Observed outcomes on the use of oxidized and regenerated cellulose polymer for breast conserving surgery - A case series

Abstract

BackgroundOxidized regenerated cellulose polymer (ORCP) may be used for reshaping and filling lack of volume in breast-conserving surgery (BCS). The study aimed to observe both the aesthetic and diagnostic outcomes in patients with different age, BMI, breast volume, and breast tissue composition over 36 months after BCS with ORCP.Patients and methods18 patients with early breast cancer and with proliferative benign lesions underwent BCS with ORCP that was layered in three-dimensional wafer, and placed into the Chassaignac space between the mammary gland and the fascia of pectoralis major with no fixation. After surgery, patients started a clinical and instrumental 36-month follow-up with mammography, ultrasonography, magnetic resonance imaging (MRI) and cytological examination with fine needle aspiration when seroma occurred.ResultsBelow the median age of 66 years old no complications were observed even in case both of overweight, and large breasts with low density. Over the median age seromas occurred with either small or large skin retraction, with the exception of 1 patient having quite dense breasts and low BMI, which had no complications. In elderly patients, 1 case with quite dense breasts and high BMI showed severe seroma and skin retraction, while 1 case with low BMI and less dense breasts highlighted milder complications.ConclusionDuring 36 months after BCS with ORCP, a significant correlation between positive diagnostic and aesthetic outcomes and low age, dense breasts, and low BMI of patient was observed. Despite of the few number of cases, either low BMI, or high breast density improved the aesthetic outcomes and reduced the entity of complications even in the elderly patients.

The Comparison of Breast Reconstruction Using Two Types of Acellular Dermal Matrix after Breast-Conserving Surgery

“…Hyperlipidemia and chemotherapy are both associated with an inflammatory response, which may be the cause of ADM side effects [ 15 , 16 ]. Oxidized regenerated cellulose polymer (ORCP), one of the biomaterials similar to ADM, has been used in breast-conserving surgery to make up the breast shape [ 17 , 18 ]. ORCP differs from the ADM in that it is absorbed into the surrounding tissues after surgery.…”

“…ORCP differs from the ADM in that it is absorbed into the surrounding tissues after surgery. Therefore, when ORCP is inserted, the lower the tissue density, the higher the risk of fat necrosis and the lower the effectiveness of mammoplasty [ 18 ]. On the other hand, the ADM is not absorbable material.…”

The efficacy of oxidized regenerated cellulose (SurgiGuard®) in breast cancer patients who undergo total mastectomy with node surgery: A prospective randomized study in 94 patients

“…ORC has a possible role as a reconstructive biomaterial and a few reports in the plastic surgery literature present the improvement of aesthetic outcomes in patients undergoing oncoplastic procedures for breast cancer. ORC integration and digestion processes are observed by diffuse fibrosis and homogeneous neovascularization within the construct [12,28,29]. ORC may be used to help manage exudate and promote granulation tissue development and moist wound healing [30].…”

Computational mechanobiology model evaluating healing of postoperative cavities following breast-conserving surgery

“…[ 14 ], [ 15 ], [ 67 ]- [ 69 ]. In summary, since patient-specific characteristics are intertwined and significantly affect post-lumpectomy healing and cosmetic outcomes, there is a need for a predictive tool to better understand the mechanistic interplay between these contributing factors.…”