O34: Case- control study to identify deviations in gait and physical examination in children and adolescents with Dravet syndrome

Wyers, Lore; Walle, Patricia Van de; Verheyen, Karen; Ceulemans, Berten; Desloovere, Kaat; Hallemans, Ann

doi:10.1016/j.gaitpost.2017.06.288

Cited by 2 publications

(14 citation statements)

References 4 publications

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“…Three full-length articles (7,18,19) , two short notes (20,21) and four conference abstracts University Hospital, Belgium (22,24,25) . The other research groups were situated in Australia (7) , France (19) and Italy (23) .…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Gait was the primary outcome of this review and was assessed using different methods. Three studies evaluated gait by means of clinical observation (18,19,21) , three studies used video analysis (7,20,23) and three studies performed instrumented 3D gait analysis (22,24,25) (table 2).…”

Section: Primary Outcomementioning

confidence: 99%

“…Kinematics study the position and motion of body segments and joints in the three anatomical planes. The participants from the Antwerp study cohort were tested using instrumented 3D gait analysis and compared to age-matched typically developing children based on mean kinematic parameters (22) , mean kinematic time profiles (24) and Gait Profile Scores (25) (table 3).…”

Section: Kinematicsmentioning

confidence: 99%

Section: Kinematicsmentioning

confidence: 99%

“…Concerning the hip, increased flexion was found at initial contact (22) , during stance (24) and in swing (22) , as well as increased adduction in midstance (22) . Increased knee flexion was measured in different parts of the stance phase (22,24) and in swing (22) . At the level of the ankle, increased dorsiflexion in stance (22) , around push-off (24) and in swing (22) were observed, as well as overall increased external rotation of the ankle (24) .…”

Section: Kinematicsmentioning

confidence: 99%

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Gait deviations in patients with dravet syndrome: A systematic review

Wyers

Walle

Hoornweg

et al. 2019

European Journal of Paediatric Neurology

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Background: Dravet Syndrome is a rare developmental epileptic encephalopathy characterised by epileptic seizures, cognitive impairment and motor disorders. Gait is markedly impaired and could benefit from targeted intervention to improve quality of life for patient and caregivers.Objective: To establish the state of the art regarding gait deviations in patients with Dravet Syndrome.Methods: A systematic search was performed in Pubmed, Web of Science, Science Direct and Embase. Studies that assessed gait deviations in patients diagnosed with Dravet Syndrome using clinical observation, video gait analysis or three dimensional (3D) gait analysis and reported gait characteristics, spatiotemporal or kinematic outcomes were included. Screening, quality assessment and data extraction were performed by independent reviewers.Results: Out of a total of 478 citations, nine articles were included. The total study population had an age range from 2.5 to 47 years. Three studies used clinical observation, three studies video analysis and three studies 3D gait analysis. Crouch gait was observed in about half of the population next to a variety of other gait deviations such as parkinsonian and cerebellar gait. Other findings included abnormalities in spatiotemporal parameters and kinematics, passive knee extension deficits, skeletal malalignment and neurological signs. Conclusions:A variety of gait characteristics was observed with crouch gait being the most reported gait pattern. Inconsistency in methods and findings from clinical and instrumented evaluation impede thorough understanding of the causal mechanism and evolution behind these deviations.

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