of SARS-CoV-2 infection on the cardiovascular system and its clinical manifestations—a mini review

“…At the beginning of the pandemic, a marked prolongation of the QT interval was observed in critically ill patients in ICUs receiving adjuvant therapies, including hydroxychloroquine, with or without concomitant azithromycin ( 81 ). This change in the ECG is associated with increased disease severity, serious cardiac injuries, and high mortality rates ( 82 – 84 ). However, a variety of factors can contribute to cardiac repolarization changes and impact the QT interval ( 85 , 86 ).…”

Revisitando o Intervalo QT: Um Antigo Marcador para uma Nova Doença?

“…13,14 In this journal, Barbosa et al presented the results of an observational study that involved a significant retrospective cohort of 1,296 patients admitted to a tertiary hospital with a diagnosis of SARS-Cov-2 infection from March 2020 to July 31, 2021. 15 Of these, 127 (9, 8%) had a prolonged QTc interval. Mortality and length of hospital stay were higher in this group compared to individuals with normal QTc.…”

“…Nesta revista, Barbosa et al apresentaram os resultados de um estudo observacional que envolveu uma expressiva coorte retrospectiva de 1.296 pacientes admitidos em hospital terciário com o diagnóstico de infecção por SARS-Cov-2 no período de março de 2020 a 31 de julho de 2021. 15 Destes, 127 (9,8%) apresentaram intervalo QTc prolongado. A mortalidade e o tempo de permanência hospitalar forammaiores neste grupo quando comparados aos indivíduos com QTc normal.…”