Occult lymph node metastasis and risk of regional recurrence in papillary thyroid cancer after bilateral prophylactic central neck dissection: A multi-institutional study

Lee, Young Chan; Na, Se Young; Park, Gi Cheol; Han, Ju Hyun; Kim, Seung-Woo; Eun, Young Gyu

doi:10.1016/j.surg.2016.07.031

Cited by 71 publications

(66 citation statements)

References 29 publications

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“…However, the discussions still continue for occult lymph node metastasis in clinical or radiological N0 necks. In many studies, it has been indicated that lymph node dissection has reduced recurrence and has been a positive effect on survival (12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Possible prediction of patterns of cervical lymph node spread based on primary tumor location in papillary thyroid carcinomas

Sancaktar¹,

Saylam²,

Öcal³

et al. 2019

Turk J Med Sci

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Backround/aim: Papillary thyroid carcinomas (PTC) frequently metastasize to regional lymph nodes. Our purpose was to investigate the predictive role of tumor location for lymph node metastasis pattern in PTCs. Materials and methods:Medical records of 110 PTC patients were reviewed retrospectively. Tumor location was determined as upper, middle, and lower pole according to ultrasonography (USG) findings. The effects of age, sex, tumor size, and location on lymph node metastasis were investigated. Results:The series comprised 87% females (n = 96) and 13% males (n = 14). Forty-three patients had central neck metastasis (CNM) and 14 had lateral neck metastasis (LNM). Upper pole tumors (UPT) metastasized to the central neck (CN) at a lower rate (17.6%) than middle (40.0%) or lower (48.5%) poles overall (P = 0.104), while it was at a significantly lower rate (13.3%) in the PTC group (P < 0.05). UPTs (n = 17) metastasized to the lateral neck (LN) almost 2-fold more. It was observed that 3 of 4 UPTs spread directly to the LN without CNM. Conclusion:In our opinion, UPTs have propensity to demonstrate metastasis to LN rather than the CN in PTCs. Therefore, UPTs should be evaluated meticulously in terms of LNM. New studies could suggest that CN dissection is not performed for low-risk PTCs in UPTs.

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Section: Discussionmentioning

confidence: 99%

Possible prediction of patterns of cervical lymph node spread based on primary tumor location in papillary thyroid carcinomas

Sancaktar¹,

Saylam²,

Öcal³

et al. 2019

Turk J Med Sci

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“…Furthermore, paratracheal lymph node dissection is often ignored. 4,5 Therefore, the present study aims to observe the metastasis of prelaryngeal lymph nodes in papillary thyroid carcinoma, and explore its related factors and clinical value, in order to further improve the surgical method of thyroid cancer, and reduce postoperative recurrence and metastasis.…”

Section: Introductionmentioning

confidence: 99%

<p>Clinical Study on Prelaryngeal Lymph Node Metastasis in Papillary Thyroid Carcinoma</p>

Gong

et al. 2020

CMAR

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Objective: This study aims to investigate the risk factors of prelaryngeal lymph node metastasis in papillary thyroid carcinoma and its clinical application value. Methods: The clinical pathological features and metastatic risks were statistically analyzed by reviewing 254 patients with papillary thyroid carcinoma, who received their first operation and prelaryngeal lymph node dissection in our department. Results: The detection of prelaryngeal lymph nodes, tumor size and any paratracheal lymph node metastasis were correlated with the number of paratracheal lymph node metastasis (P<0.05), but these were not correlated with age, gender, multiple foci, tumor size, any paratracheal lymph node metastasis, metastatic location, or foci location (P>0.05). Conclusion: Paratracheal lymph node metastasis indicates a high possibility of prelaryngeal lymph node metastasis. Paratracheal lymph node dissection combined with prelaryngeal lymph node dissection should be simultaneously considered in operations for thyroid papilla carcinoma.

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“…5 Cervical LNM rate is approximately 30~80%, while, lateral LNM rate is up to 64.2%. 6,7 Central lymph node metastasis (CLNM) has been proved to be an independent risk factor for local recurrence [8][9][10] and decreased survival rate. [11][12][13] At present, surgery is the main treatment for cervical LNM.…”

Section: Introductionmentioning

confidence: 99%

<p>Preoperative Sonographic and Clinicopathological Predictors for Solitary Lateral Neck Node Metastasis in Papillary Thyroid Carcinoma: A Retrospective Study</p>

Yang

Chen

et al. 2020

CMAR

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Background: Cervical lymph node metastasis (LNM) is an independent risk factor for poor prognosis of papillary thyroid carcinoma (PTC), but the scope of PTC lateral neck dissection (LND) is controversial. Solitary lateral lymph node metastasis (SLNM) is a special type of PTC with lateral LNM. Currently, study on the preoperative clinical characteristics of SLNM has been seldomly reported. This study evaluated the preoperative characteristics for predicting the SLNM of PTC. Methods: We included 391 patients diagnosed with PTC between May 2011 and July 2017. Among those patients, 44 had SLNM and 347 had multiple lateral neck node metastasis (MLNM). The clinicopathologic characteristics and other central lymph node metastasis risk factors were retrospectively analyzed. Results: Univariate analysis revealed that age and tumor size (≤1 cm) were significantly correlated with SLNM. In ROC curve analysis, the optimal cutoff age of preoperative predictors for the prediction of SLNM was 46.5 years (AUC=0.623, 0.536-0.710). Besides, the frequency and mean number of CLNM was significantly less in the SLNM than MLNM group. The oval and round tumor shape and well-defined margin of the tumor were more common in the SLNM group (p =0.001; p=0.024, respectively). In addition, multivariate analysis revealed that age ≥47, capsular invasion, no extrathyroidal extension, with central lymph node metastases and irregular shape were independent SLNM predictors of PTCs (odds ratio 2.386, 0.173, 0.284, 0.239, 0.188; 95%

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Occult lymph node metastasis and risk of regional recurrence in papillary thyroid cancer after bilateral prophylactic central neck dissection: A multi-institutional study

Cited by 71 publications

References 29 publications

Possible prediction of patterns of cervical lymph node spread based on primary tumor location in papillary thyroid carcinomas

Possible prediction of patterns of cervical lymph node spread based on primary tumor location in papillary thyroid carcinomas

<p>Clinical Study on Prelaryngeal Lymph Node Metastasis in Papillary Thyroid Carcinoma</p>

<p>Preoperative Sonographic and Clinicopathological Predictors for Solitary Lateral Neck Node Metastasis in Papillary Thyroid Carcinoma: A Retrospective Study</p>

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