Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice

Kubo, Kin‐ya; Yamada, Yukiko; Iinuma, Mitsuo; Iwaku, Fumihiko; Tamura, Yasuo; Watanabe, Kazuko; Nakamura, Hiroyuki; Onozuka, Minoru

doi:10.1016/j.neulet.2006.12.020

Cited by 72 publications

(68 citation statements)

References 16 publications

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“…In SAMP8 mice, raising the bite by approximately 0.1 mm using dental materials (bite-raised condition) induces age-dependent deficits in spatial learning in the Morris water maze [46][47][48][49][50][51][52][53] . Especially in aged SAMP8 mice, the bite-raised condition decreases neuron number 48) and increases hypertrophy and hyperplasia of glial fibrillary acid protein-labeled astrocytes 52) in the hippocampal CA3 region, suggesting that the bite-raised condition accelerates the hippocampal aging process.…”

Section: Effects Of Occlusal Disharmony On Cognitive Functionmentioning

confidence: 99%

“…In rodents and monkeys, application of dental materials to the upper molars [46][47][48][49][50][51][52][53] , attaching acrylic caps to the incisors [54][55][56] , or inserting occlusal splints in the maxilla 57,58) to raise the bite increases urinary cortisol excretion rates and plasma corticosterone levels by inducing acute and chronic stress. In monkey, the increased urinary cortisol levels induced by occlusal splints return to basal values when the splints are removed 58) .…”

Section: Effects Of Occlusal Disharmony On Cognitive Functionmentioning

confidence: 99%

See 1 more Smart Citation

Masticatory function and cognitive function

Kubo

Ichihashi²,

Kurata³

et al. 2010

Okajimas Folia Anat. Jpn.

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Section: Effects Of Occlusal Disharmony On Cognitive Functionmentioning

confidence: 99%

Section: Effects Of Occlusal Disharmony On Cognitive Functionmentioning

confidence: 99%

Masticatory function and cognitive function

Kubo

Ichihashi²,

Kurata³

et al. 2010

Okajimas Folia Anat. Jpn.

Self Cite

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“…Bite-raised mice and age-matched mice were trained in the Morris water maze beginning 8 days after resin application to evaluate spatial cognitive ability [8][9][10][11] . This test is commonly used to examine spatial cognitive ability related to hippocampal function [12][13] .…”

Section: Effect Of the Bite-raised Condition On Spatial Cognitive Abimentioning

confidence: 99%

“…hippocampus, including reduced hippocampal-dependent spatial cognitive ability and the death of hippocampal neurons 14,15) . Because bite-raised mice have reduced spatial cognitive ability, we examined the relationship between the bite-raised condition and the number of hippocampal neurons 10) . After completion of the Morris water maze training, the hippocampus was removed from mice anesthetized with an overdose of pentobarbital, thinly sectioned, and stained by the Nissl method.…”

Section: Effects Of the Bite-raised Condition On Age-induced Hippocammentioning

confidence: 99%

“…In rats, the application of a bite-raising device increases catecholamine secretion in the central nervous system (including the hypothalamus), corticosterone (CO) concentrations in the blood, and glucocorticoids (GC) in the urine [5][6][7] . Bite-raised mice also have impaired spatial cognitive ability, a hippocampal-dependent function in association with morphologic changes in the hippocampus [8][9][10][11] . These findings suggest that bite-raising, as a chronic stressor, induces systemic stress responses via the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Malocclusion induces chronic stress

Iinuma¹,

Ichihashi²,

Hioki³

et al. 2008

Okajimas Folia Anat. Jpn.

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Summary:We examined the effect of occlusal disharmony in senescence-accelerated (SAMP8) mice on plasma corticosterone levels, spatial learning in the water maze, fos induction, hippocampal neuron number, expression of glucocorticoid receptors (GR) and glucocorticoid receptor messenger ribonucleic acid (GRmRNA) in hippocampus and inhibitor of glucocorticoid (metyrapone).Bite-raised aged mice had significantly greater plasma corticosterone levels than age-matched control mice as well as impaired spatial memory and decreased Fos induction and a number of neurons in hippocampus. GR and GRmRNA expressions were significantly decreased in aged bite-raised mice compared with age-matched control mice. Pretreatment with metyrapone inhibited not only the bite-raised induced increase in plasma corticosterone levels, but also the reduction in the number of hippocampal neurons and impaired spatial learning.These datas suggest that the bite-raised condition may enhance the aging process in hippocampus, thereby leading to impairment of spatial memory by stress.

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Nasal obstruction during adolescence induces memory/learning impairments associated with BDNF/TrkB signaling pathway hypofunction and high corticosterone levels

Ogawa

Okihara

Kokai

et al. 2018

J of Neuroscience Research

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The hippocampus is an important brain region involved in memory and learning. Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor B (TrkB), and phospho-p44/p42 mitogen-activated protein kinase (MAPK) are known to contribute to hippocampal memory/learning. The present study aimed to clarify the effects of nasal obstruction during the growth period on memory/learning in an animal model, using combined behavioral, biochemical, and histological approaches. Male BALB/C mice underwent unilateral nasal obstruction (UNO) by cauterization at 8 days of age and were subjected to Y-maze and passive avoidance tests at 15 weeks of age. The serum corticosterone levels were measured using an enzyme-linked immunosorbent assay, and brain tissues were subjected to hematoxylin-eosin staining and histological analysis or homogenization and Western blot analysis. Compared with control mice, UNO mice had lower blood oxygen saturation levels and exhibited apparent memory/learning impairments during behavioral testing. Additionally, the UNO group had higher hippocampal BDNF levels and serum corticosterone levels, lower hippocampal TrkB and phospho-p44/p42 MAPK levels, and reduced neuron numbers relative to controls. Our findings suggest that UNO during adolescence affects the hippocampus and causes memory/learning impairments.

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Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice

Cited by 72 publications

References 16 publications

Masticatory function and cognitive function

Masticatory function and cognitive function

Malocclusion induces chronic stress

Nasal obstruction during adolescence induces memory/learning impairments associated with BDNF/TrkB signaling pathway hypofunction and high corticosterone levels

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