Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice

Abstract

Ulcerative colitis is a major inflammatory bowel disease (IBD), characterized by inflammation within the gastrointestinal tract through chronic or relapsing immune system activation. The aim of this study is to investigate the potential protective effect of oat β-glucan (βG) against colitis induced by DSS in mice. Eighty mice were randomly divided into the control group (no DSS, no βG), DSS group (DSS only), DSS + L-βG group (DSS plus 500 mg per kg βG), and DSS + H-βG group (DSS plus 1000 mg per kg βG). Compared with the DSS group, administration of βG significantly reduced clinical symptoms with less weight loss, diarrhea and shortening of the colon, the severity of colitis was significantly inhibited as evidenced by the reduced disease activity index (DAI) and degree of histological damage in colon. Moreover, treatment with βG not only decreased myeloperoxidase activity (MPO), and nitric oxide (NO) and malondialdehyde (MDA) levels, but also inhibited mRNA and protein expression of pro-inflammatory factors such as TNF-α, IL-1β, IL-6 and iNOS. This suggests that oat βG in diet might exhibit an anti-inflammatory function against colitis through inhibition of expression of pro-inflammatory factors.

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

“…This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited Inflammatory cell infiltration (mainly macrophages and neutrophils) during acute inflammation increases the formation of ROS and proinflammatory cytokines, such as TNF-α, IL-6, IL-1β, and inducible nitric oxide synthase (iNOS) (7,8). Overproduction of ROS, NO, and PGE2 leads to increased lipid peroxidation, decreased intestinal epithelial barrier integrity, and ultimately mucosal disruption and ulceration (9,10).…”

Crude extract of Fuzhuan brick tea ameliorates DSS‐induced colitis in mice

“…Mice in low-FBT and high-FBT group received 30 or 60 mg kg À1 bw FBT, respectively. Colitis was induced by administration of 3% (w/v) DSS in drinking water for 7 days as described in our previous study (Liu et al, 2015a). Control group, DSS+low-FBT group and DSS+high-FBT group were intragastrically treated with FBT or water for 7 days before dextran sulphate sodium (DSS) (Sigma-Aldrich, Munich, Germany) treatment.…”

New Trends in the Dietary Treatment of Inflammatory Bowel Diseases

“…Badanie Liu et al [47] wykazało, że u myszy, u których wywoływano CU za pomocą DDS (dextran sulfate sodium) podaż β-glukanów w dawce 500 mg/kg m.c./dobę zmniejszyła nasilenie klinicznych objawów choroby. W porówna-niu z grupą kontrolną zwierzęta karmione paszą z dodatkiem β-glukanów miały mniejszą utratę masy ciała, rzadziej występowały u nich biegunki, a w badaniach histopatologicznych mniej nasilone zapalenie okrężnicy.…”