Obésité et cancer

Lauby‐Secretan, Béatrice; Dossus, Laure; Marant-Micallef, Claire; His, Mathilde

doi:10.1016/j.bulcan.2019.04.008

Cited by 27 publications

(24 citation statements)

References 58 publications

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“…Similarly, the increased glutamine metabolism, glutaminolysis, sustains the mitochondrial tricarboxylic acid (TCA) cycle by generation of citrate and αketoglutarate [80]. Moreover, the role of lipid metabolism in cancer is receiving more and more attention, and thus, several studies show that FAs and/or cholesterols promote tumoral activity [81][82][83][84][85][86]. The multiple functions of lipids in cell signalling, membrane components, and sources of energy are essential in cancer cells [87].…”

Section: Lipid Metabolic Reprogrammingmentioning

confidence: 99%

Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

Sangineto

Villani

Cavallone

et al. 2020

Cancers

114

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Metabolic reprogramming is critically involved in the development and progression of cancer. In particular, lipid metabolism has been investigated as a source of energy, micro-environmental adaptation, and cell signalling in neoplastic cells. However, the specific role of lipid metabolism dysregulation in hepatocellular carcinoma (HCC) has not been widely described yet. Alterations in fatty acid synthesis, β-oxidation, and cellular lipidic composition contribute to initiation and progression of HCC. The aim of this review is to elucidate the mechanisms by which lipid metabolism is involved in hepatocarcinogenesis and tumour adaptation to different conditions, focusing on the transcriptional aberrations with new insights in lipidomics and lipid zonation. This will help detect new putative therapeutic approaches in the second most frequent cause of cancer-related death.

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Section: Lipid Metabolic Reprogrammingmentioning

confidence: 99%

Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

Sangineto

Villani

Cavallone

et al. 2020

Cancers

114

View full text Add to dashboard Cite

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“…Furthermore, the link between obstructive sleep apnea and obesity has been recognized for a long time [8]. Reviews of available epidemiological data reiterate the existence of a significant association between obesity and increased risk for several cancers [9]. With the epidemic proportions achieved by the prevalence of obesity worldwide, it is crucial that we fully understand the factors that can control the development of this disease.…”

Section: Introductionmentioning

confidence: 99%

Mass Spectrometry-Based Metabolomics Analysis of Obese Patients’ Blood Plasma

Lokhov

Balashova

Trifonova

et al. 2020

IJMS

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Scientists currently use only a small portion of the information contained in the blood metabolome. The identification of metabolites is a huge challenge because only highly abundant and well-separated compounds can be easily identified in complex samples. However, new approaches that enhance the identification of compounds have emerged; among them, the identification of compounds based on their involvement in a particular biological context is a recent development. In this work, this approach was first applied to identify metabolites in complex samples and, together with metabolite set enrichment analysis, was used for the evaluation of blood plasma from obese patients. The proposed approach was found to provide a statistically sound overview of the biochemical pathways, thus presenting additional information on obesity. Obesity progression was demonstrated to be accompanied by marked alterations in steroidogenesis, androstenedione metabolism, and androgen and estrogen metabolism. The findings of this study suggest that the workflow used for blood analysis is sufficient to demonstrate obesity at the biochemical pathway level as well as to monitor the response to treatment. This workflow is also expected to be suitable for studying other metabolic diseases.

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“…Obesity has been known to be a cause of wide range of complications due to several underlying pathophysiological processes. Comorbidities of obesity are diverse and can occur in many bodily systems including cardiovascular complications, type 2 diabetes mellitus (T2DM), non-alcoholic steatohepatitis (NASH), metabolic syndrome, and several other lesser known morbidities ( Sodhi et al., 2015 ; Srikanthan et al., 2016 ; Fruh, 2017 ; Lakhani et al., 2018 ; Lauby-Secretan et al., 2019 ). The trigger for obesity and associated comorbidities is intricately linked with an increase in reactive oxygen species (ROS) and subsequent oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities

et al. 2020

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Obesity has been a worldwide epidemic for decades. Despite the abundant increase in knowledge regarding the etiology and pathogenesis of obesity, the prevalence continues to rise with estimates predicting considerably higher numbers by the year 2030. Obesity is characterized by an abnormal lipid accumulation, however, the physiological consequences of obesity are far more concerning. The development of the obesity phenotype constitutes dramatic alterations in adipocytes, along with several other cellular mechanisms which causes substantial increase in systemic oxidative stress mediated by reactive oxygen species (ROS). These alterations promote a chronic state of inflammation in the body caused by the redox imbalance. Together, the systemic oxidative stress and chronic inflammation plays a vital role in maintaining the obese state and exacerbating onset of cardiovascular complications, Type II diabetes mellitus, dyslipidemia, non-alcoholic steatohepatitis, and other conditions where obesity has been linked as a significant risk factor. Because of the apparent role of oxidative stress in the pathogenesis of obesity, there has been a growing interest in attenuating the pro-oxidant state in obesity. Hence, this review aims to highlight the therapeutic role of antioxidants, agents that negate pro-oxidant state of cells, in ameliorating obesity and associated comorbidities. More specifically, this review will explore how various antioxidants target unique and diverse pathways to exhibit an antioxidant defense mechanism.

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Obésité et cancer

Cited by 27 publications

References 58 publications

Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

Mass Spectrometry-Based Metabolomics Analysis of Obese Patients’ Blood Plasma

Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities

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