Obesity-Associated Hypertension

Rahmouni, Kamal

doi:10.1161/hypertensionaha.114.00920

Cited by 100 publications

(43 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have explored potential mechanisms linking adiposity and high BP, including sympathetic nervous system activation, activation of the renin-angiotensin system, inflammatory responses and insulin resistance (11) . However, few studies explored the influence of an unfavourable blood lipid profile.…”

mentioning

confidence: 99%

The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children

et al. 2016

View full text Add to dashboard Cite

We aimed to examine the contribution of blood lipids to the association between BMI and blood pressure (BP) in children with overweight and obesity. Data were collected in elementary and high schools of Chaoyang District, Beijing, China in 2012. Participants' weight, height, BP and fasting plasma lipid profile were measured by standard protocols. Mediation analysis was used to examine the mediation role of blood lipids on the relation between BMI and BP, with age included as a covariate. We found that in boys 8·29 % (mediation effect = 0·106, P = 0·012) of the association between BMI and systolic BP was mediated through TAG. TAG mediated 12·53 % (mediation effect = 0·093, P = 0·018) and LDL-cholesterol mediated 7·75 % (mediation effect = 0·57, P = 0·046) of the association between BMI and diastolic BP was mediated by TAG and LDL-cholesterol, respectively. However, blood lipids did not show the mediation effect in girls. Our findings suggested that there was a sex difference in the contribution of blood lipids to the association between BMI and BP. Controlling TAG or LDL-cholesterol may be beneficial for reducing the risk of the BMI-related high BP in overweight boys; however, this outcome is not the case when controlling TAG or LDL-cholesterol in girls. This study may provide clues to explore the underlying mechanism of the association between obesity and hypertension.

show abstract

mentioning

confidence: 99%

The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children

et al. 2016

View full text Add to dashboard Cite

show abstract

“…(28) The association between arterial hypertension and obesity was proven in different studies. (29,30) In this sample, eutrophic people showed a 4.11 times higher probability of adhering to the treatment than obese participants. Obesity reduces the treatment adherence.…”

Section: Discussionmentioning

confidence: 79%

Prevalência e fatores associados a cooperação do paciente portador de hipertensão arterial

et al. 2015

View full text Add to dashboard Cite

Objective: To analyze the prevalence and factors associated with the cooperation of arterial hypertension patients in primary health care. Methods: Cross-sectional study that included 458 hypertensive patients, randomly selected among primary care users. The study variables were socioeconomic, demographic and clinical and the research instruments used were validated. The logistic regression model was used for multivariate statistical analysis. Results: The prevalence rates found for patient cooperation corresponded to 26.6%, 16.6% and 85.6% on the Morisky-Green, Batalla and Haynes-Sackett tests, respectively. The adjusted logistic regression analysis showed economic class and smoking as the independent predictors of hypertensive patients' cooperation. Conclusion: The prevalence of treatment adherence varied according to the assessment instrument used. The factors associated with treatment adherence were: high socioeconomic class, living with a partner and being eutrophic. ResumoObjetivo: Analisar a prevalência e os fatores associados a cooperação do paciente portador de hipertensão arterial na atenção primária. Métodos: Estudo transversal que incluiu com 458 hipertensos selecionados aleatoriamente entre os usuários na assistência primária. As variáveis de estudo foram socioeconômicas, demográficas e clínicas e os instrumentos de pesquisa utilizados eram validados. Foi utilizado o modelo de regressão logística para análise estatística multivariada. Resultados: As prevalências encontradas para cooperação do paciente foram 26,6%, 16,6% e 85,6% para os testes de Morisky-Green, Batalla e Haynes-Sackett, respectivamente. Análise de regressão logística ajustada mostrou classe econômica e fumo como os preditores independentes para a cooperação do paciente portador de hipertensão arterial. Conclusão: A prevalência de adesão ao tratamento variou de acordo com o instrumento de avaliação utilizado. Os fatores associados à adesão ao tratamento foram: classe socioeconômica elevada, morar com companheiro e ser eutrófico. Keywords

show abstract

“…However, the mechanisms linking obesity and hypertension are not fully understood (7,44). A number of neuroendocrine systems controlling energy homeostasis also regulate blood pressure and heart rate, including leptin, the melanocortin system, and ghrelin (12, 36, 45, 48 -50).…”

Section: Mk-5046 a Bombesin-like Receptor 3 (Brs-3) Agonist Increasmentioning

confidence: 99%

Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism

Lateef

Xiao

Brychta

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Lateef DM, Xiao C, Brychta RJ, Diedrich A, Schnermann J, Reitman ML. Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism. Am J Physiol Heart Circ Physiol 310: H891-H898, 2016. First published January 22, 2016; doi:10.1152/ajpheart.00963.2015.-Bombesin-like receptor 3 (BRS-3) is an orphan G protein-coupled receptor that regulates energy expenditure, food intake, and body weight. We examined the effects of BRS-3 deletion and activation on blood pressure and heart rate. In free-living, telemetered Brs3 null mice the resting heart rate was 10% lower than wild-type controls, while the resting mean arterial pressure was unchanged. During physical activity, the heart rate and blood pressure increased more in Brs3 null mice, reaching a similar heart rate and higher mean arterial pressure than control mice. When sympathetic input was blocked with propranolol, the heart rate of Brs3 null mice was unchanged, while the heart rate in control mice was reduced to the level of the null mice. The intrinsic heart rate, measured after both sympathetic and parasympathetic blockade, was similar in Brs3 null and control mice. Intravenous infusion of the BRS-3 agonist MK-5046 increased mean arterial pressure and heart rate in wild-type but not in Brs3 null mice, and this increase was blocked by pretreatment with clonidine, a sympatholytic, centrally acting ␣ 2-adrenergic agonist. In anesthetized mice, hypothalamic infusion of MK-5046 also increased both mean arterial pressure and heart rate. Taken together, these data demonstrate that BRS-3 contributes to resting cardiac sympathetic tone, but is not required for activity-induced increases in heart rate and blood pressure. The data suggest that BRS-3 activation increases heart rate and blood pressure via a central sympathetic mechanism.bombesin-like receptor 3; blood pressure; heart rate; sympathetic nervous system; energy metabolism NEW & NOTEWORTHY MK-5046, a bombesin-like receptor 3 (BRS-3) agonist, increases heart rate and blood pressure via increased central sympathetic tone. Brs3 null mice have a reduced resting heart rate that increases disproportionately with physical activity. BRS-3 contributes to the central regulation of heart rate and blood pressure.OBESITY is strongly associated with cardiovascular risk factors, including hypertension (6). However, the mechanisms linking obesity and hypertension are not fully understood (7,44). A number of neuroendocrine systems controlling energy homeostasis also regulate blood pressure and heart rate, including leptin, the melanocortin system, and ghrelin (12, 36, 45, 48 -50). The genetic and pharmacological manipulations of these systems that reduce adiposity generally also increase blood pressure, which is undesirable in a treatment for obesity.Bombesin-like receptor 3 (BRS-3) is a G protein-coupled receptor for which the endogenous ligand is unidentified (4,21,29,33). Despite the name, BRS-3 has a low affinity for bombesin and the related molecules, neuromedin B and gastrin-releasing ...

show abstract

Obesity-Associated Hypertension

Cited by 100 publications

References 79 publications

The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children

The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children

Prevalência e fatores associados a cooperação do paciente portador de hipertensão arterial

Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism

Contact Info

Product

Resources

About