Objective and subjective treatment evaluation of scars using optical coherence tomography, sonography, photography, and standardised questionnaires

Reinholz, Markus; Schwaiger, Hannah; Poetschke, Julian; Epple, Andreas; Ruzicka, Thomas; Braunmühl, Tanja von; Gauglitz, Gerd G.

doi:10.1684/ejd.2016.2873

Cited by 21 publications

(23 citation statements)

References 33 publications

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“…Based on their study data, both applied objective measurement methods can be recommended as highly suitable for the therapeutic assessment of pathologic scars. For an overall therapeutic assessment, however, standardized questionnaires may be helpful by adding additional relevant parameters to the evaluation 33,48,49 because successful scar treatments also include the reduction of scar-associated symptoms such as pain, contractures, and pruritus. Established questionnaires such as the Patient and Observer Scar Assessment Scale or the Dermatology Life Quality Index cover important items of augmented scar formation and may therefore be applied for additional assessment of scar therapy.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Therapeutic Success of Keloids Treated With Cryotherapy and Intralesional Corticosteroids Using Noninvasive Objective Measures

Schwaiger

Reinholz

Poetschke

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Evaluating the Therapeutic Success of Keloids Treated With Cryotherapy and Intralesional Corticosteroids Using Noninvasive Objective Measures

Schwaiger

Reinholz

Poetschke

et al. 2018

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“…It has been indicated that this subjective component of the patient’s view of the scar is as important as objective aspect and it may be very influential in determining the patient’s quality of life (73, 74). Assessment of the scars is a frequent topic of discussion among clinicians because there is no generally accepted evaluation tool, although various ones have been proposed (75–77). None of these, however, seem suitable as a stand-alone tool, suggesting that combination of objective imaging tools and scar scales and questionnaires may be justified to achieve comprehensive documentation in everyday clinical practice (78).…”

Section: Scar Evaluationmentioning

confidence: 99%

Current Therapeutic Approach to Hypertrophic Scars

et al. 2017

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Abnormal scarring and its accompanying esthetic, functional, and psychological sequelae still pose significant challe nges. To date, there is no satisfactory prevention or treatment option for hypertrophic scars (HSs), which is mostly due to not completely comprehending the mechanisms underlying their formation. That is why the apprehension of regular and controlled physiological processes of scar formation is of utmost importance when facing hypertrophic scarring, its pathophysiology, prevention, and therapeutic approach. When treating HSs and choosing the best treatment and prevention modality, physicians can choose from a plethora of therapeutic options and many commercially available products, among which currently there is no efficient option that can successfully overcome impaired skin healing. This article reviews current therapeutic approach and emerging therapeutic strategies for the management of HSs, which should be individualized, based on an evaluation of the scar itself, patients’ expectations, and practical, evidence-based guidelines. Clinicians are encouraged to combine various prevention and treatment modalities where combination therapy that includes steroid injections, 5-fluorouracil, and pulsed-dye laser seems to be the most effective. On the other hand, the current therapeutic options are usually empirical and their results are unreliable and unpredictable. Therefore, there is an unmet need for an effective, targeted therapy and prevention, which would be based on an action or a modulation of a particular factor with clarified mechanism of action that has a beneficial effect on wound healing. As the extracellular matrix has a crucial role in cellular and extracellular events that lead to pathological scarring, targeting its components mostly by regulating bone morphogenetic proteins may throw up new therapeutic approach for reduction or prevention of HSs with functionally and cosmetically acceptable outcome.

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“…The effective rate of itching and pain symptoms is 72% and 56%, respectively, and the effective rate of no subjective symptoms was 96% and 84%, respectively. The results showed that the effectiveness of the two methods to evaluate the absence of subjective symptoms was higher than the effective rate of itching and pain symptoms, indicating that the presence or absence of subjective symptoms is also one of the indicators of the severity of keloids . However, a simple ultrasound assessment only measures changes in dermal thickness and does not take into account the patient's subjective perception.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of triamcinolone acetonide in the treatment of keloids by high‐frequency ultrasound

Cai

Lin

et al. 2019

Skin Research and Technology

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Background: Intralesional injection of triamcinolone acetonide is an effective method for treating keloids. It still lacks effective and objective evaluation methods. This study aimed to observe the efficacy of intralesional triamcinolone acetonide injections for the treatment of keloids and to explore the role of high-frequency ultrasound in the monitoring and evaluation of keloids therapy. Methods: Fifty-one patients with keloids were treated with triamcinolone acetonide, once a week for 4 weeks. Lesions were detected, recorded, and evaluated using digital photography and high-frequency ultrasound before and after treatment. Results: High-frequency ultrasound showed the depth of drug injection. After the last treatment, an average decrease in dermal tissue layer thickness of 39.0% is compared with before treatment. In addition, there are significant differences in the effectiveness of clinical assessments and ultrasound assessments of keloids with or without subjective symptoms. Conclusion: The observed results confirmed that intralesional injections of triamcinolone acetonide can effectively treat keloids. High-frequency ultrasound can be used as a therapeutic monitoring and therapeutic evaluation tool for intralesional injections of triamcinolone acetonide.

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Objective and subjective treatment evaluation of scars using optical coherence tomography, sonography, photography, and standardised questionnaires

Cited by 21 publications

References 33 publications

Evaluating the Therapeutic Success of Keloids Treated With Cryotherapy and Intralesional Corticosteroids Using Noninvasive Objective Measures

Evaluating the Therapeutic Success of Keloids Treated With Cryotherapy and Intralesional Corticosteroids Using Noninvasive Objective Measures

Current Therapeutic Approach to Hypertrophic Scars

Evaluation of the efficacy of triamcinolone acetonide in the treatment of keloids by high‐frequency ultrasound

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