Object recognition testing: Rodent species, strains, housing conditions, and estrous cycle

Goethem, Nick P. van; Rutten, Kris; Staay, Franz Josef van der; Jans, L.A.W.; Akkerman, Sven; Steinbusch, Harry W.M.; Blokland, Arjan; Klooster, José van’t; Prickaerts, Jos

doi:10.1016/j.bbr.2012.03.023

Cited by 105 publications

(103 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over time, it has become a widely used tool for the assessment of memory functions in combination with pharmacological treatments [6][7][8][9][10] and brain lesions [11][12][13][14]. The ORT is mainly used for rodent experiments, most research is done with rats and mice but the task is also suitable for testing other rodent species [15]. It has also been successfully applied using larger animal species like dogs [16], pigs [17,18] and horses [19], making it a versatile tool suitable for inter-species comparisons.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Object recognition testing: Methodological considerations on exploration and discrimination measures

Akkerman

Blokland

Reneerkens

et al. 2012

Behavioural Brain Research

Self Cite

178

123

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

“…Differences exist in object and arena features like the size, shape and materials. Also, differences in animal strain, age, gender, and housing conditions have been reported to influence object recognition [15,[26][27][28][29]. Furthermore, different test protocols are being used.…”

Section: Introductionmentioning

confidence: 99%

Object recognition testing: Methodological considerations on exploration and discrimination measures

Akkerman

Blokland

Reneerkens

et al. 2012

Behavioural Brain Research

Self Cite

178

123

View full text Add to dashboard Cite

“…It has been documented in the literature that there are sex differences in the response of rodents in an object recognition memory task. Females with lower estrogen levels are similar to males and females with higher estrogen levels are better than males and females with low estrogen [28,32]. Thus, there appears to be a relationship between estrogen levels and behavior during an object recognition memory task.…”

Section: Discussionmentioning

confidence: 91%

“…It is well known that many strains of rats and mice can show diverse behavioral outcomes, which is thought to be due to their underlying genetic differences [28][29][30][31]. A study by Markowska and Savonenko demonstrated age-related decrements in Morris water maze behavior but an intervention such as caloric restriction only alleviated the deficit in the Fischer 344XBrown Norway strain not the parental strain [24].…”

Section: Discussionmentioning

confidence: 99%

Novel object recognition is not affected by age despite age-related brain changes

Aktoprak¹,

Dinc²,

Günay³

et al. 2013

WJNS

View full text Add to dashboard Cite

Age-related memory impairments show a progressive decline across lifespan. Studies have demonstrated equivocal results in biological and behavioral outcomes of aging. Thus, in the present study we examined the novel object recognition task at a delay period that has been shown to be impaired in aged rats of two different strains. Moreover, we used a strain of rats, Fisher 344XBrown Norway, which have published age-related biological changes in the brain. Young (10 months old) and aged (28 months old) rats were tested on a standard novel object recognition task with a 50 minutes delay period. The data showed that young and aged rats in the strain we used performed equally well on the novel object recognition task and that both young and old rats demonstrated a righthanded side preference for the novel object. Our data suggested that novel object recognition is not impaired in aged rats although both young and old rats have a demonstrated side preference. Thus, it may be that genetic differences across strains contribute to the equivocal results in behavior, and genetic variance likely influences the course of cognitive aging.

show abstract

“…Some studies reported that estrus cycle affect learning and memory, and emotionality (Frye et al, 2000;Marcondes et al, 2001;Pompili et al, 2010;van Goethem et al, 2012). Furthermore, a number of studies repoted that BPA inhibits the effect of estrogen which is an improvement in learning and memory, and the effects of BPA are dependent on endogenous estrogen (Xu et al, 2011;Inagaki et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats

et al. 2015

View full text Add to dashboard Cite

-Nonylphenol ethoxylate (NPE) is a non-ionic surfactant, that is degraded to short-chain NPE and 4-nonylphenol (NP) by bacteria in the environment. NP, one of the most common environmental endocrine disruptors, exhibits weak estrogen-like activity. In this study, we investigated whether oral administration of NP (at 0.5 and 5 mg/kg doses) affects spatial learning and memory, general activity, emotionality, and fear-motivated learning and memory in male and female Sprague-Dawley (SD) rats. SD rats of both sexes were evaluated using a battery of behavioral tests, including an appetite-motivated maze test (MAZE test) that was used to assess spatial learning and memory. In the MAZE test, the time required to reach the reward in male rats treated with 0.5 mg/kg NP group and female rats administered 5 mg/kg NP was significantly longer than that for control animals of the corresponding sex. In other behavioral tests, no significant differences were observed between the control group and either of the NP-treated groups of male rats. In female rats, inner and ambulation values for animals administered 0.5 mg/kg NP were significantly higher than those measured in control animals in open-field test, while the latency in the group treated with 5 mg/kg NP was significantly shorter compared to the control group in step-through passive avoidance test. This study indicates that oral administration of a low-dose of NP slightly impairs spatial learning and memory performance in male and female rats, and alters emotionality and fear-motivated learning and memory in female rats only.

show abstract

Object recognition testing: Rodent species, strains, housing conditions, and estrous cycle

Cited by 105 publications

References 64 publications

Object recognition testing: Methodological considerations on exploration and discrimination measures

Object recognition testing: Methodological considerations on exploration and discrimination measures

Novel object recognition is not affected by age despite age-related brain changes

Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats

Contact Info

Product

Resources

About