Obesity indices and metabolic markers are related to hs-CRP and adiponectin levels in overweight and obese females

Sanip, Zulkefli; Ariffin, Farah Diana; Al-Tahami, Belqes Abdullah Mohammed; Sulaiman, Wan Azman Wan; Rasool, Aida Hanum Ghulam

doi:10.1016/j.orcp.2012.05.002

Cited by 29 publications

(22 citation statements)

References 26 publications

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“…It may be noted that recent advances in obesity research have shown increasing significance of acute phase reactant like C-reactive protein in inflammation related to obesity [32]. Further, advent of highly sensitive C-reactive protein (hsCRP) has made it possible for detection of even low amount of C-reactive protein [33]. Interestingly, significant association of hsCRP has been found with periodontal disease [34], therefore similar studies with hsCRP may prove to be quite noteworthy especially in the context of the fact that abdominal obesity and periodontal disease are both considered as a risk for cardiovascular diseases and hsCRP may provide the possible inflammatory link.…”

Section: Discussionmentioning

confidence: 99%

Serum interleukin-1β in subjects with abdominal obesity and periodontitis

Satpathy

Ravindra²,

Thakur

et al. 2015

Obesity Research & Clinical Practice

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Section: Discussionmentioning

confidence: 99%

Serum interleukin-1β in subjects with abdominal obesity and periodontitis

Satpathy

Ravindra²,

Thakur

et al. 2015

Obesity Research & Clinical Practice

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“…Even without pharmaceutical aid, significant decreases in CRP levels can be achieved as long as there are significant reductions in weight 39 . These findings, which have been supported by evidence that hs-CRP is positively associated with obesity 29,38 , suggest that hs-CRP levels are due in part to their production in adipose tissue. It can therefore be presumed that weight loss causes decreases in hs-CRP levels, as well.…”

mentioning

confidence: 66%

“…Increased hs-CRP levels as well as its positive correlation with obesity indices such as weight, BMI, WC, BF and VF have been previously reported in obese subjects 8,29 . Hs-CRP levels were also reported to be strongly correlated with the severity of obesity and central obesity 38 .…”

mentioning

confidence: 74%

Metabolic and Inflammatory Changes with Orlistat and Sibutramine Treatment in Obese Malaysian Subjects

et al. 2017

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Introduction: Obesity is associated with numerous health problems, particularly metabolic and cardiovascular complications. This study aimed to assess the effects that, nine months of pharmacological intervention with orlistat or sibutramine, on obese Malaysians' body weight and compositions, metabolic profiles and inflammatory marker.Methods: Seventy-six obese subjects were randomly placed into two groups. The first group received three daily 120 mg dosages of orlistat for nine months (n=39), and the second group received a once daily 10 or 15 mg dosage of sibutramine for nine months (n=37). Baseline measurements for weight, body mass index (BMI), waist circumference (WC), body fat percentage (BF), visceral fat (VF), adiponectin, fasting plasma glucose (FPG), fasting insulin, pancreatic B cell secretory capacity (HOMA%B), insulin sensitivity (HOMA%S), insulin resistance (HOMA-IR) and serum high sensitivity C-reactive protein (hs-CRP) were performed and repeated during the sixth and ninth months of treatment.Results: Twenty-four subjects completed the trial in both groups. For both groups, weight, BMI, WC, BF, VF, HOMA-IR and hs-CRP were significantly lower at the end of the nine month intervention.However, there were no significant differences between the two groups for these parameters with nine months treatment. There was a significant decrease in FPG in orlistat group; while fasting insulin and HOMA%B reduced in sibutramine group. For both groups, there were also significant increases in adiponectin levels and HOMA%S at the end of the nine month intervention. Conclusion:Nine months of treatment with orlistat and sibutramine not only reduced weight but also significantly improved BMI, WC, BF, VF, FPG, adiponectin, fasting insulin, HOMA%B, HOMA%S, HOMA-IR and hs-CRP. These improvements could prove useful in the reduction of metabolic and cardiovascular risks in obese subjects. (J Nippon Med Sch 2017; 84: 125 132)

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“…(2012) не выявили связи между базальными эндотелиальными колебани-ями микрососудов и индексами ожирения у женщин 34,9±7,9 лет в выборке с ИМТ 32,9±4,8 кг/м 2 , сравнимым с группой 1 в нашем исследовании [9]. Однако эти жен-щины были моложе и без СД.…”

Section: Discussionunclassified

“…Несмотря на определенные успехи в изучении потоковых свойств крови на уровне МЦР, основное внимание уделялось базальному кровотоку и вазомоциям. Полученные в целом ряде исследований данные противоречивы [5][6][7][8][9][10]. Однако большинство ав-торов считают, что базальная эндотелиальная активность у пациентов с СД2 ниже, чем у здоровых лиц [5,7,8,11].…”

Section: Diabetes Mellitus (N = 52); Group 2 Prediabetes (N = 16); Gunclassified

Associations of functional and biochemical parameters of endothelial dysfunction in postmenopausal women with a different state of carbohydrate metabolism

Ruyatkina¹,

Iskhakova²,

Ruyatkin³

2015

Diabetes mellitus

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Obesity indices and metabolic markers are related to hs-CRP and adiponectin levels in overweight and obese females

Cited by 29 publications

References 26 publications

Serum interleukin-1β in subjects with abdominal obesity and periodontitis

Serum interleukin-1β in subjects with abdominal obesity and periodontitis

Metabolic and Inflammatory Changes with Orlistat and Sibutramine Treatment in Obese Malaysian Subjects

Associations of functional and biochemical parameters of endothelial dysfunction in postmenopausal women with a different state of carbohydrate metabolism

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