Obesity, obstructive sleep apnoea and metabolic syndrome

Lam, W.K. Jacky; Mak, Judith C.W.; Ip, Mary S.M.

doi:10.1111/j.1440-1843.2011.02081.x

Cited by 157 publications

(126 citation statements)

References 153 publications

(156 reference statements)

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“…[1][2][3][4] ; Mercè Gasa, Ph.D. 1,2 ; Mercedes Mayos, Ph.D. [3][4][5] ; Ana Maria Fortuna-Gutierrez, M.D. 4,5 ; Josep Maria Montserrat, Ph.D. 4,6 ; Manuel Sánchez-de-la-Torre, Ph.D. 4,7 ; Antonia Barceló, Ph.D. 4,8 ; Ferran Barbé, Ph.D. 4,8 ; Núria Vilarrasa, Ph.D. 9,10 ; Carmen Monasterio, Ph.D.…”

Section: Impact Of Osa On Biological Markers In Morbid Obesity and Meunclassified

“…1,2 There is increasing evidence, mainly from studies in moderately obese sleep-referred patient cohorts, that obstructive sleep apnea (OSA) may impact negatively on MetS or some of its components, independent of the body mass index (BMI). 3 Furthermore, in a large cross-sectional study of non-selected morbidly obese patients with a high prevalence of MetS, 4 OSA was associated with a worse metabolic profi le independent of BMI, suggesting that OSA plays an important role in the pathogenesis of metabolic dysfunction, even in morbid obesity.…”

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confidence: 99%

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Impact of OSA on Biological Markers in Morbid Obesity and Metabolic Syndrome

Salord¹,

Gasa

Mayos³

et al. 2014

Journal of Clinical Sleep Medicine

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Section: Impact Of Osa On Biological Markers In Morbid Obesity and Meunclassified

mentioning

confidence: 99%

Impact of OSA on Biological Markers in Morbid Obesity and Metabolic Syndrome

Salord¹,

Gasa

Mayos³

et al. 2014

Journal of Clinical Sleep Medicine

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“…16 OSA is also associated with metabolic dysregulation, affecting glucose control and risk for diabetes. 17 Undiagnosed and untreated OSA is a significant burden on the healthcare system, with increased healthcare utilization seen in those with untreated OSA, 18 highlighting the importance of early and accurate diagnosis of this common disorder.…”

Section: Backg Roundmentioning

confidence: 99%

Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline

Kapur

Auckley

Chowdhuri

et al. 2017

Journal of Clinical Sleep Medicine

2,124

1,498

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Introduction: This guideline establishes clinical practice recommendations for the diagnosis of obstructive sleep apnea (OSA) in adults and is intended for use in conjunction with other American Academy of Sleep Medicine (AASM) guidelines on the evaluation and treatment of sleep-disordered breathing in adults. Methods: The AASM commissioned a task force of experts in sleep medicine. A systematic review was conducted to identify studies, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) process was used to assess the evidence. The task force developed recommendations and assigned strengths based on the quality of evidence, the balance of benefits and harms, patient values and preferences, and resource use. In addition, the task force adopted foundational recommendations from prior guidelines as "good practice statements", that establish the basis for appropriate and effective diagnosis of OSA. The AASM Board of Directors approved the final recommendations. Recommendations:The following recommendations are intended as a guide for clinicians diagnosing OSA in adults. Under GRADE, a STRONG recommendation is one that clinicians should follow under most circumstances. A WEAK recommendation reflects a lower degree of certainty regarding the outcome and appropriateness of the patient-care strategy for all patients. The ultimate judgment regarding propriety of any specific care must be made by the clinician in light of the individual circumstances presented by the patient, available diagnostic tools, accessible treatment options, and resources. Good Practice Statements:Diagnostic testing for OSA should be performed in conjunction with a comprehensive sleep evaluation and adequate follow-up. Polysomnography is the standard diagnostic test for the diagnosis of OSA in adult patients in whom there is a concern for OSA based on a comprehensive sleep evaluation. Recommendations:1. We recommend that clinical tools, questionnaires and prediction algorithms not be used to diagnose OSA in adults, in the absence of polysomnography or home sleep apnea testing. (STRONG) 2. We recommend that polysomnography, or home sleep apnea testing with a technically adequate device, be used for the diagnosis of OSA in uncomplicated adult patients presenting with signs and symptoms that indicate an increased risk of moderate to severe OSA. (STRONG) 3. We recommend that if a single home sleep apnea test is negative, inconclusive, or technically inadequate, polysomnography be performed for the diagnosis of OSA. (STRONG) 4. We recommend that polysomnography, rather than home sleep apnea testing, be used for the diagnosis of OSA in patients with significant cardiorespiratory disease, potential respiratory muscle weakness due to neuromuscular condition, awake hypoventilation or suspicion of sleep related hypoventilation, chronic opioid medication use, history of stroke or severe insomnia. (STRONG) 5. We suggest that, if clinically appropriate, a split-night diagnostic protocol, rather than a full-night diagnostic protoc...

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“…28 The past two decades have seen a growing recognition of the presence of various types of metabolic dysfunction in subjects with OSAHS, and the association of OSAHS and MS was highlighted as ''syndrome Z'' in the late 1990s. 11,13,30 Aims of the study…”

Section: Introductionmentioning

confidence: 99%

Prevalence of components of metabolic syndrome in pregnant women with obstructive sleep apnoea hypopnoea syndrome

2017

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Background: Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) related cardiovascular and metabolic risk factors such as hypertension, diabetes mellitus and dyslipidaemia which together are commonly known as metabolic syndrome (MS) is often overlooked in pregnancy. OSAHS is known to cause higher maternal morbidity and bad foetal outcome. Aim was to study the prevalence of components of MS among third trimester pregnant women with OSAHS.Methods: A total of 100 cases and 100 controls each amongst third trimester pregnant females admitted in the Department of Obstetrics and Gynecology at the Government Medical College, Kozhikode, Kerala, India were enrolled in the study. All subjects underwent a thorough clinical, anthropometric, obstetrical examination and biochemical tests such as complete blood count, blood sugar and lipid profile. The parameters were compared between cases and controls.Results: OSAHS positive pregnant women had a higher prevalence of elevated systolic (P=0.01) and diastolic (P=0.002) blood pressure, abnormal fasting (P<0.0001) and post prandial (P=0.02) blood sugar, abnormal cholesterol (P=0.006) and triglyceride levels (P<0.001), and abnormally low HDL levels (P<0.001).Conclusions: This study showed that metabolic syndrome was highly prevalent among OSAHS positive third trimester pregnancy (52%) versus OSAHS negative (8%) pregnant women.

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Obesity, obstructive sleep apnoea and metabolic syndrome

Cited by 157 publications

References 153 publications

Impact of OSA on Biological Markers in Morbid Obesity and Metabolic Syndrome

Impact of OSA on Biological Markers in Morbid Obesity and Metabolic Syndrome

Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline

Prevalence of components of metabolic syndrome in pregnant women with obstructive sleep apnoea hypopnoea syndrome

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