Obstructive Sleep Apnea and Cardiovascular Disease

Parish, James M.; Somers, Virend K.

doi:10.4065/79.8.1036

Cited by 456 publications

(301 citation statements)

References 130 publications

Supporting

Mentioning

264

Contrasting

Unclassified

Order By: Relevance

“…OSA is associated with coronary risk factors 26,27,28,29,30,31 and with known symptomatic coronary artery disease identified by angiography 32 . OSA was present in 9 of 10 patients with nocturnal angina pectoris 33 and in 37% of men and 30% of women with coronary artery disease 34 .…”

Section: Discussionmentioning

confidence: 99%

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

et al. 2012

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA), a risk factor for coronary artery disease, remains under diagnosed. We investigated if OSA identified by the Berlin Questionnaire (BQ) is associated with the risk of coronary artery disease. Cases were patients referred for elective coronariography. The cases were classified with significant coronary lesions (stenosis > 50% in an epicardial coronary) or without significant coronary lesions. Controls were selected from a population-based sample. Positive BQ results were identified in 135 (41.2%) of 328 cases, in contrast with 151 (34.4%) of 439 control subjects (p = 0.03). In a multinomial logistic analysis, the risk for OSA identified by the BQ was independently associated with coronary artery disease in cases with lesions of at least 50% (OR = 1.53; 95%CI: 1.02-2.30; p = 0.04). The risk from OSA identified by the BQ was higher in younger subjects (40-59 years) (OR = 1.76; 95%CI: 1.05-2.97; p = 0.03) and in women (OR = 3.56; 95%CI: 1.64-7.72; p = 0.001). In conclusion, OSA identified by the BQ greatly increases the risks of coronary artery disease in patients having significant coronary artery lesions indicated by anangiogram, particularly in younger individuals and in women.

show abstract

Section: Discussionmentioning

confidence: 99%

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

et al. 2012

View full text Add to dashboard Cite

show abstract

“…3 Previous studies have suggested that OSAS acts as an independent risk factor and leads to hypertension, heart disease, and stroke through the mechanisms described above. [4][5][6] OSAS can have a similar effect on the eye. According to some reports, the prevalence of primary open-angle glaucoma is increased in patients with OSAS.…”

Section: Introductionmentioning

confidence: 95%

Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS)

Chen

Wang

Zhang

et al. 2014

Eye

View full text Add to dashboard Cite

Objective To assess the macular retina and choroidal thickness change in patients with obstructive sleep apnea-hypopnea syndrome (OSAS) with no significant symptoms and pathological changes in the fundus using spectral domain-optical coherence tomography. Methods This prospective, observational case-control study consisted of 53 eyes of 53 patients with OSAS and 12 eyes of 12 age-matched controls. Macular and choroidal thicknesses were measured by optical coherence tomography. Results The foveal and nasal macular thicknesses were significantly different between four groups (P ¼ 0.001, P ¼ 0.016). The foveal thickness of the control group was significantly thinner than that of the severe group (P ¼ 0.000). The nasal macular thickness of the control group was significantly thinner than that of the severe group (P ¼ 0.008). A significant correlation was found between oxygen desaturation index (ODI) and macular center thickness (r ¼ 0.357, R 2 ¼ 0.127, P ¼ 0.004), with an ODI coefficient of 0.457 (P ¼ 0.004). Similarly, a significant correlation was found between ODI and nasal macular thickness (r ¼ 0.265, R 2 ¼ 0.070, P ¼ 0.033), with an ODI coefficient of 0.233 (P ¼ 0.033). The subfoveal choroidal thickness was significantly different among the groups (F ¼ 3.657, P ¼ 0.017). The subfoveal choroidal thickness of the severe group was significantly thinner than that of the control group, mild group, and moderate group (P ¼ 0.023, 0.006, and 0.036, respectively). The choroidal thickness 1 mm nasal to the fovea was significantly different between the groups after correcting for age and diopter (F ¼ 3.411, P ¼ 0.023). The choroidal thickness 1 mm nasal to the fovea was significantly thinner in the severe group compared with the control group and mild group (P ¼ 0.013 and 0.010, respectively). Choroidal thickness was significantly correlated with diopter (r ¼ 0.520, R 2 ¼ 0.270, Po0.001), with a coefficient of 0.327 (Po0.001), and with ODI (r ¼ 0.520, R 2 ¼ 0.165, P ¼ 0.001), with a coefficient of À 0.370 (P ¼ 0.001). Conclusions OSAS patients showed decreased foveal and nasal macular thickness, similar to the subfoveal and nasal choroidal thickness. These findings suggest that, because of intermittent hypoxia, OSAS might change the retinal and choroidal blood supply.

show abstract

“…The incidence of OSA is approximately 4 % in adult population (2). OSA is an important health problem that is associated with several diseases including hypertension (HT), obesity, diabetes mellitus (DM), and cardiovascular disease (CVD) (3). Several factors have been proposed for the relationship between OSA and cardiovascular risk factors.…”

Section: Introductionmentioning

confidence: 99%

The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea

Sünbül¹,

Sünbül²,

Kanar³

et al. 2015

BLL

View full text Add to dashboard Cite

BACKGROUND: Obstructive sleep apnea (OSA) is characterized by reductions in breathing amplitude during sleep caused by an obstructed or collapsed upper airway. The neutrophil to lymphocyte ratio (NLR) has been proposed as a novel biomarker for systemic infl ammatory response. The aim of the present study was to evaluate the relationship between NLR and OSA. METHODS: The study population consisted of 195 consecutive patients with clinical suspicion of OSA. Full night polysomnography was performed for all patients. Patients with an apnea hypopnea index (AHI) ≥ 5 were considered to have OSA. NLR was calculated as the ratio of neutrophil count to lymphocyte count. RESULTS: While 130 patients (91 male, mean age: 49.9±9.8 years) had OSA, 65 patients (42 male, mean age: 48.7 ± 10.2 years) had normal fi ndings according to AHI scores. Cardiovascular risk factors such as hypertension, hyperlipidemia, diabetes mellitus and smoking were more common in patients with OSA. Patients with OSA had signifi cantly higher NLR than controls (1.87±0.80 vs 1.49±0.48, p=0.005). AHI score was signifi cantly correlated with NLR (r=0.228, p=0.001). NLR and presence of hyperlipidemia were independent predictors of OSA (OR: 2.451, 2.850, p=0.001, 0.004, respectively). NLR of 1.62 or higher predicted OSA with a sensitivity of 56.2 % and specifi city of 63.1 %. CONCLUSIONS: NLR was higher and also correlated with AHI score in patients with OSA which has not been reported previously. NLR more than 1.62 was an independent predictor of OSA. A simple, cheap white blood cell count may also give an idea about the presence and severity of OSA (Tab. 3, Fig. 3, Ref. 30). Text in PDF www.elis.sk. KEY WORDS: infl ammation, cardiovascular risk, neutrophil to lymphocyte ratio, obstructive sleep apnea.

show abstract

Obstructive Sleep Apnea and Cardiovascular Disease

Cited by 456 publications

References 130 publications

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS)

The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea

Contact Info

Product

Resources

About