Obstructive sleep apnea, COPD, the overlap syndrome, and mortality: results from the 2005&amp;ndash;2008 National Health and Nutrition Examination Survey

Du, Wei; Liu, Jun; Zhou, Jing; Ye, Dan; Yu, Ouyang; Deng, Qingnan

doi:10.2147/copd.s148735

Cited by 65 publications

(38 citation statements)

References 36 publications

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“…As outcomes are concerned, early studies reported lower PaO 2 and higher PaCO 2 in overlap patients compared to OSA patients with a similar AHI, associated with higher pulmonary artery pressure at rest and during exercise [112]. More recent observational studies reported increased mortality in overlap patients compared to OSA patients [113–115], and a protective effect of CPAP treatment [113, 116, 117]. By contrast, a complex study in over 6,000 subjects from the general population recently reported that mortality was higher in patients with SDB defined as AHI≥5, but occurrence of SDB and SDB severity could mitigate the effects of decreasing FEV 1 on mortality [118].…”

Section: Common Comorbidities In Osa Patientsmentioning

confidence: 99%

Obstructive sleep apnea and comorbidities: a dangerous liaison

Bonsignore

Baiamonte

Mazzuca

et al. 2019

Multidiscip Respir Med

187

116

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Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged recently, and new conditions significantly associated with OSA are increasingly reported. A high comorbidity burden worsens prognosis, but some data suggest that CPAP might be protective especially in patients with comorbidities. Aim of this narrative review is to provide an update on recent studies, with special attention to cardiovascular and cerebrovascular comorbidities, the metabolic syndrome and type 2 diabetes, asthma, COPD and cancer. Better phenotypic characterization of OSA patients, including comorbidities, will help to provide better individualized care. The unsatisfactory adherence to CPAP in patients without daytime sleepiness should prompt clinicians to examine the overall risk profile of each patient in order to identify subjects at high risk for worse prognosis and provide the optimal treatment not only for OSA, but also for comorbidities.

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Section: Common Comorbidities In Osa Patientsmentioning

confidence: 99%

Obstructive sleep apnea and comorbidities: a dangerous liaison

Bonsignore

Baiamonte

Mazzuca

et al. 2019

Multidiscip Respir Med

187

116

View full text Add to dashboard Cite

show abstract

“…212,213 ). OSA is a common condition and increases mortality in COPD patients 214 . We therefore recommend polygraphy prior to dNIV initiation 214 .…”

Section: Domiciliary Non-invasive Ventilationmentioning

confidence: 99%

Chronic obstructive pulmonary disease - diagnosis and management of stable disease; a personalized approach to care, using the treatable traits concept based on clinical phenotypes. Position paper of the Czech Pneumological and Phthisiological Society

Zatloukal

Brat

Neumannová

et al. 2020

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Additionally, it was demonstrated that patients with the OS have increased sympathetic activity, which makes them more liable for cardiac complications [37]. Hence, the inflammatory and oxidative stress pathways together can be critical to the serious clinical consequences observed in COPD and OSA when they coexist in the same patient [38].…”

Section: Pathophysiologymentioning

confidence: 99%

The deleterious effects of chronic obstructive pulmonary disease and obstructive sleep apnea: pathophysiology and implications on treatment

Gharib

2020

Egypt J Bronchol

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Background: Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are both common in the adult population. The coexistence and association of both COPD and OSA have been described as the overlap syndrome. The scope of the present review is to address the magnitude, pathophysiology, clinical presentations, and the deleterious consequences of the coexistence of COPD and OSA in the same patient as well as the current management and treatment options of this association. Main body of abstract: Epidemiological studies showed a prevalence of the overlap syndrome of up to 1% of the adult population. However, various studies agreed that this association is due to the fact that both COPD and OSA are common rather than an interaction of pathophysiology between the two affections. Nevertheless, sleep may cause adverse effects on breathing and lung functions. While these effects can be neglected in otherwise healthy individuals, they can lead in contrast to disastrous clinical outcomes particularly in vulnerable patients with the overlap syndrome leading to increased risk of cardiovascular diseases, acute COPD exacerbations, increased rates of hospitalizations, and nocturnal deaths. Current guidelines recommend polysomnography (PSG) as the gold standard investigation to diagnose sleep disorders and overlap syndrome. Treatment may include pulmonary rehabilitation, supplemental oxygen therapy, and non-invasive ventilation. Currently, continuous positive airway pressure (CPAP) therapy is the treatment of choice for the overlap syndrome. CPAP effects include improved respiratory mechanics; sleep quality, exercise tolerance, and prolonged survival. Conclusion: Both COPD and OSA are common in the general population and present a significant risk of increased morbidity and mortality when they coexist in the same patient. Clinicians must carefully evaluate the clinical outcomes and the high risk of cardiovascular complications related to the overlap syndrome. Current data indicate that CPAP treatment leads to amelioration of the health-related quality of life and improve survival in patients with the overlap syndrome.

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Obstructive sleep apnea, COPD, the overlap syndrome, and mortality: results from the 2005–2008 National Health and Nutrition Examination Survey

Cited by 65 publications

References 36 publications

Obstructive sleep apnea and comorbidities: a dangerous liaison

Obstructive sleep apnea and comorbidities: a dangerous liaison

Chronic obstructive pulmonary disease - diagnosis and management of stable disease; a personalized approach to care, using the treatable traits concept based on clinical phenotypes. Position paper of the Czech Pneumological and Phthisiological Society

The deleterious effects of chronic obstructive pulmonary disease and obstructive sleep apnea: pathophysiology and implications on treatment

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