Obesity is associated with an improved cancer-specific survival, but an increased rate of postoperative complications after surgery for renal cell carcinoma

Rogde, A J; Guðbrandsdottir, Gigja; Hjelle, Karin M.; Sand, Kristoffer; Bostad, Leif; Beisland, Christian

doi:10.3109/00365599.2012.678382

Cited by 33 publications

(22 citation statements)

References 31 publications

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“…For patients with organ-confined but not advanced RCC, being overweight improved their cancer specific survival [24]. Another study also reported that cancer-specific survival time, but not overall survival time, was notably prolonged for patients with increasing BMI (>30 kg/m 2 ) who had received radical nephrectomy [25]. …”

Section: Reviewmentioning

confidence: 99%

Metabolic syndrome and renal cell carcinoma

Zhang

Zhu

2014

World J Surg Onc

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BackgroundMetabolic syndrome (MS) is a cluster of metabolic abnormalities, which has been regarded as a pivotal risk factor for cardiovascular diseases. Recent studies focusing on the relationship between MS and cancer have recognized the significant role of MS on carcinogenesis. Likewise, growing evidence suggests that MS has a strong association with increased renal cell carcinoma (RCC) risk. This review outlines the link between MS and RCC, and some underlying mechanisms responsible for MS-associated RCC.Materials and methodsA National Center for Biotechnology Information PubMed search (http://www.pubmed.gov) was conducted using medical subject headings ‘metabolic syndrome’, ‘obesity’, ‘hypertension’, ‘diabetes’, ‘dyslipidemia’, and ‘renal cell carcinoma’.ResultsThis revealed that a variety of molecular mechanisms secondary to MS are involved in RCC formation, progression, and metastasis. A deeper understanding of these molecular mechanisms may provide some strategies for the prevention and treatment of RCC.ConclusionsIn summary, there is a large body of evidence regarding the link between MS and RCC, within which each component of MS is considered to have a close causal association with RCC.

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Section: Reviewmentioning

confidence: 99%

Metabolic syndrome and renal cell carcinoma

Zhang

Zhu

2014

World J Surg Onc

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“…However, the influence of these risk factors on prognosis and survival in patients with RCC has not been well studied, especially before the early 2000s. Recently, a number of studies have provided evidence that being overweight or obese, as measured by the body mass index, is a favorable prognostic factor in patients with RCC (4-11). A few studies have shown that smoking may increase the risk of mortality in patients with RCC (12-14), but there have been very few studies and inconsistent conclusions concerning blood pressure (15, 16).…”

Section: Introductionmentioning

confidence: 99%

Influence of Body Mass Index, Smoking, and Blood Pressure on Survival of Patients with Surgically-Treated, Low Stage Renal Cell Carcinoma: A 14-Year Retrospective Cohort Study

et al. 2013

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The association of body mass index, smoking, and blood pressure, which are related to the three well-established risk factors of renal cell carcinoma, and survival in patients with renal cell carcinoma is not much studied. Our objective was to evaluate this association. A cohort of 1,036 patients with low stage (pT1 and pT2) renal cell carcinoma who underwent radical or partial nephrectomy were enrolled. We retrospectively reviewed medical records and collected survival data. The body mass index, smoking status, and blood pressure at the time of surgery were recorded. Patients were grouped according to their obesity grade, smoking status, and hypertension stage. Survival analysis showed a significant decrease in overall (P = 0.001) and cancer-specific survival (P < 0.001) with being underweight, with no differences of smoking status or perioperative blood pressure. On multivariate analysis, perioperative blood pressure ≥ 160/100 mmHg (HR, 2.642; 95% CI, 1.221-5.720) and being underweight (HR, 4.320; 95% CI, 1.557-11.984) were independent predictors of overall and cancer-specific mortality, respectively. Therefore, it is concluded that being underweight and perioperative blood pressure ≥ 160/100 mmHg negatively affect cancer-specific and overall survival, respectively, while smoking status does not influence survivals in patients with renal cell carcinoma.

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“…Currently over one-third of the United States'population is obese [24]. There is a growing body of literature that supports the notion that there is a higher risk for preoperative complications including greater risk for wound infections, airway-related complications, deep vein thrombosis, and pulmonary embolus [6,[25][26][27][28][29][30][31]. Foley et al [32] was the first to describe the MI-TLIF using tubular retractors via a muscle splitting approach to decrease the amount of soft tissue injury.…”

Section: Discussionmentioning

confidence: 99%

The effect of obesity on patient-reported outcome measures after minimally invasive transforaminal lumbar interbody fusion

McAnany¹,

Overley²,

Andelman³

et al. 2015

Integr Obesity Diabetes

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Obesity is associated with an improved cancer-specific survival, but an increased rate of postoperative complications after surgery for renal cell carcinoma

Abstract: In this material, increasing BMI was associated with improved CSS for presumed radically treated patients. However, obese patients had a higher total rate of postoperative complications.

Cited by 33 publications

References 31 publications

Metabolic syndrome and renal cell carcinoma

Metabolic syndrome and renal cell carcinoma

Influence of Body Mass Index, Smoking, and Blood Pressure on Survival of Patients with Surgically-Treated, Low Stage Renal Cell Carcinoma: A 14-Year Retrospective Cohort Study

The effect of obesity on patient-reported outcome measures after minimally invasive transforaminal lumbar interbody fusion

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