Observations on the Micelle Formation of 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl Ketone Hydrochloride (SK&amp;F 33 134-A) by NMR Spectroscopy

Warren, Richard; Stedman, R. J.; Shami, Elie G.; Rattie, Elisabeth S.; Ravin, Louis J.

doi:10.1002/jps.2600590935

Cited by 12 publications

(5 citation statements)

References 3 publications

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“…These pseudosolutions with a high amiodarone content show complex sedimentation profiles during ultracentrifugation, suggesting the presence of micelles . NMR studies indicated a reversible disruption of micelles at 60 °C b).…”

Section: Introductionmentioning

confidence: 93%

“…4 NMR studies indicated a reversible disruption of micelles at 60 °C. 5 These clear pseudosolutions ceased to be transparent and showed a milky opalescence at room temperature, when diluted at concentrations close to the cmc, a process initiated without pH increase (Figure 1b). On the contrary, at higher concentrations, birefringent lamellar phases differentiated and a further isotropic state appeared.…”

Section: Introductionmentioning

confidence: 99%

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Liquid Crystals and Colloids in Water−Amiodarone Systems

et al. 1998

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Amiodarone, a molecule used in treatment of heart arrhythmias, presents several metastable states. Transparent sols (50 mg/mL) and gels (100 mg/mL) are obtained by heating amiodarone crystals in water to 70 °C and cooling to 20 °C. These preparations diluted in water remained transparent above 1.5 mg/mL, but further dilutions resulted in a milky cloud, which was studied by light scattering and photon correlation spectroscopy. A swollen smectic phase appeared at 200 mg/mL and another isotropic gel at 500 mg/mL. This behavior is similar to that of some classical lyotropic liquid crystals.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Liquid Crystals and Colloids in Water−Amiodarone Systems

et al. 1998

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“…These solutions show complex sedimentation profiles during centrifugation, suggesting the presence of micelles [8]. NMR studies indicated a reversible disruption of aggregates at 60°C [9]. This clear phase defined as a pseudo-solution [10] ceased to be transparent and showed a milky opalescence at room temperature, when diluted at concentrations close to the CMC.…”

Section: Introductionmentioning

confidence: 95%

Colloidal properties of amiodarone in water at low concentration

Benedini¹,

Messina²,

Manzo³

et al. 2010

Journal of Colloid and Interface Science

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“…Superfusate containing the same percentage of diluent alone was routinely used as a control, although exposure to 0.05vo1% diluent yield a trivial action potential shortening, by 1%-4% (not significant) in a preliminary experiment. The addition of amiodarone stock solution to the warmed and oxygenated Tyrode's solution led to cloudiness of the superfusate due to the formation of micelles [15], but did not produce any macroscopic precipitation. Superfusate containing 1.0gM isoproterenol was prepared directly by dissolving/-isoproterenol (Sigma, St Louis, Mo.)…”

Section: Drugsmentioning

confidence: 99%

“…Amiodarone exerts dose-and rate-dependent suppression on each current individually. However, amiodarone itself acts as do micelles [15], and hence the effective dose varies depending on the temperature and anion content. Moreover, the dose-effectiveness of amiodarone on each current differs among these currents.…”

Section: Effects On Apd9o and Erpmentioning

confidence: 99%

Acute effects of amiodarone on membrane properties, refractoriness, and conduction in guinea pig papillary muscles

et al. 1995

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Amiodarone has potent and complex antiarrhythmic effects associated with a rare incidence of proarrhythmia. For a comprehensive understanding of its antiarrhythmic mechanisms in the same preparations, amiodarone (50 microM) was employed as it would be in the clinical setting and applied to guinea pig papillary muscles impaled by microelectrodes, paced at different rates, and superfused with various concentrations of potassium ([K]e). Amiodarone exerted complex actions, as follows: (1) The maximum rate of rise (Vmax) of the fast action potential (i.e., [K]e = 5.4-9.0 mM) as well as that of the slow action potential (i.e., [K]e = 15.0 mM in the presence of 1.0 microM isoproterenol) was suppressed in a rate-dependent manner. (2) Amiodarone exhibited a rate- and [K]e-dependent increase in the ratio of effective refractory period vs action potential duration at 90% repolarization (ERP/APD90), disclosing post-repolarization refractoriness. (3) Amiodarone had no effect on passive cable factors, such as threshold current and tissue resistance, during propagation. These versatile electrophysiological effects of amiodarone may contribute to its unique antiarrhythmic effects, as well as the low incidence of proarrhythmia with this drug.

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Observations on the Micelle Formation of 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl Ketone Hydrochloride (SK&F 33 134-A) by NMR Spectroscopy

Cited by 12 publications

References 3 publications

Liquid Crystals and Colloids in Water−Amiodarone Systems

Liquid Crystals and Colloids in Water−Amiodarone Systems

Colloidal properties of amiodarone in water at low concentration

Acute effects of amiodarone on membrane properties, refractoriness, and conduction in guinea pig papillary muscles

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