Obsessive Compulsive Disorder with Bipolar Mood Disorder: A Rare Comorbidity in India

Annigeri, Bindu; Raman, Rajesh; Appaji, Rashmi

doi:10.4103/0253-7176.85403

Cited by 4 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, GAD is thought to belong to the mood disorders spectrum especially being related to MDD (Mennin et al 2008). Among patients with bipolar disorder (BD), comorbid anxiety disorders may occur in up to 75% of individuals (Hawke et al 2013) with a high prevalence of GAD, social (13.3%), and specific phobias (10.8%) and panic disorder (16.8%) (Hawke et al 2013;Nabavi et al 2015;Otto et al 2004;Annigeri et al 2011;Peng and Jiang 2015).…”

Section: Introductionmentioning

confidence: 99%

Generalized Anxiety Disorder (GAD) and Comorbid Major Depression with GAD Are Characterized by Enhanced Nitro-oxidative Stress, Increased Lipid Peroxidation, and Lowered Lipid-Associated Antioxidant Defenses

et al. 2018

View full text Add to dashboard Cite

Accumulating evidence shows that nitro-oxidative pathways play an important role in the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD) and maybe anxiety disorders. The current study aims to examine superoxide dismutase (SOD1), catalase, lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), advanced oxidation protein products (AOPP), malondialdehyde (MDA), glutathione (GSH), paraoxonase 1 (PON1), high-density lipoprotein cholesterol (HDL), and uric acid (UA) in participants with and without generalized anxiety disorder (GAD) co-occurring or not with BD, MDD, or tobacco use disorder. Z unit-weighted composite scores were computed as indices of nitro-oxidative stress driving lipid and protein oxidation. SOD1, LOOH, NOx, and uric acid were significantly higher and HDL and PON1 significantly lower in participants with GAD than in those without GAD. GAD was more adequately predicted by increased SOD + LOOH + NOx and lowered HDL + PON1 composite scores. Composite scores of nitro-oxidative stress coupled with aldehyde and AOPP production were significantly increased in participants with comorbid GAD + MDD as compared with all other study groups, namely MDD, GAD + BD, BD, GAD, and healthy controls. In conclusion, GAD is characterized by increased nitro-oxidative stress and lipid peroxidation and lowered lipid-associated antioxidant defenses, while increased uric acid levels in GAD may protect against aldehyde production and protein oxidation. This study suggests that increased nitro-oxidative stress and especially increased SOD1 activity, NO production, and lipid peroxidation as well as lowered HDL-cholesterol and PON1 activity could be novel drug targets for GAD especially when comorbid with MDD.

show abstract

Section: Introductionmentioning

confidence: 99%

Generalized Anxiety Disorder (GAD) and Comorbid Major Depression with GAD Are Characterized by Enhanced Nitro-oxidative Stress, Increased Lipid Peroxidation, and Lowered Lipid-Associated Antioxidant Defenses

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Until the 19 th century, it was thought that comorbidity of bipolar disorder (BD) and obsessive compulsive disorder (OCD) is rare and few studies had reported the comorbidity of bipolar disorder with obsessive compulsive disorder (BD-OCD) (1). Recent epidemiological studies, however, have shown that lifetime prevalence of OCD in bipolar patients ranges from 3.2% to 35% (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Comparison of socio-demographic and clinical features of bipolar patients with and without obsessive compulsive disorder

Hedayati¹,

Javadpour²,

Bazrafshan³

et al. 2011

JMOOD

View full text Add to dashboard Cite

ÖZET:Obsesif kompülsif bozukluğu olan ve olmayan iki uçlu bozukluk hastalarının klinik ve sosyodemograifk özelliklerinin karşılaştırılması Amaç: Epidemiyolojik çalışmalar iki uçlu bozukluğu olan hastalarda obsesif kompülsif bozukluğun hayat boyu yaygınlığının %3.2 ile %35 arasında olduğunu göster-mektedir. Bu arada iki uçlu bozukluğun obsesif kompülsif bozukluk ile birlikte olduğu (İUB-OKB) ve olmadığı (saf İUB) hastalarla yapılan ve hastaların demografik ve klinik özelliklerini değerlendiren birkaç çalışmanın yayınlanan sonuçları tartışmalıdır. Bu çalışmanın amacı iki uçlu bozukluk hastalarından OKB ekhastalığı olan ve olmayanların sosyodemografik ve klinik özelliklerini karşılaştırmaktır. Yöntem: DSM-IV Eksen I Bozuklukları için Yapılandırılmış Psikiyatrik Görüşme Formu (SCID-I) ile tanı konmuş 204 yatan hastanın katıldığı kesitsel, basit yapılı hastane kaynaklı bir çalışmadır. Demografik ve klinik değişkenler Yale-Brown obsesyon kompulsiyon ölçeği, Bech-Rafaelsen mania ölçeği ve Hamilton depresyon ölçeğinden elde edildi. Bulgular: İki uçlu bozukluğu (İUB) olan 204 hastadan saf İUB'si olan 123 (%60.3) ve İUB-OKB'si olanlar ise 81 (%39.7) idi. İUB-OKB ve saf İUB grupları arasında eğitim (p=0.036) ve medeni durumlarında (p=0.022) önemli farklılıklar vardı. Gruplar karşılaştırıldığında klinik özelliklerden: intihar düşüncesi, yatkınlığı ve girişimleri (p=0.000); başvuru sıklığı (p=0.044); madde kötüye kullanım öyküsü (p=0.001), ailede OKB öyküsü (p=0.000); ailede duygudurum bozukluğu öyküsü (p=0.036) önemli farklılıklar göstermekteydi. Sonuç: İUB ve OKB ekhastalığının belirgin demografik ve klinik özelliklerinin olması tanısal ve tedavi açısından farklı yaklaşımlara ihtiyacı olabilecek özel bir iki uçlu bozukluk tipi olabileceği izlenimini uyandırmaktadır. İlerideki çalışmalar bu alandaki bilgilerimizi artırmamıza yardımcı olabilir. There were significant differences between BD-OCD and pure BD group in terms of education (p=0.036) and marital status (p=0.022). Of clinical features, suicidal thoughts, tendencies, and attempts (p=0.000), frequency of admission (p=0.044), history of substance abuse (p=0.001), family history of OCD (p=0.000), and family history of mood disorder (p=0.036) were significantly different between the groups. Conclusions: Distinct demographic and clinical characteristics of bipolar patients with OCD comorbidity suggest a specific type of bipolar mood disorder which might need a different diagnostic and therapeutic management. Further longitudinal studies may assist in enhancing our knowledge in this field.

show abstract

“…OCD is known to worsen in depression and improve in hypomania/mania 2,4 . Mania in OCD can occur either as an independent comorbidity or as a result of an antidepressant-induced switch in a patient on anti-OCD drugs 9,10 . We describe and discuss some aspects of this psychiatric comorbidity, with emphasis on its diagnostics and management, based on a case report.…”

Section: Introductionmentioning

confidence: 99%

1692 – Obsessive-compulsive-bipolar disorder comorbidity: a case report

Ribeiro

et al. 2013

European Psychiatry

View full text Add to dashboard Cite

show abstract

Obsessive Compulsive Disorder with Bipolar Mood Disorder: A Rare Comorbidity in India

Cited by 4 publications

References 15 publications

Generalized Anxiety Disorder (GAD) and Comorbid Major Depression with GAD Are Characterized by Enhanced Nitro-oxidative Stress, Increased Lipid Peroxidation, and Lowered Lipid-Associated Antioxidant Defenses

Generalized Anxiety Disorder (GAD) and Comorbid Major Depression with GAD Are Characterized by Enhanced Nitro-oxidative Stress, Increased Lipid Peroxidation, and Lowered Lipid-Associated Antioxidant Defenses

Comparison of socio-demographic and clinical features of bipolar patients with and without obsessive compulsive disorder

1692 – Obsessive-compulsive-bipolar disorder comorbidity: a case report

Contact Info

Product

Resources

About