Observations on the HLA‐A2403 specificity

Street, J.; Hammond, Laura; Downing, Jonathan; Thompson, John; Darke, C.

doi:10.1034/j.1399-0039.2003.00050.x

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…A2403ϫ3, short A24 with most A3 and A9 reactive [26] A*2610 A26 A10 ------A26 short A26, A10var A*2611N not expressed Null ------NT A*2612 A26 ---1 A26 (100) b --A26 A*2613 A26 -------A10 NN: A26 A*2614 A26 -------A26 (Continued) …”

Section: International Cell Exchange Uclamentioning

confidence: 96%

HLA dictionary 2004: Summary of HLA-A, -B, -C, -DRB1/3/4/5, -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens

Schreuder¹,

Hurley

Marsh³

et al. 2005

Human Immunology

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This report presents serologic equivalents of human leukocyte antigen (HLA)-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, and -DQB1 alleles. The dictionary is an update of the one published in 2001. The data summarize equivalents obtained by the World Health Organization (WHO) Nomenclature Committee for Factors of the HLA System, the International Cell Exchange (UCLA), the National Marrow Donor Program, recent publications, and individual laboratories. This latest update of the dictionary is enhanced by the inclusion of results from studies performed during the 13th International Histocompatibility Workshop and from neural network analyses. A summary of the data as recommended serologic equivalents is presented as expert assigned types. The tables include remarks for alleles, which are or may be expressed as antigens with serologic reaction patterns that differ from the well-established HLA specificities. The equivalents provided will be useful in guiding searches for unrelated hematopoietic stem cell donors in which patients and/or potential donors are typed by either serology or DNA-based methods. The serological-DNA equivalent dictionary will also aid in typing and matching procedures for organ transplant programs whose waiting lists of potential donors and recipients are comprised of mixtures of serologic and DNA-based typings. The tables with HLA equivalents and a questionnaire for submission of serologic reaction patterns for poorly identified allelic products will be made available through the World Marrow Donor Association Web page (www.worldmarrow.org).

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Section: International Cell Exchange Uclamentioning

confidence: 96%

HLA dictionary 2004: Summary of HLA-A, -B, -C, -DRB1/3/4/5, -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens

Schreuder¹,

Hurley

Marsh³

et al. 2005

Human Immunology

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“…For example, the HLA-A alleles assigned to the A2403 specificity: HLA-A * 2403/2410/2433 were differentiated from HLA-A alleles assigned to the A24 specificity by primer mixture 6 ( Table 3) (see also Street et al, 2003).…”

Section: Differentiation Of Hla Split Specificitiesmentioning

confidence: 99%

Five-Locus HLA Typing of Hematopoietic Stem Cell Donor Volunteers Using PCR Sequence Specific Primers

Downing

Guttridge²,

Thompson³

et al. 2004

Genetic Testing

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We have developed a strategy for five-locus human leukocyte antigen (HLA) typing of hematopoeitic stem cell (HSC) donors using the polymerase chain reaction with sequence-specific primers (PCR-SSP). The PCR-SSP method is robust, reproducible, and accurate. New PCR-SSP mixtures can be added as required and all reactions are carried out under the same conditions, which can easily be applied to the typing of other loci, e.g., ABO blood groups. Initially, 127 PCR-SSP reactions were used to detect simultaneously HLA-A, -B, -C, -DRB1/3/4/5, and DQB1 alleles, differentiated generally to the level of the first two digits of the allele name, essentially equivalent to the serological split specificity. Approximately 40% of subjects were tested against a further 29 HLA-A, -B SSP mixtures to exclude rare alleles and unambiguously assign a two-digit HLA allele family. This gave an overall typing resolution equivalent to or greater than the split specificity level and covered all HLA-A, -B, -C, -DRBland DQB1 alleles listed in the WHO's Nomenclature for Factors of the HLA System, 2000. The Welsh Bone Marrow Donor Registry has used this strategy to HLA type over 35,000 HSC donors over 9 years. Comprehensive and accurate five-locus HLA typing allows confident and rapid identification of potential matched HSC donors for patients requiring stem cell transplantation generally without the need for typing additional loci. This allows resources to be focused directly on allele level typing of DRB1 and other loci. This strategy decreases overall donor work-up time, which is a major benefit to patients.

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“…Inspection of HLA‐A9 epitopes (2, 3) indicated that the A*2312 product should react serologically as a normal HLA‐A23.…”

Section: Detection Human Leukocyte Antigen (Hla)‐a*2312 By Polymerasementioning

confidence: 99%

HLA‐A*2312–a novel allele found during testing for the UK NEQAS for H&I DNA HLA‐typing scheme

et al. 2006

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Observations on the HLA‐A2403 specificity

Cited by 6 publications

References 17 publications

HLA dictionary 2004: Summary of HLA-A, -B, -C, -DRB1/3/4/5, -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens

HLA dictionary 2004: Summary of HLA-A, -B, -C, -DRB1/3/4/5, -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens

Five-Locus HLA Typing of Hematopoietic Stem Cell Donor Volunteers Using PCR Sequence Specific Primers

HLA‐A*2312–a novel allele found during testing for the UK NEQAS for H&I DNA HLA‐typing scheme

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