Obesity and osteoporosis

Шишкова, В Н

doi:10.14341/osteo2011121-26

Cited by 5 publications

(5 citation statements)

References 60 publications

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“…Recently, more evidence has pointed to the formation of PRMT oligomers between different PRMT members. Type II PRMT5 and most type I PRMT enzymes except PRMT4 methylate substrates containing glycine and arginine (GAR) [18,19]. The residues distal to the GAR motif can modulate the methylation efficiency, which has been shown in both PRMT1 and 5 [20,21].…”

Section: Prmt Enzymes and Non-histone Substratesmentioning

confidence: 99%

“…Thus, arginine methylation has profound impacts on protein-DNA/RNA and protein-protein interactions, consequently modulating innumerable biological pathways. Applications of bioorthogonal profiling of protein methylation and global proteomic profiling have greatly advanced the identification of the physiological substrates of individual PRMT isoforms [18,[28][29][30]. However, the functional study of specific arginine methylation remains underexplored.…”

Section: Prmt Enzymes and Non-histone Substratesmentioning

confidence: 99%

“…)-PRMT4, also known as CARM1 (coactivator-associated arginine methyltransferase 1), is predominantly located in the nucleus and normally has a positive impact on transcription. PRMT4 consists of a unique N-terminal EVH1 domain (residues 28-140) that can bind to proline-rich sequence [18], which is necessary to substrate recognition and catalytic activity of PRMT4. This also explains why PRMT4 preferentially recognizes arginine residues in PGM-enriched sequences.…”

Section: Prmt4 (Carm1mentioning

confidence: 99%

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Non-Histone Arginine Methylation by Protein Arginine Methyltransferases

Al-Hamashi

Diaz

Huang

2020

CPPS

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: Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing, DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent post-transitional modification of histones and various non-histone proteins that can either activate or repress gene expression. The aberrant expression of PRMTs has been linked to multiple abnormalities, notably cancer. Herein, we review a number of non-histone protein substrates for all nine members of human PRMTs and how PRMT-mediated non-histone arginine methylation modulates various diseases. Additionally, we highlight the most recent clinical studies for several PRMT inhibitors.

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Section: Prmt Enzymes and Non-histone Substratesmentioning

confidence: 99%

Section: Prmt Enzymes and Non-histone Substratesmentioning

confidence: 99%

Section: Prmt4 (Carm1mentioning

confidence: 99%

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Non-Histone Arginine Methylation by Protein Arginine Methyltransferases

Al-Hamashi

Diaz

Huang

2020

CPPS

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“…Ожиріння належить до числа найпоширеніших хронічних захворювань у світі і сягає масштабів неінфекційної епідемії [1]. Надмірна кількість вісцерального жиру є морфологічним субстратом інсулінорезистентності і головним критерієм метаболічного синдрому, а також фактором ризику розвитку таких тяжких захворювань, як цукровий діабет 2-го типу, атеросклероз, ішемічна хвороба серця, артеріальна гіпертензія, ішемічний інсульт, рак ободової кишки, рак грудної залози, рак ендометрія та остеоартроз, до того ж чинить негативний вплив на психологічне здоров'я людей та якість їхнього життя [2].…”

Section: н а д о п о м о г у л і к а р ю -п р а к т и к уunclassified

Features of the Course and Treatment of Osteoarthritis in Patients with Osteoporosis and Obesity

Tsymbaliuk

Krylova

Dubkova

2021

FMEP

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The objective: features of the course and clinical manifestations of the joint syndrome and increase the effectiveness of treatment in patients with OA with osteoporosis and obesity. Materials and methods. The study included 134 patients (88 women and 46 men), aged 30 to 80 years. Depending on the body mass index, patients were divided into 2 groups: obese and normal weight. Peculiarities of the course and effectiveness of treatment were assessed using questionnaires VAS, WOMAC, Lekens. Levels of nonspecific inflammatory parameters (ESR and CRP), cytokines (IL-1, IGF-1, NO), uric acid level and bone mineral density were also studied. SPSS Statistics was used for statistical data processing. Results. The study revealed a statistically significant difference in the indicators of the questionnaires VAS, WOMAC and Leken, levels of immunological (IL-1, IGF-1, NO) and nonspecific (ESR, CRP) indicators of inflammation between the 2 groups of patients. Patients with osteoporosis and obesity had the worst questionnaires and indicators of inflammation, compared with patients with normal BMD and osteopenia. In obese patients, the dynamics of treatment was significantly worse, according to questionnaires, immunological and nonspecific indicators of inflammation. Conclusions. Patients with OA and obesity, compared with normal weight, had more severe joint damage, more intense pain, stiffness and reduced functional activity, as well as more intense inflammation. The most severe course of the disease was observed in patients with osteoporosis and obesity, compared with normal BMD and osteopenia. The dynamics of SYSADOA treatment is impaired in patients with osteoarthritis and obesity: less intense reduction of knee stiffness, pain and poorer functional activity, as well as less effective anti-inflammatory effect.

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“…ИМТ в подростковом возрасте может отразиться на пике формирования костной массы, что впоследствии может сказаться на МПК в репродуктивном возрасте. Так, по данным Шишковой подростки с ожирением могут не достигать пика костной массы, что увеличивает последующий риск переломов во взрослом возрасте [11]. Однако в настоящем исследовании, ожирение в подростковом возрасте по анамнестическим данным не встречалось, а дефицит массы тела выявлен только в 1 группе, у 11 пациенток.…”

Section: обсуждение основного результата исследованияunclassified

Factors influencing bone mineral density in postpartum women

et al. 2018

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Background: Osteopenia is a common condition. Therefore, identification of groups for prevention of osteoporosis and restoration of bone mineral density (BMD) remains relevant. Aim: to assess the factors contributing to development of osteopenia in puerperas. Methods: prospective cross-sectional study. We examined 112 patients aged 20-35, 3-5 days after delivery. To assess possible factors for BMD decrease, we analyzed medical history, lifestyle, nutrition, anthropometric data, obstetric and gynecological history, and pregnancy course. We also assessed serum levels of 25-hydroxycalciferol (25-OH-D) and PTH. BMD was measured by dual energy x-ray osteodensitometry. We considered Z-score from -1 to -2.5SD as osteopenia, below -2.5 SD-as osteoporosis. Results: based on Z-score values, two groups were formed: 1 (n=70) - puerperas with osteopenia, 2 (n=42) - puerperas with normal BMD. In the first group, osteopenia in the distal radius was observed in 48%, in the lumbar spine in 16% and in the proximal femur in 36%. Influence of the following possible factors in group 1 was established: BMI in 15-20 years ≤ 18 kg/m2 (p<0.013), BMI ≥ 25 kg/m2 (p<0.018), 25-OH-D less than 25 ng / ml (p < 0.0018), calcium intake less than 800 mg/day (p<0.041). Menstrual disorders (p<0.052) and preeclapsia (p < 0.042) affected lumbar spine BMD. In group 1, vitamin D deficiency was detected in 82% of women, 18% showed vitamin D insufficiency; in group 2, vitamin D deficiency was found in 16%, deficiency in 70%, in 14% vitamin D was normal. In women with a combination of factors such as BMI≤ 18 kg/m; calcium intake lower than 800 mg/day, menstrual cycle disorders, vitamin D deficiency - osteopenia in the distal radius occured 11 times more often (OR=11,47059; CI 95%=[4,0326; 32,627]). Conclusion: most significant impact on BMD decrease in puerperas can be expected if patient has the following risk factors: BMI≤18 kg/m2; 25-OH- D<25 ng/ml ; nutrition with calcium intake <800 mg per day, preeclampsia. Combination of these factors may increase the risk of osteopenia in the distal radius.

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Obesity and osteoporosis

Cited by 5 publications

References 60 publications

Non-Histone Arginine Methylation by Protein Arginine Methyltransferases

Non-Histone Arginine Methylation by Protein Arginine Methyltransferases

Features of the Course and Treatment of Osteoarthritis in Patients with Osteoporosis and Obesity

Factors influencing bone mineral density in postpartum women

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