Obstructive sleep apnea in head and neck cancer survivors

Saesen, Kelly; Veen, Julie van der; Buyse, Bertien; Nuyts, Sandra

doi:10.1007/s00520-020-05428-7

Cited by 17 publications

(13 citation statements)

References 28 publications

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“…There is a strong increased incidence of OSA in patients with head and neck cancer – both on presentation 864 and after radiation therapy, 865 likely related to changes in craniofacial anatomy.…”

Section: Comorbidities Associated With Osamentioning

confidence: 99%

International Consensus Statement on Obstructive Sleep Apnea

Chang

Goldberg

Alt

et al. 2023

Int Forum Allergy Rhinol

118

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Background: Evaluation and interpretation of the literature on obstructive sleep apnea (OSA) allows for consolidation and determination of the key factors important for clinical management of the adult OSA patient. Toward this goal, an international collaborative of multidisciplinary experts in sleep apnea evaluation and treatment have produced the International Consensus statement on Obstructive Sleep Apnea (ICS:OSA). Methods: Using previously defined methodology, focal topics in OSA were assigned as literature review (LR), evidence-based review (EBR), or evidencebased review with recommendations (EBR-R) formats. Each topic incorporated the available and relevant evidence which was summarized and graded on study quality. Each topic and section underwent iterative review and the ICS:OSA was created and reviewed by all authors for consensus. Results: The ICS:OSA addresses OSA syndrome definitions, pathophysiology, epidemiology, risk factors for disease, screening methods, diagnostic testing types, multiple treatment modalities, and effects of OSA treatment on multiple OSA-associated comorbidities. Specific focus on outcomes with positive airway pressure (PAP) and surgical treatments were evaluated. Conclusion:This review of the literature consolidates the available knowledge and identifies the limitations of the current evidence on OSA. This effort aims to create a resource for OSA evidence-based practice and identify future research needs. Knowledge gaps and research opportunities include improving the metrics of OSA disease, determining the optimal OSA screening paradigms, developing strategies for PAP adherence and longitudinal care, enhancing selection of PAP alternatives and surgery, understanding health risk outcomes, and translating evidence into individualized approaches to therapy.

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Section: Comorbidities Associated With Osamentioning

confidence: 99%

International Consensus Statement on Obstructive Sleep Apnea

Chang

Goldberg

Alt

et al. 2023

Int Forum Allergy Rhinol

118

View full text Add to dashboard Cite

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“…Additionally, we did not identify interventions addressing hearing loss 45 and renal dysfunction associated with cisplatin‐induced kidney injury, 46 which are both important side effects of treatment with chemotherapy that impact long‐term physical health and function. Additionally, despite the prevalence of sleep‐related breathing disorders in patients with HNC after treatment, 47,48 we did not find studies targeting obstructive sleep apnea or other causes of sleep complaints.…”

Section: Discussionmentioning

confidence: 80%

Interventions for head and neck cancer survivors: Systematic review

et al. 2022

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Background Interventions for head/neck cancer (HNC) survivors may not address their cancer‐related and general health needs. Methods Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guided this systematic review of studies from 2000 to 2021 of interventions targeting cancer survivors treated with curative‐intent, using MEDLINE, Embase, Emcare, and PsycINFO. Interventions were categorized into domains of the Quality of Cancer Survivorship Care Framework to characterize the scope and quality of interventions. Results We identified 28 studies for inclusion: 13 randomized and 15 non‐randomized. Most targeted surveillance/management of physical effects (n = 24) including 13 that also targeted psychosocial effects. Four studies addressed prevention/surveillance for recurrence/new cancers, one addressed health promotion/disease prevention, and one addressed chronic medical conditions. Most studies (n = 27) had medium‐high risk of bias. Conclusions There are few high‐quality studies addressing HNC survivorship. Future rigorously designed studies should address broader areas of care, including chronic disease management and health promotion/disease prevention.

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“…It has been reported by the Wisconsin Sleep Cohort study that the prevalence of moderate to severe OSA among 30-70 years old adults seems to be 10% [ 1 ]. Increasing studies have confirmed OSA as one risk factor of hypertension, coronary artery disease, stroke [ 2 – 4 ], and various cancers, like lung, head, and neck cancers [ 5 , 6 ]. Of note, OSA is highly prevalent in patients with abdominal aortic aneurysm (AAA) [ 7 ], and severe OSA may promote the expansion of AAA [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic Intermittent Hypoxia Regulates CaMKII‐Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm

Zou

et al. 2021

Oxidative Medicine and Cellular Longevity

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Obstructive sleep apnea (OSA) is highly prevalent in patients with abdominal aortic aneurysm (AAA). However, the effects of OSA on AAA initiation in a murine model of sleep apnea have not been completely studied. In this paper, Apoe-/- C57BL/6 mice infused with angiotensin II (Ang II) were placed in chronic intermittent hypoxia (CIH) condition for inducing OSA-related AAA. CIH significantly promoted the incidence of AAA and inhibited the survival of mice. By performing ultrasonography and elastic Van Gieson staining, CIH was found to be effective in promoting aortic dilation and elastin degradation. Immunohistochemical and zymography results show that CIH upregulated the expression and activity of MMP2 and MMP9 and upregulated MCP1 expression while downregulating α-SMA expression. Also, CIH exposure promoted ROS generation, apoptosis, and mitochondria damage in vascular smooth muscle cells (VSMCs), which were measured by ROS assay, TUNEL staining, and transmission electron microscopy. The result of RNA sequencing of mouse aortas displayed that 232 mRNAs were differently expressed between Ang II and Ang II+CIH groups, and CaMKII-dependent p38/Jnk was confirmed as one downstream signaling of CIH. CaMKII-IN-1, an inhibitor of CaMKII, eliminated the effects of CIH on the loss of primary VSMCs. To conclude, a mouse model of OSA-related AAA, which contains the phenotypes of both AAA and OSA, was established in this study. We suggested CIH as a risk factor of AAA initiation through CaMKII-dependent MAPK signaling.

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Obstructive sleep apnea in head and neck cancer survivors

Cited by 17 publications

References 28 publications

International Consensus Statement on Obstructive Sleep Apnea

International Consensus Statement on Obstructive Sleep Apnea

Interventions for head and neck cancer survivors: Systematic review

Chronic Intermittent Hypoxia Regulates CaMKII‐Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm

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