Obtaining Eye Films Based on Chitosan

Abstract

This work presents data on the study of the possibility of using the natural polysaccharide chitosan and a synthetic polymer of polyvinyl alcohol as a matrix for creating a polymer form in the form of a film with prolonged drug release. Eye films based on chitosan, as well as on the basis of chitosan and polyvinyl alcohol, have been developed by obtaining a composite injection. The immobilization of antibiotics in polyvinyl alcohol films leads to a pro nounced prolongation of the antibiotic action, at the same time, it significantly increases the penetration of the drug into the tissues and eye fluids, providing the necessary therapeutic concentration for 1 day, which certainly becomes a significant advantage of antibiotic administration methods. To study the yield of drugs from polymer dosage forms, the method of UV spectroscopy was used. The influence of the concentration of drugs on the dynamics of their release from polymer films in «in vitro» conditions was studied. It was found that their chitosan / PVA film has a longer release of the drug, which is indicative of a prolongation effect. The results which were obtained indicate the possibility of using a dosage form based on biocompatible high molecular weight compounds to create therapeutic systems with a diffusion mechanism of drug release.