Obstructive response of human bladder to BPH vs. rabbit bladder response to partial outlet obstruction: A direct comparison

Levin, Robert M.; Haugaard, Niels; O’Connor, Laura; Buttyan, Ralph; Das, Anupam; Dixon, J. S.; Gosling, J. A.

doi:10.1002/1520-6777(2000)19:5<609::aid-nau7>3.0.co;2-h

Cited by 213 publications

(66 citation statements)

References 87 publications

(131 reference statements)

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“…Our study was able to confirm results obtained in experimental animals with artificial BOO; these studies showed a significant increase of detrusor contraction power and bladder weight during the initial and compensated stages during which bladder emptying remains complete [2]. Microscopic investigations of the bladder wall in these two stages revealed-besides fibroblast hyperplasia and deposition of collagen fibers-smooth muscle cell hypertrophy.…”

Section: Discussionsupporting

confidence: 88%

“…However, the basic principle of increasing BCI or W max with rising Schäfer grade remains unaffected by potential straining during voiding because straining is likely to appear with similar frequency in all BOO groups. Additionally, it remains to be determined whether our results are only valid for maximum detrusor contraction power or also true for detrusor contraction duration, another component of DU [2,17].…”

Section: Discussionmentioning

confidence: 94%

“…Microscopic investigations of the bladder wall in these two stages revealed-besides fibroblast hyperplasia and deposition of collagen fibers-smooth muscle cell hypertrophy. Animal studies suggest that bladder emptying in the presence of BOO persists due to increasing detrusor contraction power as a result of structural changes of the bladder wall [2,22]. Additionally, the results of our present study are in line with conclusions from previous studies showing a significant increase of bladder/detrusor wall thickness in symptomatic male patients with BOO [4,5]; therefore, increased detrusor contraction power in patients seems to be generated by increased mass of smooth muscle cells of the bladder wall (detrusor) as well.…”

Section: Discussionmentioning

confidence: 99%

“…In experimental animals with BOO, bladder wall (smooth muscle cell) hypertrophy and increase of detrusor contraction power develop quickly after partial ligature of the urethra resulting in complete bladder emptying in the initial and compensated stages despite the presence of BOO [2,3]. Bladder wall hypertrophy, diagnosed by ultrasound measurement of bladder or detrusor wall thickness, has been confirmed in adult men with BOO [4,5].…”

Section: Introductionmentioning

confidence: 90%

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Detrusor contraction power parameters (BCI and W max) rise with increasing bladder outlet obstruction grade in men with lower urinary tract symptoms: results from a urodynamic database analysis

2014

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In adult male LUTS patients, detrusor contraction power parameters-BCI and W max-continuously increase with rising BOO grade. According to our results, it is impossible to determine a single threshold value for detrusor contraction power to diagnose detrusor underactivity in a group of LUTS patients with different BOO grades. The study is limited to men with non-neurogenic LUTS. Future studies should evaluate exact threshold values for BCI and W max in BOO subgroups to adequately define detrusor underactivity and investigate men with other bladder conditions.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

See 2 more Smart Citations

Detrusor contraction power parameters (BCI and W max) rise with increasing bladder outlet obstruction grade in men with lower urinary tract symptoms: results from a urodynamic database analysis

2014

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“…Üretral rezistansı artıran MÇO mesane duvar gerilimini ve miksiyon basıncını artırmakta-dır. MÇO'yu kompanse etmek için mesane detrüsör düz kas hipertrofisi, artmış kollajen depozisyonu, vasküler değişiklikler ve nöroa-natomik yapısal ve iletimsel değişiklikler gibi seri patolojik cevaplar göstermektedir [10,11]. Bu yüzden bazı BPH hastalarında AÜSS'nin çıkım obstrüksiyonuyla direk ilişkiden ziyade MÇO'ya bağlı değişmiş mesane fonksiyonuna bağlı olduğu bilinmelidir.…”

Section: Bph Ve Klinik Kavramlarunclassified

Benign Prostat Hiperplazisinde Prostatik Arter Embolizasyonu

Eldem¹,

Fakultesi²,

Peynircioğlu³

2018

Trd Sem

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Spatiotemporal expression of smooth muscle markers in developing zebrafish gut

Georgijevic

Subramanian

Rollins

et al. 2007

Developmental Dynamics

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Smooth muscle is important for the contractility and elasticity of visceral organs. The zebrafish is an excellent model for understanding embryonic development, yet due to a lack of appropriate markers, visceral smooth muscle development remains poorly characterized. Here, we develop markers and trace the development of gut and swim bladder smooth muscle in embryonic and juvenile fish. The first smooth muscle marker we detect in the vicinity of the gut is the myoblast marker nonmuscle myosin heavy chain-b at 50 hours postfertilization (hpf), followed by the early smooth muscle markers SM22␣-b, and ␣-smooth muscle actin at 56 and 60 hpf, respectively. Markers of more differentiated smooth muscle, smoothelin-b and cpi-17, appear by 3 days postfertilization (dpf). Tropomyosin, a relatively late marker, is first expressed at 4 dpf. We find that smooth muscle marker expression in the swim bladder follows the same sequence of marker expression as the gut, but markers have a temporal delay reflecting the later formation of swim bladder smooth muscle. Developmental Dynamics 236:1623-1632, 2007.

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Obstructive response of human bladder to BPH vs. rabbit bladder response to partial outlet obstruction: A direct comparison

Cited by 213 publications

References 87 publications

Detrusor contraction power parameters (BCI and W max) rise with increasing bladder outlet obstruction grade in men with lower urinary tract symptoms: results from a urodynamic database analysis

Detrusor contraction power parameters (BCI and W max) rise with increasing bladder outlet obstruction grade in men with lower urinary tract symptoms: results from a urodynamic database analysis

Benign Prostat Hiperplazisinde Prostatik Arter Embolizasyonu

Spatiotemporal expression of smooth muscle markers in developing zebrafish gut

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