Obesity in adolescents does not influence early immune responses to influenza vaccination

Kristinsdóttir, Íris Mýrdal; Haraldsson, Ásgeir; Brynjólfsson, Siggeir F.; Helgason, Tryggvi; Lúðvíksson, Björn Rúnar; Gianchecchi, Elena; Razzano, Ilaria; Montomoli, Emanuele; Thors, Valtýr

doi:10.1080/23744235.2023.2195491

Cited by 1 publication

(4 citation statements)

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“…Our team has also published a study comparing healthy and adolescents with obesity using the same methodology. 14 This approach provides data on both the general immunological recovery and possible protection against seasonal influenza.…”

Section: Discussionmentioning

confidence: 99%

“…We evaluated the immune responses of childhood cancer survivors to influenza immunisation by measuring both humoral and cellular responses. Our team has also published a study comparing healthy and adolescents with obesity using the same methodology 14 . This approach provides data on both the general immunological recovery and possible protection against seasonal influenza.…”

Section: Discussionmentioning

confidence: 99%

“…Cellular responses to the influenza immunisation were evaluated using T‐cell stimulation assays where T‐cells were stimulated in vitro with influenza antigens (VisMederi Srl, Siena, Italy). Single‐cell suspensions were stained with the following conjugated monoclonal antibodies: CD3 BV510, CD4 BV421, CD8 BV605, INF‐γ BV711, tumour necrosis factor‐α Alexa Fluor 700, interleukin (IL)‐13 antigen presenting cell, and IL‐2, measuring tumour necrosis factor‐alpha, interferon‐gamma, IL‐2, and IL‐13 as previously described 14 . Due to insufficient number of viable peripheral blood mononuclear cells, only B‐strains were used for analysis.…”

Section: Methodsmentioning

confidence: 99%

“…interferon-gamma, IL-2, and IL-13 as previously described. 14 Due to insufficient number of viable peripheral blood mononuclear cells, only B-strains were used for analysis. The same two B influenza antigens that were included in the vaccine were used for the cell stimulation and those were the Washington and Phuket strains.…”

Section: Key Notesmentioning

confidence: 99%

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Adequate immune responses to vaccines after chemotherapy for leukaemia diagnosed in childhood

Óskarsson,

Thors,

Vias

et al. 2023

Acta Paediatrica

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AimThe survival rate after treatment for childhood leukaemia has greatly improved, but could result in protracted immune deficiency. This study examined the immune status of children after chemotherapy and evaluated their responses to immunisation.MethodsSubjects who had completed their treatment for acute lymphoblastic leukaemia at The Children's Hospital Reykjavík, Iceland, during 2011–2020 had blood drawn and were then immunised for influenza in October 2021. Blood was drawn again 4 weeks later and their humoral and cellular responses were measured with a haemagglutination inhibition assay and lymphocyte stimulation test. Antibodies to other immunisations were also evaluated.ResultsWe studied 18 patients (10 male) who had completed their treatment at 3.7–20.3 years of age (mean 9.1), 11–84 months (mean 36.9) before enrolment. Conventional immunological evaluation did not reveal notable abnormalities. The responses to several childhood vaccinations, including the pneumococcal conjugate vaccination, were adequate in most patients. Humoral responses to the influenza vaccine confirmed adequate reactions in all but one patient. Considerable variations were observed in the lymphocyte stimulations tests.ConclusionMost patients reacted adequately to immunisation, especially against annual influenza and Streptococcus pneumoniae, reiterating the usefulness of vaccinations. The most appropriate timing for vaccination after treatment still needs to be determined.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Key Notesmentioning

confidence: 99%

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