Obstructive – Nonobstructive hypertrophic cardiomyopathy: differences and predictors

Zebras Também Existem!

“…The authors indicated that the HCM group presents more significant structural and functional cardiac changes, resulting in more pronounced symptoms and the need for drug interventions. 7 These findings corroborate the pathophysiological mechanism implicated in the origin of both diseases, while in HCM mutations in cardiac sarcomere genes trigger hypertrophy, disarray, and fibrosis, in FD, the deposition of Gb3 in cardiomyocytes activate inflammatory and neurohormonal mechanisms involved in the formation of hypertrophy and tissue fibrosis, although indirectly and to a lesser extent. 8 The decrease in the glomerular filtration rate was more significant in FD since renal impairment occurs progressively and early; however, it is important to highlight that in this context of diagnosis differential, it is a finding that must be carefully considered.…”

“…However, early diagnosis and treatment are essential to prevent the progression of the disease by reducing cardiovascular event rates. [4][5][6] With the aim of investigating the clinical and exam differences between HCM and DF, the study of Akhan et al 7 retrospectively evaluated 60 patients with HCM and 40 with FD. In this population, with a similar average age, the authors showed, in general, that the characteristics of the two cardiac conditions share more similarities than differences, making diagnosis a challenge in clinical practice.…”