Occult supraclavicular lymph node metastasis identified by FDG-PET in patients with carcinoma of the uterine cervix

Tran, Binh N.; Grigsby, Perry W.; Dehdashti, Farrokh; Herzog, Thomas J.; Siegel, Barry A.

doi:10.1016/s0090-8258(03)00402-5

Cited by 92 publications

(47 citation statements)

References 10 publications

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“…Previous work at our institution has shown that patients with FDG-PET evidence of paraaortic lymph node involvement have a poor prognosis, with only 18% 2-year progression-free survival, 9 and there were no survivors who presented with supraclavicular lymph node metastases. 16 FDG-PET evaluation of lymph nodes is superior to endometrial sampling alone, as some patients with evidence of pelvic lymph node involvement did not have endometrial extension.…”

Section: Discussionmentioning

confidence: 99%

FDG‐PET in carcinoma of the uterine cervix with endometrial extension

Hope

Saha

Grigsby

2005

Cancer

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BACKGROUNDThe authors wished to determine whether pretreatment pathologic evidence of endometrial invasion correlated with fluorine‐18 fluorodeoxyglucose positron emission tomography (FDG‐PET) findings and outcomes in patients with carcinoma of the uterine cervix.METHODSPretreatment whole body FDG‐PET was performed in 58 patients with cervical carcinoma who also underwent pathologic evaluation of the endometrium by biopsy or dilation and curettage. FDG‐PET lymph node status, disease free survival, and overall survival were evaluated.RESULTSThirty seven (64%) patients had pathologic evidence of endometrial invasion. Pelvic lymph node metastases were three times more frequent in patients with evidence of endometrial invasion compared with those without endometrial invasion (70% vs. 23%, P < 0.001). Patients with endometrial invasion also had a significantly increased risk of paraaortic and supraclavicular lymph node metastases at presentation (30% vs. 0% P = 0.006). Endometrial invasion was associated with a decreased 2‐year disease‐free survival (78% vs. 58%, P = 0.046) and overall survival (92% vs. 65%, P =0.047).CONCLUSIONSEndometrial extension in cervical cancer correlated strongly with risk of FDG‐PET detected lymph node metastases in this study's population and was associated with a poor prognosis. Cancer 2006. © 2005 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

FDG‐PET in carcinoma of the uterine cervix with endometrial extension

Hope

Saha

Grigsby

2005

Cancer

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“…All seven cases of SCN metastases cited above in Tran et al 7) passed away, from distant metastasis after CCRT. In addition, as one might expect, among the cases in which metastases reached the SCN in Kim JK et al 10) , 15 of the 25 cases (60%) that received CCRT were distant recurrences.…”

Section: Discussionmentioning

confidence: 86%

“…In the 2003 report by Tran et al 7) , the median survival of 7 cases treated with CCRT that included CDDP was 8 months. The ratio of SCN cases receiving irradiation was only 2 out of 7, and the dose was 45Gy.…”

Section: Discussionmentioning

confidence: 98%

A Patient with Stage IVB Cervical Cancer with Para-aortic Lymph Node (PAN) and Supraclavicular Lymph Node (SCN) Metastases Who Reached Long-term Survival with Chemoradiotherapy

Gomi

Shinozaki

Okada

et al. 2015

J St. Marianna Univ

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We report a case of a patient who demonstrated long-term survival following completion of concurrent chemoradiotherapy (CCRT) for stage IVB advanced uterine cervical cancer. When the patient was referred to us, her radiological findings showed para-aortic and supraclavicular lymph node (SCN) metastases. The CCRT for primary lesions and para-aortic lymph node (PAN) were performed, followed by radiotherapy for SCN, resulting in successful control of the lesions. After five and a half years of strict follow-up, recurrent PAN was observed with PET-CT. Systemic chemotherapy was re-stored and controlled recurrent PAN without signs of serious adverse events. The patient has showed no recurrent signs with any related symptoms for the past 8 years since the initial treatment. As seen in this case, favorable prognosis can be achieved even for stage IVB advanced uterine cervical cancer patients, when the distant metastases are located in lymph nodes where CCRT could fully cover.

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“…The utility of integrated PET/CT imaging is now well-established for the staging evaluation of patients with locally advanced cervical cancer, providing better sensitivity and specificity than either MRI or CT alone. 5,14 As utilization of PET/CT imaging in cervical cancer has increased, PALN metastases have been detected with greater frequency. Traditionally, para-aortic nodal volumes have been irradiated either with an extended field that includes both the para-aortic nodes and the pelvis or with two sets of separate fields.…”

Section: Discussionmentioning

confidence: 99%