Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis

Mohamed, Abdalla Z.; Andersen, Thu; Radović, Sanja; Fante, Peter Del; Kwiatek, Richard; Calhoun, Vince D.; Bhuta, Sandeep; Hermens, Daniel F.; Lagopoulos, Jim; Shan, Zack

doi:10.1016/j.smrv.2023.101771

Cited by 11 publications

(3 citation statements)

References 99 publications

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“…Positive studies: non-restorative sleep, restlessness, insomnia, sleep apnea more common in people with ME/CFS (187), although formal sleep laboratory studies have produced inconsistent results (188,189). Meta-analysis of studies of ˜1300 adults and adolescents finds longer sleep latency, reduced sleep efficiency, increased longer REM latency, longer bedtime, and altered sleep microstructure (190).…”

Section: Sleep Disordersmentioning

confidence: 98%

ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

2023

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Some patients remain unwell for months after “recovering” from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms that greatly interfere with their ability to function and that can leave some people housebound and disabled. The illness (Long COVID) is similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well as to persisting illnesses that can follow a wide variety of other infectious agents and following major traumatic injury. Together, these illnesses are projected to cost the U.S. trillions of dollars. In this review, we first compare the symptoms of ME/CFS and Long COVID, noting the considerable similarities and the few differences. We then compare in extensive detail the underlying pathophysiology of these two conditions, focusing on abnormalities of the central and autonomic nervous system, lungs, heart, vasculature, immune system, gut microbiome, energy metabolism and redox balance. This comparison highlights how strong the evidence is for each abnormality, in each illness, and helps to set priorities for future investigation. The review provides a current road map to the extensive literature on the underlying biology of both illnesses.

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Section: Sleep Disordersmentioning

confidence: 98%

ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

2023

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“…The results of a meta-analysis demonstrate that sleep is altered in CFS, with changes seeming to differ between adolescents and adults, suggesting sympathetic and parasympathetic nervous system alterations in ME/CFS [ 153 ].…”

Section: Resultsmentioning

confidence: 99%

Nutrition and Chronobiology as Key Components of Multidisciplinary Therapeutic Interventions for Fibromyalgia and Associated Chronic Fatigue Syndrome: A Narrative and Critical Review

Carrasco-Querol,

Cabricano-Canga,

Bueno Hernández

et al. 2024

Nutrients

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Fibromyalgia (FM) is often accompanied by chronic fatigue syndrome (CFS). It is a poorly understood disorder that mainly affects women and leads to chronic pain, fatigue, and insomnia, among other symptoms, which decrease quality of life. Due to the inefficiency of current pharmacological treatments, increasing interest is being directed towards non-pharmacological multicomponent therapies. However, nutrition and chronobiology are often overlooked when developing multicomponent therapies. This narrative and critical review explore the relevance of nutritional and chronobiological strategies in the therapeutic management of FM and the often-associated CFS. Reviewed literature offers scientific evidence for the association of dietary habits, nutrient levels, body composition, gut microbiota imbalance, chronobiological alterations, and their interrelation with the development and severity of symptoms. This review highlights the key role of nutrition and chronobiology as relevant and indispensable components in a multidisciplinary approach to FM and CFS.

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“…These include accelerometers to monitor activity levels [247,[264][265][266][267][268][269][270], cardiopulmonary exercise testing to characterize exercise performance [269,271], and the hand grip strength test to measure muscle fatigability [272,273]. Objective measures of sleep defects (reviewed in [274]) and cognitive impairment (reviewed in [275]) have also been assessed in ME/CFS patients.…”

Section: Objective Outcome Measuresmentioning

confidence: 99%

Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives

Seton,

Espejo-Oltra,

Giménez-Orenga

et al. 2024

JCM

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, debilitating, and multi-faceted illness. Heterogenous onset and clinical presentation with additional comorbidities make it difficult to diagnose, characterize, and successfully treat. Current treatment guidelines focus on symptom management, but with no clear target or causative mechanism, remission rates are low, and fewer than 5% of patients return to their pre-morbid activity levels. Therefore, there is an urgent need to undertake robust clinical trials to identify effective treatments. This review synthesizes insights from clinical trials exploring pharmacological interventions and dietary supplements targeting immunological, metabolic, gastrointestinal, neurological, and neuroendocrine dysfunction in ME/CFS patients which require further exploration. Additionally, the trialling of alternative interventions in ME/CFS based on reported efficacy in the treatment of illnesses with overlapping symptomology is also discussed. Finally, we provide important considerations and make recommendations, focusing on outcome measures, to ensure the execution of future high-quality clinical trials to establish clinical efficacy of evidence-based interventions that are needed for adoption in clinical practice.

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Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis

Cited by 11 publications

References 99 publications

ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

Nutrition and Chronobiology as Key Components of Multidisciplinary Therapeutic Interventions for Fibromyalgia and Associated Chronic Fatigue Syndrome: A Narrative and Critical Review

Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives

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