Occupational airborne exposure, specific sensitization and the atopic status: evidence of a complex interrelationship

Baur, Xaver; Barbinova, Liubov

doi:10.1186/1745-6673-8-2

Cited by 3 publications

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disease is characterized by an irreversible and progressive development of airflow limitation featuring cough, mucus hypersecretion, inflammatory changes and remodeling of the airway wall [ 2 ]. Next to bronchial asthma [ 3 , 4 ], asbestosis [ 5 ], or tuberculosis [ 6 , 7 ], COPD also plays a major role in the field of occupational and environmental respiratory diseases [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease

Springer

Scholz

Peiser

et al. 2013

J Occup Med Toxicol

View full text Add to dashboard Cite

BackgroundTobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD). Suppressor of cytokine signaling (SOCS) family members are involved in the pathogenesis of many inflammatory diseases and SOCS-3 has been shown to play an important role in the regulation, onset and maintenance of airway allergic inflammation indicating that SOCS-3 displays a potential therapeutic target for anti-inflammatory respiratory drugs development. Since chronic obstructive pulmonary disease (COPD) is also characterized by inflammatory changes and airflow limitation, the present study assessed the transcriptional expression of SOCS-3 in COPD.MethodsReal-time PCR was performed to assess quantitative changes in bronchial biopsies of COPD patients in comparison to unaffected controls.ResultsSOCS-3 was significantly down-regulated in COPD at the transcriptional level while SOCS-4 and SOCS-5 displayed no change.ConclusionsIt can be concluded that the presently observed inhibition of SOCS-3 mRNA expression may be related to the dysbalance of cytokine signaling observed in COPD.

show abstract

Section: Introductionmentioning

confidence: 99%

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease

Springer

Scholz

Peiser

et al. 2013

J Occup Med Toxicol

View full text Add to dashboard Cite

show abstract

Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway

Kimber

Poole

Basketter

2018

Toxicology Research

View full text Add to dashboard Cite

Sensitisation of the respiratory tract to chemicals resulting in respiratory allergy and allergic asthma is an important occupational health problem, and presents toxicologists with no shortage of challenges. A major issue is that there are no validated or, even widely recognised, methods available for the identification and characterisation of chemical respiratory allergens, or for distinguishing respiratory allergens from contact allergens. The first objective here has been review what is known (and what is not known) of the mechanisms through which chemicals induce sensitisation of the respiratory tract, and to use this information to construct a hybrid Adverse Outcome Pathway (AOP) that combines consideration of both skin and respiratory sensitisation. The intention then has been to use the construction of this hybrid AOP to identify areas of commonality/confluence, and areas of departure/divergence, between skin sensitisation and sensitisation of the respiratory tract. The hybrid AOP not only provides a mechanistic understanding of how the processes of skin and respiratory sensitisation differ, buy also a means of identifying areas of uncertainty about chemical respiratory allergy that benefit from a further investment in research.

show abstract

Expression of VPAC1 in a murine model of allergic asthma

Lauenstein

Quarcoo

Welte

et al. 2013

J Occup Med Toxicol

View full text Add to dashboard Cite

Vasoactive intestinal polypeptide (VIP) is a putative neurotransmitter of the inhibitory non-adrenergic non-cholinergic nervous system and influences the mammalian airway function in various ways. Hence known for bronchodilatory, immunomodulatory and mucus secretion modulating effects by interacting with the VIP receptors VPAC1 and VPAC2, it is discussed to be a promising target for pharmaceutical intervention in common diseases such as COPD and bronchial asthma. Here we examined the expression and transcriptional regulation of VPAC1 in the lungs of allergic mice using an ovalbumin (OVA) -induced model of allergic asthma. Mice were sensitized to OVA and challenged with an OVA aerosol. In parallel a control group was sham sensitized with saline. VPAC1 expression was examined using RT-PCR and real time-PCR studies were performed to quantify gene transcription. VPAC1 mRNA expression was detected in all samples of OVA-sensitized and challenged animals and control tissues. Further realtime analysis did not show significant differences at the transcriptional level.Although the present studies did not indicate a major transcriptional regulation of VPAC1 in states of allergic airway inflammation, immunomodulatory effects of VPAC1 might still be present due to regulations at the translational level.

show abstract

Occupational airborne exposure, specific sensitization and the atopic status: evidence of a complex interrelationship

Cited by 3 publications

References 53 publications

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease

Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway

Expression of VPAC1 in a murine model of allergic asthma

Contact Info

Product

Resources

About