O uso de antibióticos e as resistências bacterianas: breves notas sobre a sua evolução

Loureiro, Rui J. S.; Roque, Fátima; Rodrigues, António Teixeira; Herdeiro, María Teresa; Ramalheira, Elmano

doi:10.1016/j.rpsp.2015.11.003

Cited by 168 publications

(166 citation statements)

References 39 publications

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“…Another relevant public health problem is bacterial resistance, caused by the excessive use of antibiotics, thus favoring the multiplication and dissemination of resistant bacterial strains, as well as the transmission of resistant microorganisms among humans in hospital environments . Bacterial resistance is responsible for serious clinical and economic consequences related to increased morbidity and mortality due to delays in the administration of effective treatments against infections caused by resistant bacteria . Therefore, the search for new compounds with antibacterial activity becomes a viable alternative.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Trypanocidal and Antibacterial Activities of Essential Oils from Four Species of the Family Annonaceae

Bay

Oliveira

Sales

et al. 2019

Chemistry & Biodiversity

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The objective of this study was to evaluate the chemical composition, and the trypanocidal and antibacterial activities of the essential oils from four species of Annonaceae: Bocageopsis multiflora (Mart.) R.E.Fr., Duguetia quitarensis Benth., Fusaea longifolia (Aubl.) Saff., and Guatteria punctata (Aubl.) R.A.Howard. The chemical composition of the essential oils from the aerial parts yielded 23, 20, 21 and 23 constituents, respectively, which were identified by GC/MS. The trypanocidal activity was evaluated against the amastigote and trypomastigote forms of T. cruzi. The antibacterial activity was evaluated by the microdilution method against enterohemorrhagic Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans, Streptococcus pyogenes, and methicillin‐resistant Staphylococcus aureus. The results of trypanocidal activity showed that the essential oils of the four species were active at the tested concentrations, with G. punctata essential oil being the most active, with IC50=0.029 μg/mL, and selectivity index (SI)=32, being 34 times more active than the reference drug benznidazole. All EOs showed strong antibacterial activity (minimum inhibitory concentrations of 4.68–37.5 μg/mL) against strains of S. mutans.

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Section: Introductionmentioning

confidence: 99%

In Vitro Trypanocidal and Antibacterial Activities of Essential Oils from Four Species of the Family Annonaceae

Bay

Oliveira

Sales

et al. 2019

Chemistry & Biodiversity

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“…Embora não tenha sido avaliada a indicação para o uso de antibacterianos neste estudo, é fato que a utilização desses medicamentos de forma abusiva e desnecessária, implica diretamente no desenvolvimento da resistência bacteriana, acarretando riscos à população (3,4,23).…”

Section: Resultsunclassified

“…Alguns métodos podem ser utilizados para avaliar e controlar o avanço da resistência bacteriana como: 1 -a caracterização do perfil de prescrição dos antibacterianos, principal foco deste estudo; 2 -a elaboração de protocolos terapêuticos para processos infecciosos diversos; 3 -o treinamento e a formação dos prescritores; 4 -a conscientização da população sobre os riscos do uso abusivo de antibacterianos; 5 -a correta higienização das mãos; 6 -o monitoramento de pacientes infectados por bactérias multirresistentes; 7 -a atuação efetiva do farmacêutico clínico no controle da prescrição e dispensação de antibacterianos (3,4,24).…”

Section: Resultsunclassified

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Prescrições De Antibacterianos Em Uma Drogaria Do Município De Tanabi, São Paulo, Brasil

Lima

Silva

Pereira

et al. 2017

Infarma

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Antimicrobial drugs are substances able to prevent the proliferation or death of infectious agents, combating and preventing the dissemination of an infection. The abusive or inappropriate use of these drugs leads to the development of strains of multi-resistant microrganisms. The aim of this study was to describe the antimicrobial drug consumption in a drugstore at Tanabi, São Paulo, Brazil. This is a retrospective, descriptive, exploratory study with a quantitative approach. There were analyzed 128 prescriptions containing antimicrobial drugs dispensed in 2016. 64% of the prescriptions were destined to the female gender. The average age was 46 ± 25 years. The most prescribed antimicrobials were cephalexin (23%), amoxicillin associated with clavulanate (22%), ciprofloxacin (17%) and azithromycin (15%). Consequently, the most commonly used pharmacological groups were beta-lactams (55%), fluoroquinolones (30%) and macrolides (15%), respectively. The most frequent prescribers were general phisicians (42%), dentist (12%), cardiologist (9%) and urologist (7%). Most of the prescriptions came from the private health system (54%). The prescribers used the trade name in 55% of the prescribed antimicrobials, of which 33% were destined to the public health system. This research contributes to evaluation of the use of antimicrobial drugs in population. The effective action of the Pharmacist in the control the use of antibacterials in accordance with current legislation is important to provide the population with adequate guidelines on the rational use of these agents.

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“…1 This has led to intensified research involving the synthesis and evaluation of heterocyclic derivatives with antimicrobial properties, such as 1,2,4-oxadiazoles. 2 The indiscriminate use of antibiotics is pointed out as one of the main causes for the development of bacterial resistance. The growth of bacterial resistance has caused the mortality of an expressive number of people worldwide.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Evaluation of 3,5-Diaryl-1,2,4-oxadiazole Derivatives

Cunha¹,

Nogueira²,

Aguiar³

2018

J. Braz. Chem. Soc.

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This manuscript reports the synthesis of twenty 3,5-diaryl-1,2,4-oxadiazole derivatives, nine of which are novel compounds. The amidoxime reaction with acyl chlorides obtained from substituted benzoic acids was used. All compounds were tested against five standard (American Type Culture Collection (ATCC)) bacteria: Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Proteus mirabilis and Staphylococcus aureus. Screening assays were carried out using agardiffusion technique, in which 100 μM heterocyclic compounds solutions (20% dimethylsulfoxide/ water) were employed. The minimum inhibitory concentrations (MIC) of the active compounds were determined by serial dilutions at decreasing concentrations in microtiter plates. The nitrated derivatives gave the best test results, where MIC = 60 μM (E. coli) was the lowest value found for an ortho-nitrated derivative. The activity of these compounds possibly involves a mechanism via free radicals. S. aureus and P. aeruginosa were resistant to all compounds.

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O uso de antibióticos e as resistências bacterianas: breves notas sobre a sua evolução

Cited by 168 publications

References 39 publications

In Vitro Trypanocidal and Antibacterial Activities of Essential Oils from Four Species of the Family Annonaceae

In Vitro Trypanocidal and Antibacterial Activities of Essential Oils from Four Species of the Family Annonaceae

Prescrições De Antibacterianos Em Uma Drogaria Do Município De Tanabi, São Paulo, Brasil

Synthesis and Antibacterial Evaluation of 3,5-Diaryl-1,2,4-oxadiazole Derivatives

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