O3‐11‐05: Disentangling the Temporal Sequence of Subjective Cognitive Decline, Depressive Symptoms and Memory Deterioration: A Trivariate Latent Difference Score Analysis

Kleineidam, Luca; Guski, Jannis; Miebach, Lisa; Wolfsgruber, Steffen; Bickel, Horst; Weyerer, Siegfried; Pentzek, Michael; Wiese, Birgitt; König, Hans‐Helmut; Jessen, Frank; Maier, Wolfgang; Scherer, Martin; Riedel‐Heller, Steffi G.; Heser, Kathrin; Wagner, Michael

doi:10.1016/j.jalz.2019.06.4688

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“…discussed previously, are critical to understanding the temporal unfolding of relations among brain changes in AD, depression, and SCD 3 . A recent longitudinal analysis from the German Study on Aging, Cognition, and Dementia found that higher levels of SCD preceded both future objective memory decline and an increase in depression symptoms, suggesting that screening for SCD and depression symptoms may be particularly important in preclinical AD samples 40 …”

Section: Discussionmentioning

confidence: 99%

Depression screening in cognitively normal older adults: Measurement bias according to subjective memory decline, brain amyloid burden, cognitive function, and sex

Thompson

Jones

2020

Alzheimer's & Dementia: Diagnosis, Assessment &

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Introduction Understanding the associations among depression, subjective cognitive decline, and prodromal Alzheimer's disease (AD) has important implications for both depression and dementia screening in older adults. The Geriatric Depression Scale (GDS) is a depression screening tool for older adults that queries memory concerns. To determine whether depression symptoms on the GDS (15‐item version), including self‐reported memory problems, differ by levels of brain amyloid beta (Aβ), a pathological hallmark of early stage AD, we investigated potential measurement bias with regard to Aβ level. We also examined measurement bias attributable to level of cognitive functioning and sex as positive controls. Methods We examined 3961 cognitively normal older adults from the A4/LEARN Study. We used the MIMIC (multiple indicators, multiple causes) approach to detect measurement bias. Results We found measurement bias with small‐to‐moderate range effect sizes in several GDS‐15 items with respect to Aβ level, cognitive functioning, and sex. There was negligible impact of measurement bias attributable to Aβ level on overall depressive symptom level. Discussion GDS‐15 item responses are sensitive to Aβ burden, cognitive functioning, and sex over and above what would be expected given the effect of those factors on depressive symptom severity overall. However, these direct effects for GDS item measurement bias are of small magnitude and do not appreciably impact the validity of inferences about depression based on the GDS‐15.

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Section: Discussionmentioning

confidence: 99%