Observations on Cobalt Polycythemia. I. Studies on the Peripheral Blood of Rats.

Stanley, Allan J.; Hopps, Howard C.; Hellbaum, Arthur A.

doi:10.3181/00379727-61-15249

Cited by 12 publications

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“…The erythropoiesis stimulating effect of cobalt has been known for many years, starting with scattered observations in patients with cobalt intoxication and animal experiments (Waltner & Waltner, 1929;Orten et al, 1933;Sutter, 1934;Stanley et al, 1946;Gardner, 1953;Schirrmacher, 1967). That the mechanism of action was mediated via the production of erythropoietin was first definitely shown by Goldwasser et a1 (1957,1958) and confirmed by Davis (1958) and Brown & Meineke (1958).…”

Section: Discussionmentioning

confidence: 99%

A Comparison of the Cobalt, Methylene Blue, Zinc, Arsenite and Amino Triazole Effect on Erythropoietin Production

1973

Br J Haematol

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The possible mechanisms of action of cobalt in stimulating erythropoietin production are considered.It is demonstrated that although arsenite shares some ofits biochemical effects with cobalt, it does not stimulate the production of erythropoietin. It has been claimed previously that methylene blue could prevent the development of erythrocytosis after cobalt. In the present series of experiments, however, methylene blue did not affect the production of erythropoietin after injection of cobalt to rabbits.

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Section: Discussionmentioning

confidence: 99%

A Comparison of the Cobalt, Methylene Blue, Zinc, Arsenite and Amino Triazole Effect on Erythropoietin Production

1973

Br J Haematol

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“…Untersuchungen des Blut-hzw. Erythrozytenvolumens haben daruber hinaus den absolu ten Charakter der Polyzythamie gezeigt (ORTEN et al 1933, DAVIS 1940, STANLEY, HOPPS und HELLBAUM 1946, GOODMAN 1947, BERLIN 195 1, FISHER 1959.…”

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“…Untersuchunyen in vitro uber den hemmenden Einfluss von Co auf Enzyme, die mit der GeTrebsatmung im Zusammenhang stehen (LEVY, LEVISOX und SCH.\DE 1950), beruhren unmittelbar das Problem einer histotoxischen Hypoxie des Geivebes als Ursache der erhohten Erythropoiese. Lebhaft wird die Frage von c b e rtragersubstanzen (Erythropoietinen), die unter Go-Wirkung freigesetzt rverden sollen, diskutiert (GOLDWASSER et al 1957, JACOBSON et al 1959a, b, BROWN und MEINEKE 1958 Die Hb-Konzentration rnit einem Endwert von 20 g yo liegt etwas unter den von anderen Autoren fur Ratten angegebenen Werten (ORTEN 1936, STANLEY et al 1946, CRAFTS 1952 (COPP und GREENBERG 1941, BERLIN 1950, CUTHBERTSON et al 1950, CARLBERGER 1961 (GOLDWASSER et al 1957(GOLDWASSER et al , 1958 Es sei schliesslich noch erwahnt, dass Co nicht die 0,-Kapazitat des arteriellen Blutes, etwa durch Methamoglobinbildung, herabzusetzen scheint (BUCCIERO und ORTEN 1949).…”

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Der Einfluss von Cobalt auf die Erythropoiese der Ratte

Tribukait

1963

Acta Physiologica Scandinavica

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Tribukait, B. Der Einfluss von Cobalt auf die Erythropoiese der Ratte. Acta physiol. scand. 1963. 58. 101–110. — The development of polycythemia in rats, treated with cobalt, was studied. Cobalt was injected intraperitoneally 6 times a week in increasing doses of 0.4, 0.6 and 0.8 mg/100 g body weight during 21, 22 and 45 days respectively. The total amount of hemoglobin, hemoglobin concentration, hematocrite, reticulocytes and blood volume were determined. Hemin, tagged in vivo with C14‐2‐glycine, was isolated from 0.1–0.2 ml blood samples and the specific activity was measured. The hemoglobin concentration, hematocrite and reticulocytes increased significantly during treatment with 0.4 mg cobalt, but the total hemoglobin was unchanged. There were no signs of hemolysis as evaluated from the specific hemin activity. During treatment with 0.6 and 0.8 mg cobalt the relative blood values increased further, and also the total hemoglobin increased. The hemoglobin concentration reached values of 20 g/100 ml of blood and the total hemoglobin increased from 2 to 3 g. The blood volume was unchanged. The reticulocytes reached a maximum value after about 40 days treatment and thereafter decreased to normal concentrations despite the increasing total hemoglobin. The degree of this polycythemia was similar to that one developed at an altitude of about 4000 m.

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“…Orten, Underhill, Mugrage and Lewis (1932), Orten (1936) and Stanley, Hopps and Hellbaum (1946), studied its effect on rats, Frost, Elvehjem and Hart (1941) on dogs, and Davis, McCullough and Rigdon (1945) on ducks. Cartwright (1947) gave a comprehensive review of the experimental work.…”

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confidence: 99%