Observations on multiple sperm granulomas in the rat epididymis following vasectomy

McGinn, J.S.; Sim, Iain; Bennett, N.K.; McDonald, Stuart W.

doi:10.1002/(sici)1098-2353(2000)13:3<185::aid-ca5>3.0.co;2-0

Cited by 21 publications

(14 citation statements)

References 7 publications

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“…Sperm granulomas also develop following vasectomy or occlusion of the vas deferens. Serial sectioning of a series of vasectomy-induced sperm granulomas showed that they were exclusively located within the interstitium and that most had lost any connection between the epididymal duct and the sperm granuloma (McGinn et al 2000). Synonyms: vasculitis, arteritis, perivascular inflammation, periarteritis, polyarteritis nodosa Pathogenesis: generally a feature of spontaneous, agerelated, systemic ''polyarteritis nodosa,'' which is a progressive degenerative lesion of the walls of small arterioles.…”

Section: Sperm Granuloma (Figures 121-123): Efferent Ducts Epididymismentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Creasy

Bube

Rijk³

et al. 2012

Toxicol Pathol

207

198

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the male reproductive system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the Internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the male reproductive system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Sperm Granuloma (Figures 121-123): Efferent Ducts Epididymismentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Creasy

Bube

Rijk³

et al. 2012

Toxicol Pathol

207

198

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“…Type 2 microcanals as a protective device to prevent extravasations of spermatozoa entering through the weak patches in the epithelium Spermatozoa can evoke an autoimmune response if they are extravasated (Nashan et al 1990, Flickinger et al 1995 as seen after vasectomy (McDonald 2000, McGinn et al 2000, and can result in provocation of an autoimmune response of extravasated sperm granuloma formation. Autoimmune response to sperm antigens is an established fact, and is the basis for infertility in men undergoing vasectomy (Alexander 1975, Alexander & Anderson 1979, Rose & Lucas 1979, Tung & Menge 1985, Flickinger et al 1986.…”

Section: Development Of Type 1 Microcanalmentioning

confidence: 99%

Microcanalization in the epididymis to overcome ductal obstruction caused by chronic exposure to chromium – a study in the mature bonnet monkey (Macaca radiata Geoffroy)

Aruldhas¹,

Subramanian²,

Sekhar³

et al. 2004

Reproduction

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In order to apprehend the toxic effects of chromium, an occupational/environmental pollutant, on the epididymis, adult bonnet monkeys were exposed to chromium (VI) in their drinking water at concentrations of 100, 200 and 400 p.p.m. for a chronic period of 180 days. At the end of the experimental period, testicles and segments of epididymis from control and treated monkeys were subjected to light microscopic (resin-embedded semi-thin sections) and transmission electron microscopic analyses. Among the various changes undergone by the epididymal epithelium, the present paper describes the origin of two different kinds of microcanals, probably caused by ductal obstruction. The first type of microcanal, which appears to provide passage for spermatozoa to bypass the obstructed main duct, is comparable with the one already reported in carbendazimtreated efferent ductules of the rat. The second type of microcanal, which is novel, consisted of a lumen in the epithelium enclosed by four to five cells, which are either modified basal cells, principal cells or a hitherto unknown cell type. This novel type of microcanal is suggested to be a device to entrap the spermatozoa which reach the core of the epithelium and may be a mechanism to prevent extravasation of sperm so as to avoid an autoimmune response of spermatic granuloma formation. Thus, the present study has shown that chronic exposure to chromium (VI) through drinking water can produce pathological manifestations in the epididymal epithelium but the epididymis, being a versatile organ, is capable of overcoming such adverse situations through novel devices.

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“…In a survey on the effects of chronic vasectomy in laboratory animals (hamster, rat, and monkey), Bedford [7] observed rapid formation of sperm granulomas in nearly all cases, either at the site of ligation on the vas deferens or in the cauda epididymidis. In the vasectomized rats, leakage and granuloma formation invariably occur about 2 weeks after vasectomy, either at the vasectomy site or in the tail of the epididymis [31,32,46].…”

Section: Introductionmentioning

confidence: 99%

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

et al. 2011

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The present study was undertaken to clarify changes in secretions of FSH, LH, inhibin and testosterone, and sperm motility after bilateral vasectomy in adult male rats. Bilateral vasectomy was created surgically (treated group) and intact rats were used as control (control group). On days 3,5,7,14,30, 60, and 90 after surgery, plasma concentrations of FSH, LH, inhibin, and testosterone were measured by radioimmunoassay, and sperm motility characteristics were measured by computer-assisted sperm analysis (CASA). The results show that weights of epididymides significantly increased in vasectomized rats as compared to control rats. Histologically, damage to spermatogenesis was observed in vasectomized rats. Multinucleated giant cells were observed in the lumen of some seminiferous tubules, and there were degenerative spermatids in the epididymides of vasectomized rats. Plasma levels of LH, FSH, and testosterone only decreased on day 3 after vasectomy; however, plasma levels of ir-inhibin significantly increased on day 3 after vasectomy. In addition, the sperm motility parameters, straight-line velocity, curvilinear velocity, deviation of the sperm head from the mean trajectory and the maximum amplitude of lateral head displacement were decreased from day 60 after vasectomy. These results suggest that vasectomy reduces sperm motility starting from day 60 after vasectomy, and early bilateral vasectomy does not strongly affect the endocrine function of the testis, though it may result in damage to spermatogenesis in vasectomized rats.

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Observations on multiple sperm granulomas in the rat epididymis following vasectomy

Cited by 21 publications

References 7 publications

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Microcanalization in the epididymis to overcome ductal obstruction caused by chronic exposure to chromium – a study in the mature bonnet monkey (Macaca radiata Geoffroy)

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

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