Occupational Acroosteolysis

Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study

“…There exists a plausible biological basis for such an association [80]. Examples include the association of prolonged silica-dust exposure with scleroderma [81], the occurrence of Raynaud's phenomenon, sclerodermatous skin changes, and acroosteolysis among vinyl chloride workers [82,83]. …”

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants, Volume 1

“…Unfortunately, the exposure concentrations at which these effects were seen in workers are not known. Because Raynaud's disease was usually detected before acroosteolysis in vinyl-chloride workers, vascular lesion is believed to precede the bone changes (Dodson and Dinman, 1971). Viola (1970) reported that an exposure of rats at 30,000 ppm for 4 h/d, 5 d/w for 1 y resulted in pathology in the paws, such as metaplasia of metatarsal bones, chondroid metaplasia, epidermal edema, epidermal hyperkeratosis, and degeneration of basal cells.…”