Objectively Measured Time Spent Sedentary Is Associated With Insulin Resistance Independent of Overall and Central Body Fat in 9- to 10-Year-Old Portuguese Children

Sardinha, Luís B.; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Quitério, Ana; Ornelas, Rui; Fröberg, Karsten; Riddoch, Chris; Ekelund, Ulf

doi:10.2337/dc07-1286

Cited by 160 publications

(173 citation statements)

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“…As concerns the association between objectively measured sedentary time and IR, our results are in disagreement with those reported for 9 to 10-yr-old Portuguese children [13] and adults [20], while are in the same line with those detected in adults with a family history of type 2 diabetes [21]. Differences between studies are likely The positive association observed between TV viewing time and IR risk could be explained by a number of mechanisms.…”

Section: Discussioncontrasting

confidence: 57%

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Sedentarism and Physical Inactivity Patterns Correlated with HOMA-IR in European Adolescents, the Helena Study

Aikaterini¹,

Kondaki²,

Kurlaba³

et al. 2017

J Nutr Food Sci

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Objective: The aim of the present study was to examine the independent association between time spent on sedentary activity, either objectively measured or self-reported and IR proxy measures in European adolescents. Methods:A subset (n=1,097) of a large multicentre European study in adolescents (HELENA-CSS study) was used in the present study. Homeostasis model assessment (HOMA)-IR was calculated. Serum concentrations of glucose (GF) and insulin (IF) were measured after an overnight fast. The HOMA-IR was calculated as IF (µlU/mL) × GF (mmol/l)/22.5 (to convert IF values in µlU/mL to pmol/l multiply by 6.945) sedentary time and the time spent on moderate-to-vigorous physical activity (MVPA) was objectively measured by using accelerometers. Moreover, the daily minutes spent on sedentary activities were recorded through a self-report sedentary behaviour questionnaire.Results: Univariate analyses showed that HOMA-IR levels were significantly higher among adolescents watching TV ≥ 2h/day (1.87 (C.I.1.31, 2.66)) compared to the rest of adolescents (2.02 (1.44, 2.82), p=0.011). Moreover, the objectively measured MVPA was inversely correlated to HOMA-IR (rho=-0.117, p=0.023). Multilevel linear regression analysis revealed that adolescents watching TV ≥ 2 h/day had significantly higher HOMA-IR even after controlling for gender, age, total energy intake, total fat intake, simple carbohydrate intake and pubertal stage (p=0.007). Further adjustment for MVPA, showed that TV viewing time remained significantly related to the IR (p=0.002). In this model, MVPA was also inversely associated with HOMA-IR levels (p=0.001). Finally, further controlling for waist circumference showed that adolescents exceeding the limit of 2 h/day watching TV continued to have higher HOMA-IR levels (p=0.002). Stratified analysis by BMI status, revealed that TV viewing time is independently associated with HOMA-IR only among normal weight adolescents, while MVPA was inversely associated with IR in both overweight/ obese and normal weight adolescents. Conclusions:The results of the present study indicate that time spent watching TV and at MVPA is related to IR independent of central fat mass and total energy intake in normal weight European adolescents, while MVPA seems to protect adolescents from developing IR even among overweight/obese adolescents. Therefore, intervention programmes aiming at reducing sedentary behaviours and increasing overall moderate-intensity activities should be implemented.

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Section: Discussioncontrasting

confidence: 57%

“…Moreover, limited data are available regarding the independent associations between different subcomponents of PA (i.e. time spent sedentary, at light-intensity activity and at moderateand vigorous intensity physical activity (MVPA) and self-reported TV viewing) and IR, especially among children/adolescents [13,20,21].…”

Section: Introductionmentioning

confidence: 99%

Sedentarism and Physical Inactivity Patterns Correlated with HOMA-IR in European Adolescents, the Helena Study

Aikaterini¹,

Kondaki²,

Kurlaba³

et al. 2017

J Nutr Food Sci

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“…1 study found a favourable association between sporadic MVPA and systolic BP (Holman et al 2011) Poitras et al Leary et al 2008;Colley et al 2012;Hearst et al 2012;Mendoza et al 2012;Carson et al 2013 Mendoza et al 2012;Carson et al 2013;Chaput et al 2013;Hjorth et al 2014a;Stabelini Neto et al 2014) MPA: null association (1/1 studies; Stabelini Neto et al 2014) LPA: null associations (2/2 studies; Carson et al 2013;Stabelini Neto et al 2014 Andersen et al 2006;Rizzo et al 2008;Sardinha et al 2008;Owen et al 2010;Hjorth et al 2014a), or null (1/6 studies; Jimenez-Pavon et al …”

Section: Mvpamentioning

confidence: 99%

“…n Includes 47 cross-sectional studies (Brage et al 2004a(Brage et al , 2004bGutin et al 2005b;Wennlof et al 2005;Andersen et al 2006;Ekelund et al 2006Ekelund et al , 2009Hurtig-Wennlof et al 2007;Quiros-Tejeira et al 2007;Rizzo et al 2007Rizzo et al , 2008Butte et al 2007b;Ruiz et al 2007;Leary et al 2008;Mark and Janssen 2008;Sardinha et al 2008;Sakuragi et al 2009;Schofield et al 2009;LeBlanc and Janssen 2010;Nguyen et al 2010;Owen et al 2010;Carson and Janssen 2011;Holman et al 2011;Moreira et al 2011;Colley et al 2012;Hay et al 2012;Hearst et al 2012;Henderson et al 2012;Jimenez-Pavon et al 2012, 2013b, 2013cMartinez-Gomez et al 2012;Mota et al 2012;Mendoza et al 2012;Barreira et al 2013;Carson et al 2013;Chaput et al 2013;Janssen et al 2013;Lamotte et al 2013;Knowles et al 2013;Loprinzi et al 2013;Rey-Lopez et al 2013;…”

Section: Mpamentioning

confidence: 99%

“…HOMA: associations were favourable (1/2 studies; Rizzo et al 2008 Rizzo et al 2008) LPA: associations were favourable (1/5 studies; Butte et al 2007b) or null (4/5 studies; Rizzo et al 2008;Sardinha et al 2008;Carson et al 2013;Jimenez-Pavon et al 2013c) Fasting glucose: Total PA: associations were favourable (3/7 studies; Andersen et al 2006;Ekelund et al 2006;Rizzo et al 2008), null (3/7 studies; Brage et al 2004a;Chaput et al 2013;Jimenez-Pavon et al 2013c), or mixed (favourable and null; 1/7 studies; Hurtig-Wennlof et al 2007) VPA: associations were favourable (1/3 studies; Rizzo et al 2008) or null (2/3 studies; Jimenez-Pavon et al 2013c;Stabelini Neto et al 2014) MVPA: associations were favourable (1/8 studies; Rizzo et al 2008), null (6/8 studies; Owen et al 2010;Mendoza et al 2012;Carson et al 2013;Chaput et al 2013;Jimenez-Pavon et al 2013c;Stabelini Neto et al 2014) or mixed (favourable and null; 1/8 studies; Hurtig-Wennlof et al 2007). 1/1 studies found no association between MVPA and 2-h plasma glucose (Carson et al 2013) Rizzo et al 2008;Carson et al 2013;Jimenez-Pavon et al 2013c;Stabelini Neto et al 2014).…”

Section: Mpamentioning

confidence: 99%

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Systematic review of the relationships between objectively measured physical activity and health indicators in school-aged children and youth

Poitras

Gray

Borghese

et al. 2016

Appl. Physiol. Nutr. Metab.

1,557

1,229

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Moderate-to-vigorous physical activity (MVPA) is essential for disease prevention and health promotion. Emerging evidence suggests other intensities of physical activity (PA), including light-intensity activity (LPA), may also be important, but there has been no rigorous evaluation of the evidence. The purpose of this systematic review was to examine the relationships between objectively measured PA (total and all intensities) and health indicators in school-aged children and youth. Online databases were searched for peer-reviewed studies that met the a priori inclusion criteria: population (apparently healthy, aged 5-17 years), intervention/exposure/comparator (volumes, durations, frequencies, intensities, and patterns of objectively measured PA), and outcome (body composition, cardiometabolic biomarkers, physical fitness, behavioural conduct/pro-social behaviour, cognition/academic achievement, quality of life/well-being, harms, bone health, motor skill development, psychological distress, self-esteem). Heterogeneity among studies precluded meta-analyses; narrative synthesis was conducted. A total of 162 studies were included (204 171 participants from 31 countries). Overall, total PA was favourably associated with physical, psychological/social, and cognitive health indicators. Relationships were more consistent and robust for higher (e.g., MVPA) versus lower (e.g., LPA) intensity PA. All patterns of activity (sporadic, bouts, continuous) provided benefit. LPA was favourably associated with cardiometabolic biomarkers; data were scarce for other outcomes. These findings continue to support the importance of at least 60 min/day of MVPA for disease prevention and health promotion in children and youth, but also highlight the potential benefits of LPA and total PA. All intensities of PA should be considered in future work aimed at better elucidating the health benefits of PA in children and youth.Key words: physical activity, body composition, cardiometabolic biomarkers, fitness, behavioural conduct, bone health, academic achievement, quality of life, well-being, children.Résumé : L'activité physique d'intensité moyenne à vigoureuse (« MVPA ») est essentielle à la prévention des maladies et à la promotion de la santé. D'après de récentes données, l'activité physique (« PA ») pratiquée à d'autres intensités telles que légères (« LPA ») s'avère aussi importante, mais il n'y a pas d'évaluation rigoureuse de ces faits. Cette analyse documentaire systématique a pour objectif d'examiner la relation entre l'activité physique mesurée objectivement (totale et à chacune des intensités) et des indicateurs de la santé chez des enfants et des jeunes d'âge scolaire. On a cherché dans des bases de données en ligne pour identifier des études révisées par des pairs et présentant a priori les critères d'inclusion suivants : population (apparemment en santé, sujets âgés de 5 à 17 ans), intervention/exposition/comparateur (volume, durée, fréquence, intensité et types de mesure objective de PA) et le résultat (composition c...

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Moderate to Vigorous Physical Activity and Sedentary Time and Cardiometabolic Risk Factors in Children and Adolescents

Ekelund¹

2012

JAMA

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996

840

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Objectively Measured Time Spent Sedentary Is Associated With Insulin Resistance Independent of Overall and Central Body Fat in 9- to 10-Year-Old Portuguese Children

Cited by 160 publications

References 54 publications

Sedentarism and Physical Inactivity Patterns Correlated with HOMA-IR in European Adolescents, the Helena Study

Sedentarism and Physical Inactivity Patterns Correlated with HOMA-IR in European Adolescents, the Helena Study

Systematic review of the relationships between objectively measured physical activity and health indicators in school-aged children and youth

Moderate to Vigorous Physical Activity and Sedentary Time and Cardiometabolic Risk Factors in Children and Adolescents

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